P. W. Davidson

Associations between maternal serum concentrations of polyunsaturated fatty acids and C - reactive protein among a high-fish eating cohort in the Republic of the Seychelles

Creactive protein (CRP) is an acute-phase protein secreted by the liver in response to inflammation. Circulating concentrations of n-3 polyunsaturated fatty acids (PUFA), particularly eicosapentaenoic acid (EPA) are known to exert anti-inflammatory effects. Studies have previously shown higher dietary intakes of n-3 PUFA and oily fish to be inversely associated with serum CRP concentrations, albeit in low fish-eating populations. Fewer studies have investigated these relationships in high fish-eating populations or in pregnant women. The aim of this study was to investigate associations of maternal serum concentrations of PUFA and reported fish consumption with serum concentrations of CRP within a high-fish eating cohort of pregnant women in the Republic of Seychelles. Serum samples were previously collected from pregnant women at 28 weeks gestation (n= 1160) as part of the Seychelles Child Development Study Nutrition Cohort 2 (SCDS NC2). These samples were analysed using the iLab 650 Chemistry Analyser to quantify serum CRP concentrations (μg/dl), using a CRP diagnostic kit. Data were available for the reported number of fish meals per week from Fish Use Questionnaires (FUQ) administered during pregnancy. Multiple linear regression analyses were performed to investigate associations of PUFA status and reported fish consumption with serum CRP concentrations, whilst adjusting for maternal BMI and maternal age at enrolment.

Polymorphisms in thioredoxin genes are associated with prenatal thyroid hormone status in a cohort of high fish-eating pregnant women

A. J. Yeates, T. Love, K. Engstrom, M. S. Mulhern, E.M. McSorley, G. Watson, G. E. Myers, E. van Wijngaarden, P.W. Davidson, C. Shamlaye, J. J. Strain and K. Broberg Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, University of Rochester, School of Medicine and Dentistry, NY, USA, Lund University, Sweden and Ministry of Health, Victoria, Mahé, Republic of Seychelles

Fish consumption and polyunsaturated fatty acid status of pregnant women in the Seychelles Child Development and Nutrition Study Cohort 2

A. J. Yeates, M. S. Mulhern, E. M. McSorley, J. M. W. Wallace, G. E. Watson, G. J. Myers, E. van Wijngaarden, C. Shamlaye, J. Henderson, S. W. Thurston, P. W. Davidson and J. J. Strain Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, University of Rochester, School of Medicine and Dentistry, NY, USA and Ministry of Health, Victoria, Mahé, Republic of Seychelles

Plasma total cysteine is a determinant of adiposity in healthy adolescents living in the Republic of Seychelles

A. J. McAfee, M. S. Mulhern, P. M. Ueland, E. M. McSorley, J. M. W. Wallace, G. E. Watson, G. E. Myers, E. van Wijngaarden, C. Shamlaye, P. W. Davidson and J. J. Strain Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK, Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway, University of Rochester, School of Medicine and Dentistry, NY, USA and Ministry of Health, Victoria, Mahe, Republic of Seychelles

Plasma phospholipid fatty acid status of 5-year-old children in the Seychelles Child Development Nutrition Study

A. J. McAfee, M. S. Barnes, J. J. Strain, P. W. Davidson, M. P. Bonham, E. M. McSorley, S. W. Thurston, J. M. W. Wallace, C. F. Shamlaye, G. Watson, G. J. Myers and T. W. Clarkson Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK, School of Medicine and Dentistry, University of Rochester, USA, Ministry of Health, Seychelles and Cornell University, USA and The Johns Hopkins Bloomberg School of Public Health, USA