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Dive into the research topics where P. Surendra Reddy is active.

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Featured researches published by P. Surendra Reddy.


Journal of Medicinal Chemistry | 2011

Design and Synthesis of Resveratrol-Based Nitrovinylstilbenes as Antimitotic Agents

M. Amarnath Reddy; Nishant Jain; Deepthi Yada; Chandan Kishore; Vangala Janakiram Reddy; P. Surendra Reddy; Anthony Addlagatta; Shasi V. Kalivendi; B. Sreedhar

A new series of resveratrol analogues was designed, synthesized, and demonstrated to be tubulin polymerization inhibitors. Most of these compounds exhibited antiproliferative activity and inhibited in vitro tubulin polymerization effectively at concentrations of 4.4-68.1 and 17-62 μM, respectively. Flow cytometry studies showed that compounds 7c, 7e, and 7g arrested cells in the G2/M phase of the cell cycle. Immunocytochemistry revealed loss of intact microtubule structure in cells treated with 7c and 7e. Docking of compounds 7c and 7e with tubulin suggested that the A-ring of the compounds occupies the colchicine binding site of tubulin, which coordinates with Cys241, Leu242, Ala250, Val318, Val328, and I378, and that the nitrovinyl side chain forms two hydrogen bonds with the main loop of the β-chain at Asn249 and Ala250.


Synthetic Communications | 2007

Sonochemical Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles in Aqueous Medium

B. Sreedhar; P. Surendra Reddy

Abstract An ultrasound‐accelerated fast and efficient three‐component reaction for the regioselective synthesis of l,4‐disubstituted 1,2,3‐triazoles using different alkyl and allyl halides, terminal alkynes, and sodium azide in water at room temperature has been developed using CuI as catalyst. Ultrasonication dramatically decreases the reaction times.


Synthetic Communications | 2007

Rapid and Catalyst‐Free α‐Halogenation of Ketones using N‐Halosuccinamides in DMSO

B. Sreedhar; P. Surendra Reddy; M. Madhavi

Abstract α‐Halogenation of various carbonyl compounds such as β‐keto‐esters, cyclic ketones, and lactams with N‐halosuccinamides (NBS, NCS, NIS) in the presence of DMSO proceeded very smoothly to give the corresponding α‐monohalogenated products in good to excellent yields with high selectivity under catalyst‐free conditions.


Synthetic Communications | 2010

Stereoselective Cross-Coupling of Baylis–Hillman Acetates with Diphenyl Disulfides and Diselenides Using Palladium Acetate

P. Surendra Reddy; M. Amarnath Reddy; B. Sreedhar; M. V. Basaveswara Rao

An efficient method is described for the stereoselective synthesis of diorganyl chalcogenides from a variety of Baylis–Hillman acetates and diaryl chalcogens using palladium catalyst. This reaction is a convenient new method to produce unsymmetrical sulfides and selenides in good yields.


Journal of Molecular Catalysis A-chemical | 2006

Cellulose supported palladium(0) catalyst for Heck and Sonogashira coupling reactions

K. Rajender Reddy; Nadakudity S. Kumar; P. Surendra Reddy; B. Sreedhar; M. Lakshmi Kantam


Tetrahedron Letters | 2005

Ultrasound-assisted rapid and efficient synthesis of propargylamines

B. Sreedhar; P. Surendra Reddy; B. Veda Prakash; A. Ravindra


Tetrahedron Letters | 2006

Cu(I)-catalyzed one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via nucleophilic displacement and 1,3-dipolar cycloaddition

B. Sreedhar; P. Surendra Reddy; N. Sailendra Kumar


Tetrahedron Letters | 2007

An efficient synthesis of propargylamines using a silica gel anchored copper chloride catalyst in an aqueous medium

B. Sreedhar; P. Surendra Reddy; C.S. Vamsi Krishna; P. Vijaya Babu


Tetrahedron Letters | 2007

AgOTf catalyzed direct amination of benzyl alcohols with sulfonamides

B. Sreedhar; P. Surendra Reddy; M. Amarnath Reddy; B. Neelima; R. Arundhathi


Advanced Synthesis & Catalysis | 2010

Iron(III) Chloride-Catalyzed Direct Sulfonylation of Alcohols with Sodium Arenesulfinates

M. Amarnath Reddy; P. Surendra Reddy; B. Sreedhar

Collaboration


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B. Sreedhar

Indian Institute of Chemical Technology

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M. Amarnath Reddy

Indian Institute of Chemical Technology

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A. Ravindra

Indian Institute of Chemical Technology

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Anthony Addlagatta

Indian Institute of Chemical Technology

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B. Neelima

Indian Institute of Chemical Technology

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B. Veda Prakash

Indian Institute of Chemical Technology

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C.S. Vamsi Krishna

Indian Institute of Chemical Technology

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Divya Yada

Council of Scientific and Industrial Research

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K. Rajender Reddy

Indian Institute of Chemical Technology

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M. Lakshmi Kantam

Indian Institute of Chemical Technology

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