Parina Hassanaly

Applications of Phase Transfer Catalysis in Heterocyclic Chemistry

Publisher Summary Phase transfer catalysis (PTC) methodology has already gained wide application in the chemistry of heterocyclic compounds. Most of such reactions were or can be carried out under traditional conditions, but PTC usually increases the yields and purity of the products, and provides a much simpler procedure for the reactions and for the isolations of the products. The main advantages connected with the application of PTC in heterocyclic chemistry are the same as for the general application of this methodology. PTC more generally, applications of twophase systems, is one of the most important recent methodological developments in organic synthesis. PTC reactions can be carried out without organic solvents or, if necessary, using solvents in small quantities sufficient to dissolve the reactants. Besides the application of this technique for synthesis and transformations of a variety of heterocyclic systems on a laboratory scale, PTC is used for manufacturing heterocyclic compounds for pharmaceutical, plant protection, or other applications. It is important because it simplifies procedures, eliminates expensive, inconvenient, and dangerous reactants and solvents, and also allows one to perform many reactions that otherwise proceed unsatisfactory or do not proceed at all.

SELECTIVE S-ALKYLATION IN PHASE TRANSFER CATALYSIS OF 2-PYRIDINE-, -PYRIMIDINE- AND BENZOXAZOLE-THIONE

Abstract Alkylation via phase transfer catalysis of several ambident anions of the |N–C–S|− type leads exclusively to S-substitution. Yields obtained are better or equal to those given by conventional methods and experimental work-up is very much simplified compared to the latter.

Effects of Substituant in Imidazolic Series Study by Magnetic Nuclear Resonance of Carbon 13

Abstract In order to connect the anomalies of reactivity and the physicochemical phenomena of discontinuity of diazolic-1,3 compounds to a structural variation, we have made a study of methyl-1 alkylthio (alkyl, benzyl)-2 imidazoles through mag-