Paolo Cabella

Multigram-scale production of aliphatic carboxylic acids by oxidation of alcohols with Acetobacter pasteurianus NCIMB 11664

Acetobacter pasteurianus NCIMB 11664 was selected for multigram-scale production of different aliphatic carboxylic acids through oxidation of the corresponding alcohols after screening different acetic acid bacteria. Continuous production was carried out using an air-lift reactor, with overall yields of 1-propionic, 1-butyric, 2-methyl-1-butyric and 3-methyl-1-butyric acids ranging from 45 to 61 g dm−3. ©1997 SCI

Biogeneration of gamma nonanolide from coriolic acid in Pichia stipitis and Pichia ohmeri

Abstractγ-nonanolide in the (R) enantiomeric form is obtained, close to (R) δ-decanolide, as major transformation product of (R) coriolic acid in Pichia stipitis; feeding experiments of the (S) enantiomer lead to δ-decanolide as major metabolite

Stereochemistry of the conversion of (R) coriolic acid into δ-decanolide in Cladosporium suaveolens

SummaryIn growing cultures of Cladosporium suaveolens (R) coriolic acid (3) is converted into 5-decanolide enriched in the (S) enantiomer (2) (ca. 0.4 ee), while recovered coriolic acid shows the same enantiomeric composition of the precursor, as indicated by NMR studies onto a set of (+)-MTPA derivatives.

Computer applications in food flavour research

Abstract Computer-assisted methods for improving research and production in a food-flavour company are described. Methods of experimental design are used in planning experiments. Special programs are used for identification of components through correlation of mass spectra and gas chromatographic retention indices, and for the design of new synthetic routes. In flavour creation, a data base containing qualitative and quantitative information on flavours, relevant legislation and organoleptic properties of components, can be searched selectively in attempts to improve flavours and to identify better combinations of substances. A computer-assisted production system is described which ensures complete qualitative and quantitative control.