Paolo Manzini

Phytochemical investigations on Artemisia alba Turra growing in the North-East of Italy

Abstract Artemisia alba Turra (Asteraceae) is an Euro-Mediterranean plant used in Veneto (North-East of Italy) as traditional medicine for the treatment of various diseases. A. alba is a taxonomically problematic species, characterised by common polymorphism leading to a quite high variability in secondary metabolites content. Nonetheless, the phytochemical knowledge on its phytoconstituents, especially non-volatile components, is limited. In the present paper, the phytochemical composition of a tincture obtained from the aerial parts of A. alba growing in Veneto is presented. Extensive chromatographic separations led to the isolation of three new sesquiterpene derivatives, whose structures were elucidated by 1D and 2D NMR experiments and mass spectrometry. Furthermore, flavonoid composition and volatile constituents of the tincture of A. alba were preliminary studied by HPLC–MSn and GC–MS, respectively.

Psoralen derivatives as inhibitors of NF-\upkappa \hbox {B/DNA} interaction: the critical role of the furan ring

Simplified analogues of previously reported NF-

Synthesis and antiproliferative activity of furocoumarin isosters.

\upkappa \hbox {B/DNA}

Methylangelicins: structure activity studies on the role of methyl groups present in 3,4 and 4',5' photoreactive sites.

κB/DNA interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-

A new access to quinazolines from simple anilines

\upkappa \hbox {B}

Methylpyranochromones and methylbenzodipyranones: new potential photoreagents towards DNA

κB.Graphical abstract