Pamela M. Lindroos
National Institutes of Health
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Publication
Featured researches published by Pamela M. Lindroos.
American Journal of Physiology-lung Cellular and Molecular Physiology | 1998
James C. Bonner; Pamela M. Lindroos; Annette B. Rice; Cindy R. Moomaw; Daniel L. Morgan
Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells. Induction of the PDGF receptor-alpha (PDGF-R alpha) in vitro enhances PDGF-induced mitogenesis and chemotaxis. Thus we investigated whether the PDGF-R alpha is induced in vivo during pulmonary fibrogenesis using a vanadium pentoxide (V2O5) model of lung injury. PDGF-R alpha mRNA expression was induced 24 h postinstillation. PDGF-R beta mRNA was constitutively expressed and did not increase. Western blotting showed upregulation of PDGF-R alpha protein by 48 h, and immunohistochemical analysis localized PDGF-R alpha primarily in mesenchymal cells residing within fibrotic lesions. Upregulation of PDGF-R alpha in vivo preceded mesenchymal cell hyperplasia (3-7 days) and collagen deposition by day 15. Supernatants from alveolar macrophages treated with V2O5 in vitro released upregulatory activity for PDGF-R alpha on cultured lung myofibroblasts, and this activity was blocked by the interleukin-1-receptor antagonist. These data suggest that interleukin-1 beta-mediated induction of PDGF-R alpha in vivo is important to lung myofibroblast hyperplasia during fibrogenesis.
American Journal of Respiratory Cell and Molecular Biology | 1998
James C. Bonner; Annette B. Rice; Pamela M. Lindroos; Patricia O. O'Brien; Kevin L. Dreher; Irma Rosas; Ernesto Alfaro-Moreno; Alvaro Osornio-Vargas
American Journal of Respiratory Cell and Molecular Biology | 1997
Pamela M. Lindroos; P G Coin; Annette Badgett; Daniel L. Morgan; James C. Bonner
American Journal of Respiratory Cell and Molecular Biology | 1995
James C. Bonner; Annette Badgett; Pamela M. Lindroos; Alvaro Osornio-Vargas
American Journal of Respiratory Cell and Molecular Biology | 1995
Pamela M. Lindroos; P G Coin; Alvaro Osornio-Vargas; James C. Bonner
American Journal of Respiratory Cell and Molecular Biology | 1995
Joseph A. Lasky; Patrick G. Coin; Pamela M. Lindroos; Lawrence E. Ostrowski; Arnold R. Brody; James C. Bonner
Journal of Immunology | 1996
P. G. Coin; Pamela M. Lindroos; G. S. J. Bird; Alvaro Osornio-Vargas; Victor L. Roggli; James C. Bonner
American Journal of Physiology-lung Cellular and Molecular Physiology | 1996
James C. Bonner; Annette Badgett; Pamela M. Lindroos; P. G. Coin
American Journal of Respiratory Cell and Molecular Biology | 1999
James E. Boyle; Pamela M. Lindroos; Annette B. Rice; Limin Zhang; Darryl C. Zeldin; James C. Bonner
American Journal of Physiology-lung Cellular and Molecular Physiology | 1996
Alvaro Osornio-Vargas; Pamela M. Lindroos; P. G. Coin; Annette Badgett; Norma Hernández-Rodríguez; James C. Bonner