Palakuri Ramesh

Indium/Fe(III) – mediated regioselective β-cross-coupling aldol type addition reaction of activated alkenes with isatins/isatinimines in aqueous media

A highly efficient and regioselective β-cross coupling aldol type addition reaction of activated alkenes with isatin/isatinimine derivatives in the presence of Indium/Fe(III) in THF/H2O at room temperature is described. Our synthetic protocol explores a broad substrate scope and smoothly proceeds under base-free conditions. The resulting products are obtained in a short reaction time with moderate to high yields. This is the first example of Mannich-type coupling of isatinimines with activated alkenes to afford the alkyl 3-(2-oxo-3-(phenylamino)indolin-3-yl)propanoates and 3-(3-oxoalkyl)-3-(phenylamino)indolin-2-ones.

A Ru(III) – catalyzed α-cross-coupling aldol type addition reaction of activated olefins with isatins

A α-cross-coupling aldol type addition reaction activated olefins with isatins has been described in the presence of ruthenium(III) chloride and tributyltin hydride (TBTH) at room temperature. This method is found to work consistently for the delivering of ene-carbonyl coupled products in good to excellent yields with moderate to acceptable selectivity. The substrate scope of the present method was briefly discussed.