Paramjeet Kaur

Conformations of peptides containing Z-alpha,beta-dehydroleucine (delta ZLeu). A comparison of Boc-Pro-delta ZLeu-Gly-NHEt and Boc-Pro-delta ZPhe-Gly-NHEt.

Two tripeptides of the type Boc-Pro-delta ZX-Gly-NHEt (where X = Leu, Phe) have been synthesized and their solution conformations investigated by 270 MHz 1H n.m.r. and i.r. spectroscopy. These conformational studies indicated that delta ZLeu, similar to delta ZPhe, has a strong tendency to stabilize folded Type II beta-turn conformations when present at i + 2 position.

Universal T helper cell determinants enhance immunogenicity of a Plasmodium falciparum merozoite surface antigen peptide.

Formyl-Met-Leu-{\Delta}^z-Phe-Ome

Synthesis, crystal structure, and molecular conformation of peptide N-Boc-L-Pro-dehydro-Phe-L-Gly-OH

, an analog of the chemotactic tripeptide Formyl-Met-Leu-Phe has been synthesized to evaluate the effect of substitution of \alpha, \beta-dehydrophenylalanine on activity and conformation. The analog peptide shows high biological activity in stimulating superoxide production by rabbit neutrophils. An NMR analysis of the solution conformation of the

Crystal structure and molecular conformation of the peptide N-Boc-L-Gly-dehydro-Phe-NHCH3

{\Delta}^z-Phe

Conformations of dehydrophenylalanine containing peptides: nmr studies of an acyclic hexapeptide with two delta Z-Phe residues

analog, using nuclear Overhauser effects and comparisons with the corresponding saturated peptides, favours a significant population of extended backbone conformations.