Paola Cappellano
Federal University of São Paulo
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Publication
Featured researches published by Paola Cappellano.
Clinical Infectious Diseases | 2004
Claudio Viscoli; Marco Machetti; Paola Cappellano; Barbara Bucci; Paolo Bruzzi; Maria Teresa Van Lint; Andrea Bacigalupo
At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P<.001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.
Clinical Microbiology and Infection | 2014
Marisa R. Nucci; Kieren A. Marr; Maria J.G.T. Vehreschild; C.A. De Souza; E. Velasco; Paola Cappellano; F. Carlesse; F. Queiroz-Telles; Donald C. Sheppard; A. Kindo; Simone Cesaro; Nelson Hamerschlak; Cristiana Solza; Werner J. Heinz; M. Schaller; Angelo Atalla; S. Arikan-Akdagli; Hartmut Bertz; C. Galvão Castro; Raoul Herbrecht; Martin Hoenigl; G. Härter; N. E U Hermansen; A. Josting; Livio Pagano; M. J C Salles; S. B. Mossad; D. Ögünç; Alessandro C. Pasqualotto; V. R. Araujo
Invasive fusariosis (IF) has been associated with a poor prognosis. Although recent series have reported improved outcomes, the definition of optimal treatments remains controversial. The objective of this study was to evaluate changes in the outcome of IF. We retrospectively analysed 233 cases of IF from 11 countries, comparing demographics, clinical findings, treatment and outcome in two periods: 1985-2000 (period 1) and 2001-2011 (period 2). Most patients (92%) had haematological disease. Primary treatment with deoxycholate amphotericin B was more frequent in period 1 (63% vs. 30%, p <0.001), whereas voriconazole (32% vs. 2%, p <0.001) and combination therapies (18% vs. 1%, p <0.001) were more frequent in period 2. The 90-day probabilities of survival in periods 1 and 2 were 22% and 43%, respectively (p <0.001). In period 2, the 90-day probabilities of survival were 60% with voriconazole, 53% with a lipid formulation of amphotericin B, and 28% with deoxycholate amphotericin B (p 0.04). Variables associated with poor prognosis (death 90 days after the diagnosis of fusariosis) by multivariable analysis were: receipt of corticosteroids (hazard ratio (HR) 2.11, 95% CI 1.18-3.76, p 0.01), neutropenia at end of treatment (HR 2.70, 95% CI 1.57-4.65, p <0.001), and receipt of deoxycholate amphotericin B (HR 1.83, 95% CI 1.06-3.16, p 0.03). Treatment practices have changed over the last decade, with an increased use of voriconazole and combination therapies. There has been a 21% increase in survival rate in the last decade.
Clinical Microbiology and Infection | 2013
Marcio Nucci; Marcia Garnica; Ana Beatriz Firmato Glória; D.S. Lehugeur; V.C.H. Dias; Leonardo Carvalho Palma; Paola Cappellano; Kleber Yotsumoto Fertrin; F. Carlesse; Belinda Pinto Simões; M.D. Bergamasco; C.A. Cunha; Adriana Seber; M.P.D. Ribeiro; F. Queiroz-Telles; M.L.M. Lee; Maria de Lourdes Lopes Ferrari Chauffaille; Lucia Mariano da Rocha Silla; C.A. De Souza; Arnaldo Lopes Colombo
Invasive fungal disease (IFD) shows distinct regional incidence patterns and epidemiological features depending on the geographic region. We conducted a prospective survey in eight centres in Brazil from May 2007 to July 2009. All haematopoietic cell transplant (HCT) recipients and patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS) were followed from admission until 1 year (HCT) or end of consolidation therapy (AML/MDS). The 12-month cumulative incidence (CI) of proven or probable IFD was calculated, and curves were compared using the Grey test. Among 237 AML/MDS patients and 700 HCT recipients (378 allogeneic, 322 autologous), the 1-year CI of IFD in AML/MDS, allogeneic HCT and autologous HCT was 18.7%, 11.3% and 1.9% (p <0.001), respectively. Fusariosis (23 episodes), aspergillosis (20 episodes) and candidiasis (11 episodes) were the most frequent IFD. The 1-year CI of aspergillosis and fusariosis in AML/MDS, allogeneic HCT and autologous HCT were 13.4%, 2.3% and 0% (p <0.001), and 5.2%, 3.8% and 0.6% (p 0.01), respectively. The 6-week probability of survival was 53%, and was lower in cases of fusariosis (41%). We observed a high burden of IFD and a high incidence and mortality for fusariosis in this first multicentre epidemiological study of IFD in haematological patients in Brazil.
