Pakaphan Kiatchoosakun
Khon Kaen University
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Publication
Featured researches published by Pakaphan Kiatchoosakun.
Pediatric Research | 2002
Pakaphan Kiatchoosakun; Ismail A. Dreshaj; Jalal M. Abu-Shaweesh; Musa A. Haxhiu; Richard J. Martin
We have previously documented anatomic and functional relationships between ventilatory and autonomic neural output. Therefore, we hypothesized in this study that hypoxia-induced changes in respiratory neural output are associated with changes in autonomic regulation of lower esophageal sphincter (LES) pressure. Respiratory neural output, heart rate, and LES pressure were measured before and during a 3-min exposure to 8% oxygen (balance nitrogen) in 12 3- to 7-d-old piglets. Respiratory neural output was determined from diaphragmatic electromyogram and LES pressure from an esophageal catheter. Studies were repeated after atropine administration in eight animals. Hypoxic exposure resulted in significant increases in diaphragmatic amplitude, respiratory rate, and minute diaphragmatic activity as well as heart rate. The biphasic response of diaphragm amplitude peaked at 1 min, whereas the responses of respiratory frequency and heart rate were sustained. Hypoxia caused a 50% increase in LES pressure (p < 0.05), which was eliminated by i.v. atropine administration. Development of apnea during subsequent hyperoxic exposure was always followed by a decline in LES pressure. Hypoxia-induced increase in respiratory neural output and accompanying increase in heart rate are associated with enhanced constrictive output to the LES. Blockade by atropine implicates a peripheral cholinergic mechanism for this LES response. We speculate that whereas hypoxia in the presence of enhanced respiratory neural output seems to be protective against reflux, decreased respiratory drive and accompanying apnea may be associated with a decline in LES tone and predispose to gastroesophageal reflux.
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2004
Pope Kosalaraksa; Janthep P; Junya Jirapradittha; Sukanya Taksaphan; Pakaphan Kiatchoosakun
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2012
Pakaphan Kiatchoosakun; Wichitra Suphadun; Junya Jirapradittha; Kwanchanok Yimtae; Panida Thanawirattananit
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2012
Rosawan Areemit; Jadsada Thinkhamrop; Pensri Kosuwon; Pakaphan Kiatchoosakun; Sumitr Sutra; Kaewjai Thepsuthammarat
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2005
Pakaphan Kiatchoosakun; Pope Kosalaraksa; Junya Jirapradittha; Sukanya Taksaphan; Sompon Tassniyom
Asian Biomedicine | 2011
Kittiphop Somboonnithiphol; Ouyporn Panamonta; Pakaphan Kiatchoosakun; Junya Jirapradittha; Manat Panamonta; Pagakrong Lumbiganon
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2003
Pakaphan Kiatchoosakun; Junya Jirapradittha; Sukanya Taksaphan; Jamaree Teeratakulpisarn; Benjaporn Nitinavakarn; Cherdchai Tantisirin
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2014
Suteera Pradubwong; Sumalee Pongpagatip; Pornpen Pathumwiwatana; Pakaphan Kiatchoosakun; Manat Panamonta; Bowornsilp Chowchuen
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2014
Pakaphan Kiatchoosakun; Jirapradittha J; Panthongviriyakul Mc; Tueanjit Khampitak; Puangrat Yongvanit; Patcharee Boonsiri
Journal of the Medical Association of Thailand Chotmaihet thangphaet | 2013
Piyamas Saksiriwuttho; Thawalwong Ratanasiri; Chatuporn Doankum; Pilaiwan Kleebkaew; Pakaphan Kiatchoosakun