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Paj Janssen

Rega Institute for Medical Research

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Featured researches published by Paj Janssen.

ChemInform | 1976

SYNTHESIS OF α-METHYL-4-(2-THIENYLCARBONYL)BENZENEACETIC ACID, SUPROFEN, AND DERIVATIVES

P. G. H. Van Daele; Jozef Martin Boey; V. K. Sipido; M. F. L. De Bruyn; Paj Janssen

A series of compounds with general structure Het-CO-Ar-CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. Alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid (compound III-1, suprofen) was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America | 1991

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

Zeger Debyser; Rudi Pauwels; K. Andries; Jan Desmyter; M. Kukla; Paj Janssen; E. De Clercq

Molecular Pharmacology | 1992

Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4] benzodiazepin-2(1H)-one and -thione compounds

Zeger Debyser; Rudi Pauwels; Koen Andries; Jan Desmyter; Yves Engelborghs; Paj Janssen; E. De Clercq

Journal of Organic Chemistry | 1966

Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazo[5,1-c] [1,4] oxazines

Erik F. Godefroi; C.A.M. Van der Eycken; Paj Janssen

Antiviral Research | 1993

Real-time characterization of the interaction of HIV-1-specific inhibitors with their binding site at the HIV-1 reverse transcriptase (RT) using surface plasmon resonance and biosensor technology

Rudi Pauwels; B Persson; Lg Fägerstam; L Öfas; Koen Andries; K De Vreese; P Van Daele; Zeger Debyser; R Bhikhabhai; B Strandberg; Jan Desmyter; Paj Janssen; Erik De Clercq

Journal of Cellular Biochemistry | 1992

Comparison of RT gene sequences from HIV-1 strains with different sensitivity to TIBO derivatives

Anne-Mieke Vandamme; Zeger Debyser; Koen Andries; Paj Janssen; Rudi Pauwels; Jan Desmyter; Erik De Clercq

Archive | 1993

Isolation and characterization of clinical HIV-1 strains with different sensitivities to TIBO derivatives

Anne-Mieke Vandamme; Zeger Debyser; Rudi Pauwels; K De Vreese; P. Goubau; Jozef Anné; Brian Gazzard; Koen Andries; Paj Janssen; Jan Desmyter; Erik De Clercq

Archive | 1993

Rapid emergence of HIV-1 resistance to R82913 in only a minority of treated patients

Anne-Mieke Vandamme; Zeger Debyser; Rudi Pauwels; Koen Andries; Paj Janssen; Jan Desmyter; Erik De Clercq

Recent advances in the chemistry of anti-infective agents | 1992

Discovery and development of TIBO as a potential anti-AIDS therapeutic

Michael Joseph Kukla; Henry J. Breslin; E. de Clercq; Rudi Pauwels; Koen Andries; Paj Janssen

Archive | 1992

Potent and highly selective HIV-1 specific inhibition by a new series of alfa- anilino-phenylacetamide (alfa-APA) derivatives targeted at HIV-1 RT

Rudi Pauwels; Koen Andries; Dominique Schols; P Van Daele; Zeger Debyser; Mac Janssen; Anne-Mieke Vandamme; K De Vreese; Jan Desmyter; Erik De Clercq; Paj Janssen

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