Pa Keep
University College London
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Publication
Featured researches published by Pa Keep.
Nature Medicine | 1996
Richard H. J. Begent; M.J. Verhaar; Ka Chester; J.L. Casey; A.J. Green; M.P. Napier; L.D. Hopestone; N. Cushen; Pa Keep; C.J. Johnson; Robert E. Hawkins; A.J.W. Hilson; L Robson
We present a system for cancer targeting based on single–chain Fv (scFv) antibodies selected from combinatorial libraries, produced in bacteria and purified by using an engineered tag. Combinatorial libraries of scFv genes contain great diversity, and scFv antibodies with characteristics optimized for a particular task can be selected from them using filamentous bacteriophage. We illustrate the benefits of this system by imaging patients with carcinoembryonic antigen (CEA)–producing cancers using an iodine–123 labeled scFv anti–CEA selected for high affinity. All known tumor deposits were located, and advantages over current imaging technology are illustrated. ScFvs are produced in a cloned form and can be readily engineered to have localizing and therapeutic functions that will be applicable in cancer and other diseases.
Biochemical Journal | 2000
Mark K. Boehm; Adam L. Corper; Tommy Wan; Maninder K. Sohi; Brian J. Sutton; Jeremy D. Thornton; Pa Keep; Kerry A. Chester; Richard Begent; Stephen J. Perkins
The Journal of Nuclear Medicine | 1984
Alan J. Green; Richard H. J. Begent; Pa Keep; K. D. Bagshawe
The Journal of Nuclear Medicine | 1996
Marlies J. Verhaar; Pa Keep; Robert E. Hawkins; L Robson; J.L. Casey; Barbara Pedley; J Boden; Richard H. J. Begent; Kerry A. Chester
In: Begent, RHJAH and A, , (eds.) New Antibody technology and the Emergence of Useful Cancer Therapy. London: Royal Society of Medicine Press (1995) | 1995
Ka Chester; Rhj Begent; L Robson; Pa Keep; Rb Pedley; J Boden; Gm Boxer; Aj Green; P Michale; Gregory Paul Winter; O Cochet; Re and Hawkins
In: (pp. 16-). (1995) | 1995
Rhj Begent; Ka Chester; J. L. Casey; Aj Green; Mp Napier; L Hopestone; Pa Keep; L Robson; Dm Lane; Cj Johnson
In: (Proceedings) Proceedings BACR, Br J Cancer. (pp. 15-). (1994) | 1994
Ka Chester; Rhj Begent; L Robson; Pa Keep; Rb Pedley; J Boden; Gm Boxer; P Savage; Gregory Paul Winter; O Cochet
In: (pp. p. 198). (1994) | 1994
Ka Chester; Rhj Begent; L Robson; Pa Keep; Rb Pedley; J Boden; Gm Boxer; Aj Green; Gregory Paul Winter; O Cochet; Ref Hawkins
(1994) | 1994
Ka Chester; Rhj Begent; L Robson; Pa Keep; Rb Pedley; J Boden; Gm Boxer; Aj Green; P Michale; Gregory Paul Winter; O Cochet; Re and Hawkins
In: (pp. p. 556). (1984) | 1984
Rhj Begent; Aj Green; Ka Chester; Pa Keep; F Searle; K. D. Bagshawe
