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Chapter 1 Lamellarins: Isolation, activity and synthesis

Publisher Summary This chapter provides an overview on lamellarins—an important group of natural products isolated from marine invertebrates, such as sponges, mollusks, and tunicates. Lamellarins are a family of sea natural products with a broad therapeutic profile and are characterized for possessing important biological activities. More than 30 lamellarins have been characterized since the isolation of the first group of lamellarins. Several of lamellarins are in advanced pre-clinical phase testing for the treatment of different tumors. Syntheses of this family of molecules have been possible only by the use of the most modem synthetic protocols, mainly cross-coupling reagents, and cycloadditions. This chapter also discusses the structure of lamellarin.

1H NMR spectroscopy with internal and external standards for the quantification of libraries

A convenient and easy method based on 1H NMR spectroscopy with both external and internal standardsis described for the quantification of members of libraries.