Pariket M. Dubal

Sinonasal malignancies: A population-based analysis of site-specific incidence and survival

Sinonasal malignancies vary in behavior according to histology and anatomical location. Incidence, survival, and optimal treatment for these lesions are thus uncertain in various cases. Our objective was to utilize a national population‐based registry to identify the most common sinonasal histopathologies by anatomical site, and subsequently analyze the data by incidence trends, survival rates, patient demographics, and treatment modalities.

Laryngeal chondrosarcoma: a population-based analysis.

Laryngeal chondrosarcoma (LC) is a rare entity, reportedly comprising less than 1% of all laryngeal tumors. Consequently, the incidence and survival of patients with this slow‐growing tumor has been difficult to study. Our objective was to evaluate incidence, organized by patient demographics, as well as long‐term survival trends of this malignancy using a population‐based database.

A comparative population‐based analysis of sinonasal diffuse large B‐cell and extranodal NK/T‐cell lymphomas

Diffuse large B‐cell lymphoma (DLBCL) and extranodal natural killer/T‐cell lymphoma (ENKTL) are aggressive tumors. ENTKL is very rare in the United States and often affects the nasal cavity and paranasal sinuses; DLBCL, although more common, rarely occurs in these locations. Our study aims to compare incidence and survival of these lymphomas in the sinonasal cavity.

Squamous cell carcinoma of the maxillary sinus: A population‐based analysis

Squamous cell carcinoma (SCC) accounts for > 90% of head and neck cancers and 60% to 75% of malignancies of the paranasal sinuses. The most commonly affected paranasal sinus is the maxillary. Epidemiologic, incidence, and survival trends have been studied for maxillary sinus SCC (MSSCC), but far less is known about its metastatic potential.

Laryngeal Verrucous Carcinoma: A Population-Based Analysis.

Objective Verrucous carcinoma of the larynx (VCL) is a rare entity with reportedly favorable prognosis. Current analyses are limited primarily to case reports and case series, thus making a population-based analysis useful in characterizing frequency, incidence, and survival trends to guide clinical diagnosis and decision making. Study Design Analysis of the National Cancer Institute’s SEER (Surveillance, Epidemiology, and End Results) database. Methods Cases of VCL diagnosed between 1973 and 2011 were searched in the SEER database. Analysis was carried out with respect to patient demographics, tumor characteristics, incidence, treatment modality, and survival. Results In sum, 516 patients with VCL were identified. Males composed 88.4% of cases. Whites accounted for 88.4% of cases, with 8.1% of cases occurring in black patients. Most cases (79.7%) arose in the glottis, a statistically significant predilection when compared with other laryngeal malignancies (P < .0001). Incidence of VCL decreased from 2000 to 2011, with an annual percent change of −5.4%. Overall 1-, 5-, and 10-year disease-specific survival for VCL was 97.5%, 88.0%, and 77.4%, while 1-, 5-, and 10-year relative survival was 98.1%, 85.5%, and 74.2%, respectively. Surgery seemed to confer better prognosis when compared with other treatment modalities. Conclusions This large population-based analysis of VCL demonstrates that this entity has a good prognosis, arises in the glottis, and is decreasing in incidence. Five-year survival seems highest when surgery is utilized. However, this finding may be subject to selection bias in high-stage lesions.

Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival

Laryngeal spindle cell carcinoma (LSpCC) is a rare variant of squamous cell carcinoma. Surgery is the reported mainstay of treatment, but previous analyses failed to demonstrate survival outcomes by therapeutic modality. This study aims to carry out the largest population‐based analysis of this histology to determine tumor characteristics, incidence, survival, and prognostic indicators.

Laryngeal chondrosarcoma: A systematic review of 592 cases

Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes.

Squamous cell carcinoma of the nasal cavity: A population-based analysis

Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population‐based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes.

Sinonasal neuroendocrine carcinoma: a population-based analysis of incidence and survival.

Sinonasal neuroendocrine carcinoma (SNEC) is a rare, aggressive tumor usually associated with a poor prognosis. This study analyzes the clinicopathological characteristics and survival outcomes of SNEC using population‐based data.

Laryngeal adenoid cystic carcinoma: A population-based perspective

Adenoid cystic carcinoma (ACC) occurs infrequently in the larynx. Consequently, no large samples describing its clinical behavior are available in the literature. Our objective was to use a nationally representative population‐based resource to evaluate clinical behavior, patient demographics, and outcomes among patients diagnosed with laryngeal ACC (LACC).