P. Saez
Stanford University
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Publication
Featured researches published by P. Saez.
Journal of Applied Physics | 1993
M. Woods; J. Frisch; A. Kulikov; P. Saez; D. Schultz; J. J. Turner; Klaus H. Witte; M. Zolotorev
The Stanford Linear Accelerator Center is currently operating with a photocathode electron gun (PEG) to produce polarized electrons for its experimental program. Bunch intensities of up to 1011 electrons within 2 ns (8 A) are required from the electron gun. Operation of PEG has demonstrated a charge limit phenomenon, whereby the charge that can be extracted from the gun with an intense laser beam saturates at significantly less than 1011 electrons (the expected space‐charge‐limited charge) when the photocathode quantum efficiency is low. Studies of this charge limit phenomenon observed with a GaAs photocathode are reported.
Biomechanics and Modeling in Mechanobiology | 2012
P. Saez; V. Alastrué; E. Peña; M. Doblaré; M.A. Martínez
An anisotropic damage model for soft fibered tissue is presented in this paper, using a multi-scale scheme and focusing on the directionally dependent behavior of these materials. For this purpose, a micro-structural or, more precisely, a microsphere-based approach is used to model the contribution of the fibers. The link between micro-structural contribution and macroscopic response is achieved by means of computational homogenization, involving numerical integration over the surface of the unit sphere. In order to deal with the distribution of the fibrils within the fiber, a von Mises probability function is incorporated, and the mechanical (phenomenological) behavior of the fibrils is defined by an exponential-type model. We will restrict ourselves to affine deformations of the network, neglecting any cross-link between fibrils and sliding between fibers and the surrounding ground matrix. Damage in the fiber bundles is introduced through a thermodynamic formulation, which is directly included in the hyperelastic model. When the fibers are stretched far from their natural state, they become damaged. The damage increases gradually due to the progressive failure of the fibrils that make up such a structure. This model has been implemented in a finite element code, and different boundary value problems are solved and discussed herein in order to test the model features. Finally, a clinical application with the material behavior obtained from actual experimental data is also presented.
Journal of Mathematical Biology | 2013
P. Saez; E. Peña; M.A. Martínez; Ellen Kuhl
We present a theoretical and computational model for collagen turnover in soft biological tissues. Driven by alterations in the mechanical environment, collagen fiber bundles may undergo important chronic changes, characterized primarily by alterations in collagen synthesis and degradation rates. In particular, hypertension triggers an increase in tropocollagen synthesis and a decrease in collagen degradation, which lead to the well-documented overall increase in collagen content. These changes are the result of a cascade of events, initiated mainly by the endothelial and smooth muscle cells. Here, we represent these events collectively in terms of two internal variables, the concentration of growth factor TGF-
Japanese Journal of Applied Physics | 1995
Y. Kurihara; T. Omori; Yasunori Takeuchi; M. Yoshioka; Tsutomu Nakanishi; Syooji Okumi; Mmasabumi Tawada; Kazuaki Togawa; M. Tsubata; Toshio Baba; Masashi Mizuta; Raymond K. Alley; H. Aoyagi; Josef C. Frisch; Gregory A. Mulhollan; P. Saez; D. Schultz; H. Tang; Klaus H. Witte
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment | 1994
D. Schultz; R. Alley; H. Aoyagi; J. Frisch; C.L. Garden; E.W. Hoyt; R.E. Kirby; L. Klaisner; A. Kulikov; G.A. Mulhollan; C.Y. Prescott; P. Saez; H. Tang; J. J. Turner; M. Woods; D. Yeremian; M. Zolotorev
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IEEE Transactions on Biomedical Engineering | 2011
P. Saez; E. Peña; M. Doblaré; M.A. Martínez
international conference on particle accelerators | 1993
H. Tang; R. Alley; H. Aoyagi; J. Frisch; C.L. Garden; E.W. Hoyt; R.E. Kirby; L. Klaisner; A. Kulikov; C.Y. Prescott; P. Saez; D. Schultz; James Turner; M. Woods; M. Zolotorev
and tissue inhibitors of metalloproteinases TIMP. The upregulation of TGF-
ieee particle accelerator conference | 1995
P. Saez; R. Alley; J. Frisch; R.E. Kirby; R. Mair; T. Maruyama; R. H. Miller; Gregory A. Mulhollan; G. Prescott; H. Tang; Klaus H. Witte
Archive | 2010
P. Saez; V. Alastrué; E. Peña; M.A. Martínez; M. Doblaré
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SPIE's 1993 International Symposium on Optics, Imaging, and Instrumentation | 1993
P. Saez; Ray K. Alley; H. Aoyagi; Josef Frisch; C. Garden; Earl Hoyt; Bob Kirby; L. Klaisner; A. Kulikov; C. Prescott; D. Schultz; H. Tang; James Turner; Klaus H. Witte; Michael Woods; M. Zolotorev