Pablo Tutor-Ureta
Autonomous University of Madrid
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Publication
Featured researches published by Pablo Tutor-Ureta.
Annals of the Rheumatic Diseases | 2006
Susana Mellor-Pita; Maria Jesus Citores; Raquel Castejon; Pablo Tutor-Ureta; Miguel Yebra-Bango; José Luis Andreu; Juan A. Vargas
Current evidence indicates that regulatory T cells (Tregs) actively suppress autoreactive lymphocytes that escape central tolerance.1,2 Tregs are characterised by a high intensity CD25 constitutive expression3 on the surface of CD4 T lymphocytes, which distinguishes them from the non-regulatory CD4+CD25+ T lymphocytes.4 Because of their important role in the maintenance of tolerance, it has been suggested that Tregs are decreased in patients with systemic lupus erythematosus (SLE).5 We have quantified Tregs in patients with SLE and controls and evaluated their association with disease activity and treatment. Thirty three patients with SLE (26 women, 7 men) and 14 healthy volunteers matched for age and sex (11 women, 3 men) with a mean age of 39.9 and 36 years, respectively, were studied. All patients fulfilled at least four of the American College of Rheumatology 1982 revised criteria for the classification of SLE.6 Disease activity at the time of blood sampling was assessed using the SLE Disease Activity Index (SLEDAI).7 …
Cytometry Part B-clinical Cytometry | 2009
Susana Mellor-Pita; Maria Jesus Citores; Raquel Castejon; Miguel Yebra-Bango; Pablo Tutor-Ureta; Silvia Rosado; José Luis Andreu; Juan A. Vargas
To investigate the contribution of T lymphocytes and monocytes to cytokine production in systemic lupus erythematosus (SLE).
Cytometry Part B-clinical Cytometry | 2006
Pablo Tutor-Ureta; Maria Jesus Citores; Raquel Castejon; Susana Mellor-Pita; Miguel Yebra-Bango; Yolanda Romero; Juan A. Vargas
Not all the patients with sarcoidosis need pharmacological therapy, and the decision to start therapy is based mainly on clinical conditions. The aim of this study was to evaluate the prognostic value of the leukocyte and lymphocyte subpopulations in the bronchoalveolar lavage fluid from these patients.
Gene | 2016
Elena Martínez-Robles; Miguel Yebra-Bango; Susana Mellor-Pita; Pablo Tutor-Ureta; Juan A. Vargas; Maria Jesus Citores
Genetic variants of endosomal toll like receptors (TLR) have been associated with many infectious, autoimmune and inflammatory diseases, but few studies have been reported in the Spanish population. The aim of this study was to describe the allelic and genotypic distributions of some common nucleotide substitutions of endosomal TLRs in healthy Spanish women and to compare them with those already published in other population groups. Nine substitutions were analysed in 150 DNA samples from 150 Spanish, non-related healthy females: TLR3 rs3775291 and rs5743305; TLR7 rs179008 and rs5743781; TLR8 rs3764880 and TLR9 rs187084, rs5743836, rs352139 and rs352140. Genotyping was carried out by real time PCR and melting curve analysis in a LightCycler 480. A systematic review was performed in order to compare the genotypic distributions in our cohort with those previously published in other population groups. The comparative study was performed with the two tailed Fishers test or the Yates continuity correction for the Chi-square test when appropriate. No homozygotes for rs5743781 in TLR7 were found, and rs352139 and rs352140 of TLR9 were in strong linkage disequilibrium. Genotype distributions in endosomal TLR are similar to other Spanish series previously reported. As expected, most differences were found when comparing our distributions with Asiatics, but differences were also found with other Caucasian populations. Since there are significant variations in genotypic distributions of TLRs in both interracial groups and within the same ethnic group, to carry out studies of disease susceptibility in more restricted groups is mandatory.
Revista Clinica Espanola | 2011
Pablo Tutor-Ureta; M. Jiménez; C. Bellas; G. Goizueta San Martín; Miguel Yebra-Bango; Juan A. Vargas
1 r N c El síndrome de Churg-Strauss es una enfermedad multisistémica caracterizada por la presencia de rinitis alérgica, asma y eosinofilia periférica1. Los órganos más frecuentemente afectados son el pulmón (90-100%) y la piel (51-70%), junto con la afectación del sistema nervioso periférico en forma de mononeuritis múltiple (66-76%)1,2. Las manifestaciones musculoesqueléticas son posibles durante la fase activa de la enfermedad, siendo más raras en otros momentos1. La afectación muscular en forma de miositis en un síndrome de Churg-Strauss es inusual, habiéndose publicado sólo 3 casos hasta la fecha como forma de presentación clínica3—5. Presentamos el caso de un paciente con clínica indicativa de polimiositis como primera manifestación de un síndrome de Churg-Strauss.
Revista Clinica Espanola | 2005
Pablo Tutor-Ureta; Miguel Yebra-Bango; S Mellor-Pita; Salas-Antón C
Mujer de 51 anos con antecedentes de un tumor carcinoide ileal con metastasis hepaticas de tres anos de evolucion (fig. 1) que ingresa por diarrea y enrojecimiento facial episodico. El ecocardiograma revela una insuficiencia tricuspide moderada y se realiza una ileocolectomia izquierda seguida de tratamiento con somatostatina que consigue una respuesta sintomatica parcial. En la actualidad acude por la aparicion de unas lesiones cutaneas fotosensibles, hiperpigmentadas y descamativas bilaterales, distribuidas de forma simetrica en codos, tobillos y nuca (fig. 2). Los niveles de acido 5-hidroxiindolacetico en la orina son elevados (296 mg/24 horas). La biopsia de las lesiones cutaneas apoyo la sospecha diagnostica.
Seminars in Arthritis and Rheumatism | 2007
Mónica Fernández-Castro; Susana Mellor-Pita; Maria Jesus Citores; Pilar Muñoz; Pablo Tutor-Ureta; Lucia Silva; Juan A. Vargas; Miguel Yebra-Bango; José Luis Andreu
Enfermedades Infecciosas Y Microbiologia Clinica | 2006
Pablo Tutor-Ureta; Susana Mellor-Pita; Miguel Yebra-Bango; Juan A. Vargas
Medicina Clinica | 2005
Pablo Tutor-Ureta; Miguel Yebra-Bango; Clara Salas-Antón; José Luis Andreu
Medicina Clinica | 2018
Maria Luisa Martin Jiménez; Susana Mellor-Pita; Pablo Tutor-Ureta