P. Surendra Reddy
Indian Institute of Chemical Technology
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Publication
Featured researches published by P. Surendra Reddy.
Journal of Medicinal Chemistry | 2011
M. Amarnath Reddy; Nishant Jain; Deepthi Yada; Chandan Kishore; Vangala Janakiram Reddy; P. Surendra Reddy; Anthony Addlagatta; Shasi V. Kalivendi; B. Sreedhar
A new series of resveratrol analogues was designed, synthesized, and demonstrated to be tubulin polymerization inhibitors. Most of these compounds exhibited antiproliferative activity and inhibited in vitro tubulin polymerization effectively at concentrations of 4.4-68.1 and 17-62 μM, respectively. Flow cytometry studies showed that compounds 7c, 7e, and 7g arrested cells in the G2/M phase of the cell cycle. Immunocytochemistry revealed loss of intact microtubule structure in cells treated with 7c and 7e. Docking of compounds 7c and 7e with tubulin suggested that the A-ring of the compounds occupies the colchicine binding site of tubulin, which coordinates with Cys241, Leu242, Ala250, Val318, Val328, and I378, and that the nitrovinyl side chain forms two hydrogen bonds with the main loop of the β-chain at Asn249 and Ala250.
Synthetic Communications | 2007
B. Sreedhar; P. Surendra Reddy
Abstract An ultrasound‐accelerated fast and efficient three‐component reaction for the regioselective synthesis of l,4‐disubstituted 1,2,3‐triazoles using different alkyl and allyl halides, terminal alkynes, and sodium azide in water at room temperature has been developed using CuI as catalyst. Ultrasonication dramatically decreases the reaction times.
Synthetic Communications | 2007
B. Sreedhar; P. Surendra Reddy; M. Madhavi
Abstract α‐Halogenation of various carbonyl compounds such as β‐keto‐esters, cyclic ketones, and lactams with N‐halosuccinamides (NBS, NCS, NIS) in the presence of DMSO proceeded very smoothly to give the corresponding α‐monohalogenated products in good to excellent yields with high selectivity under catalyst‐free conditions.
Synthetic Communications | 2010
P. Surendra Reddy; M. Amarnath Reddy; B. Sreedhar; M. V. Basaveswara Rao
An efficient method is described for the stereoselective synthesis of diorganyl chalcogenides from a variety of Baylis–Hillman acetates and diaryl chalcogens using palladium catalyst. This reaction is a convenient new method to produce unsymmetrical sulfides and selenides in good yields.
Journal of Molecular Catalysis A-chemical | 2006
K. Rajender Reddy; Nadakudity S. Kumar; P. Surendra Reddy; B. Sreedhar; M. Lakshmi Kantam
Tetrahedron Letters | 2005
B. Sreedhar; P. Surendra Reddy; B. Veda Prakash; A. Ravindra
Tetrahedron Letters | 2006
B. Sreedhar; P. Surendra Reddy; N. Sailendra Kumar
Tetrahedron Letters | 2007
B. Sreedhar; P. Surendra Reddy; C.S. Vamsi Krishna; P. Vijaya Babu
Tetrahedron Letters | 2007
B. Sreedhar; P. Surendra Reddy; M. Amarnath Reddy; B. Neelima; R. Arundhathi
Advanced Synthesis & Catalysis | 2010
M. Amarnath Reddy; P. Surendra Reddy; B. Sreedhar