P. Ravichandiran

Synthesis and spectroscopic characterization of fluorescent 4-aminoantipyrine analogues: Molecular docking and in vitro cytotoxicity studies.

Two substituted aromatic carbonyl compounds (compounds 1 and 2) of 4-aminoantipyrine were synthesized by condensation of fluorine substituted benzoyl chlorides and 4-aminoantipyrine. The structures of synthesized derivatives were established on the basis of UV-Vis, IR, and Mass, (1)H, (13)C NMR and Fluorescence spectroscopy. Both compounds showed significant fluorescence emission and two broad emission bands were observed in the region at 340 nm and 450 nm on excitation at 280 nm. Theoretically to prove that the molecule has anticancer activity against cervical cancer cells, the compounds were analyzed for molecular docking interactions with HPV16-E7 target protein by Glide protocol. Furthermore, 4-aminoantipyrine derivatives were evaluated for their in vitro cytotoxic activity against human cervical cancer cells (SiHa) by MTT assay. Compound 1 showed two fold higher activity (IC50=0.912 μM) over compound 2, and its activity was similar to that of Pazopanib, suggesting that although the two compounds were chemically very similar the difference in substituent on the phenyl moiety caused changes in properties.

Synthesis of heterocyclic naphthoquinone derivatives as potent organic fluorescent switching molecules

Abstract Quinone is well known molecules for not only in the biological applications but which includes electrochemical and fluorescent applications too. In this paper we attempted to synthesize a series of 2-(4-amino-benzosulfonyl)-5H-benzo[b]carbazole-6,11-dione derivatives and these set of compounds were studied for their fluorescent switching properties. The title compounds were synthesized via Michael-like addition and followed by intramolecular C–C coupling. These compounds were studied for their fluorescent switching properties by using UV–vis, photoluminescence and cyclic voltagram techniques. Among all the molecules studied for their fluorescent switching properties the compounds 4a and 6a exhibited good fluorescent switching properties due to the presence of poor and strong electron withdrawing functional groups in the fourth position at the fluorophoric unit. All the synthesized compounds exhibited good fluorescent switching properties which were studied and confirmed by UV–vis, photoluminescence (PL) and cyclic voltagram (CV) techniques.

Synthesis, molecular docking and antibacterial evaluation of 2-(4-(4-aminophenylsulfonyl)phenylamino)-3-(thiophen-2-ylthio)naphthalene-1,4-dione derivatives

AbstractA new series of 2-(4-(4-aminophenylsulfonyl) phenylamino)-3-(thiophen-2-ylthio)naphthalene-1,4-dione derivatives (3a-3n) were synthesized and characterized by spectral techniques. To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed by the GLIDE program and compound N-(4-(4-(1,4-dioxo-3-(thiophen-2-ylthio)-1,4-dihydronaphthalen-2-ylamino)phenylsulfonyl)phenyl)-3-methylbenzamide (3b) exhibited good glide and E model scores of −5.89 and −94.90, respectively. Moreover among all the molecules studied including the standards used, namely Sparfloxacin (4.8 μg/mL) and Norfloxacin (no inhibition observed) for their antibacterial property, compound N-(4-(4-(1,4-dioxo-3-(thiophen-2-ylthio)-1,4-dihydronaphthalen-2-ylamino)phenylsulfonyl)phenyl)-4-nitrobenzamide (3e) exhibited the lowest minimum inhibitory concentration (MIC) value of 1.3 μg/mL against Proteus vulgaris.

Manganite nanorods supported palladium – a facile electrocatalyst for direct glycerol fuel cells

Manganite (MnOOH) nanorods were synthesised by a hydrothermal method and then used as a supportive material for Palladium towards glycerol electrooxidation in alkaline medium. The smaller quantities (5 and 15 weight %) of palladium are coated on the manganite nanorods by in situ reduction method. The electrooxidation of glycerol at Pd/Manganite electrode exhibits peak current vertexes at – 0.2 V, which is lower than Pd/C. By varying the alkali (KOH) and glycerol concentrations the electrocatalytic behaviour has been changed considerably and was discussed. The present study reveals that the manganite nanorods act as active support material for Pd. The support material will help to oxidise the intermediates formed during electrooxidation of fuel. The possibilities for the removal of poisonous intermediates were also discussed. The effect of support material on the electrooxidation reaction was explained by proper mechanism.