P. Tranquilli Leali

Comparison in in-vivo response between a bioactive glass and a non-bioactive glass

AbstractThe authors report on the in-vivo comparison, in the rabbit, between the response to a bioactive glass and the response to a non-bioactive glass. Implants have been performed in muscle and bone. Two different glasses were investigated, namely B01 and I02. B01 is a glass designed to be degradable and resorbable and has a percentual molar composition of:

Histomorphological study of bone response to hydroxyapatite coating on stainless steel

SiO_2 49.6; P_2 O_5 2.7\% ;s + MgO + Na_2 O + K_2 O + Al_2 O_3

Biocompatibility and osteogenetic characteristics of new biocompatible glasses

47.7% with a 1 : 1 CaO/Na2O ratio. I02 is a sodium-calcium-silicate non-resorbable glass lacking P2O5 and has a percentual molar composition of:

Hydroxyapatite Surface Coatings for Biomaterials: A Report of a Multi-Centre Investigation–Brite-Euram Project BREU/0172C

SiO_2 70.7\% ; CaO + MgO + Na_2 O + K_2 O + Al_2 O_3

Austenitic Stainless Steel S350 for Surgical Implants

29.3%. In-vivo tests were planned as: (a) intramuscular implants of glass cylinders in the rectus femoris and retrievals took place at 2, 16 and 43 weeks; (b) intraosseus implants of glass cylinders in the distal femural canal and retrievals took place at 8 and 43 weeks. Histology and light microscopy analysis followed. Bioactive degradable glass elicits a favorable response both in muscle and bone; a gradual degradation process leads to disruption and partial resorption of the material and a tight apposition is promoted with the newly formed bone. The non-bioactive sodium-calcium-silicate glass (named I02) may elicit, like the bioactive degradable B01, a favorable response which is characterized by the absence of inflammatory or other adverse reactions; anyway it does not change its structure at an optical microscopic level and it does not promote any tight apposition with bone. ©2000 Kluwer Academic Publishers

POROUS TANTALUM MONOBLOCK ELLIPTICAL ACETABULAR CUP

The in-vivo response to a composite material obtained with polyetherimide (PEI) reinforced with carbon/glass fibers was investigated by histological methods by implanting cylinders in muscle and in bone of the New Zealand White rabbit. A common metallic alloy, widely used in orthopaedic surgery, was used as control (Stellite). The aim of the study was to analyze the biological response towards the surface of the material. Composite implants and metallic implants did not induce adverse or inflammatory reactions. The morphological picture produced was similar, in muscle and in bone, for both materials. In muscle, cylinders were confined by an extremely thin fibrous layer and the overall appearance of the muscular tissue was normal. In bone, cylinders were confined by a nearly annular rim of newly formed bone. From these data it is possible to derive that the response to PEI-based composite material is comparable with the response to metallic substrate and, then, the material can be suitable for clinical application. ©1999 Kluwer Academic Publishers