Transplant Infectious Disease | 2010
Malgorzata Mikulska; V. Del Bono; Roberta Prinapori; L. Boni; A M Raiola; F. Gualandi; M T Van Lint; Alida Dominietto; Teresa Lamparelli; Paola Cappellano; A. Bacigalupo; Claudio Viscoli
M. Mikulska, V. Del Bono, R. Prinapori, L. Boni, A.M. Raiola, F. Gualandi, M.T. Van Lint, A. Dominietto, T. Lamparelli, P. Cappellano, A. Bacigalupo, C. Viscoli. Risk factors for enterococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis 2010: 12: 505–512. All rights reserved
BMC Infectious Diseases | 2013
Liana Carballo Menezes; Talita Trevizani Rocchetti; Karen de Castro Bauab; Paola Cappellano; Milene Gonçalves Quiles; Fabianne Carlesse; José Salvador Rodrigues de Oliveira; Antonio Carlos Campos Pignatari
BackgroundEarly identification of pathogens and antimicrobial resistance in bloodstream infections (BSIs) decreases morbidity and mortality, particularly in immunocompromised patients. The aim of the present study was to compare real-time polymerase chain reaction (PCR) with commercial kits for detection of 17 pathogens from blood culture (BC) and 10 antimicrobial resistance genes.MethodsA total of 160 BCs were taken from bone marrow transplant patients and screened with Gram-specific probes by multiplex real-time PCR and 17 genus-specific sequences using TaqMan probes and blaSHV, blaTEM, blaCTX, blaKPC, blaIMP, blaSPM, blaVIM, vanA, vanB, and mecA genes by SYBR Green.ResultsTwenty-three of 33 samples identified by phenotypic testing were concordantly positive by BC and real-time PCR. Pathogen identification was discordant in 13 cases. In 12 of 15 coagulase-negative staphylococci, the mecA gene was detected and four Enterococcus spp. were positive for vanA. Two blaCTX and three blaSHV genes were found by quantitative PCR. The blaKPC and metallo-β-lactamase genes were not detected. Five fungal species were identified only by real-time PCR.ConclusionsReal-time PCR could be a valuable complementary tool in the management of BSI in bone marrow transplants patients, allowing identification of pathogens and antimicrobial resistance genes.
Revista Brasileira De Hematologia E Hemoterapia | 2010
Marcia Garnica; Clarisse Martins Machado; Paola Cappellano; Viviane V. H. Carvalho; Andrea Nicolato; Clovis Arns da Cunha; Marcio Nucci
Infectious complications following stem cell transplantation are frequent and associated with high morbidity and mortality. Several factors related to the transplant procedure, such as type of transplant, the source of stem cells, the utilization of alternative donors are important determinants of the immune status of the host, and impact on the risk of infection. In this section we will discuss the different approaches for monitoring patients at risk and diagnosing and treating infectious complications in three time periods: before transplant, during neutropenia, and after engraftment.
Brazilian Journal of Infectious Diseases | 2018
Ingvar Ludwig Augusto Souza; Milene Gonçalves Quiles; Bruno Cruz Boettger; Antonio Carlos Campos Pignatari; Paola Cappellano
Abstract Febrile Neutropenia represents a medical emergency and the use of appropriate antimicrobial therapy is essential for a better outcome. Although being time-consuming, conventional cultures and antimicrobial susceptibility tests remain the golden standard practices for microbiology identification. Final reports are typically available within several days. Faster diagnostic tools, such as species identification trough Matrix Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) and molecular techniques might help to shorten time to diagnostic and also guide definitive therapy in this scenario. Here we present a case in which the use of a diagnostic molecular workflow combining MALDI-TOF and real-time PCR for relevant genes codifying antibiotic resistant integrated with instant communication report, led to a tailored and more appropriate treatment in a patient presenting with febrile neutropenia.
Diagnostic Microbiology and Infectious Disease | 2017
Ana Carolina Ramos; Lygia Schandert; Cecilia G. Carvalhaes; Rafael Affini Martins; Paola Cappellano; Flávia Ribeiro Machado; Ana Cristina Gales
The performance of EasyQ KPC assay was evaluated for the first time for blaKPC detection directly from surveillance rectal swabs without broth enrichment. Using conventional polymerase chain reaction as gold standard method, EasyQ KPC and culture-based molecular tests demonstrated a sensitivity/specificity of 100%/87.3% and 83.3%/98.2%, respectively.
New Microbiologica | 2007
Paola Cappellano; Claudio Viscoli; Paolo Bruzzi; Maria Teresa Van Lint; Carlos Alberto Pires Pereira; Bacigalupo A
PLOS ONE | 2014
Marcio Nucci; Fabianne Carlesse; Paola Cappellano; Andrea G. Varon; Adriana Seber; Marcia Garnica; Simone A. Nouér; Arnaldo Lopes Colombo
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Maria de Lourdes Lopes Ferrari Chauffaille
Federal University of São Paulo
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