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Dive into the research topics where Pascal Chanez is active.

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Featured researches published by Pascal Chanez.


Chest | 2012

Limited Short-term Steroid Responsiveness Is Associated With Thickening of Bronchial Basement Membrane in Severe Asthma

Arnaud Bourdin; Stephane Kleis; Mohamad Chakra; Isabelle Vachier; Fabrice Paganin; Philippe Godard; Pascal Chanez

BACKGROUND The clinical manifestations of bronchial remodeling in asthma and the potential impact of this process on lung function remain unclear. We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term. METHODS Sixty-three consecutive patients with severe asthma with chronic airflow impairment (post-bronchodilator FEV(1) < 80% predicted values) were recruited, clinically characterized, and had an initial bronchoscopy where endobronchial biopsy and BAL were performed. BAL cellular content was reported and reticular basement membrane (RBM) thickness was measured by validated repeated measures. Patients were then treated with 1 mg/kg/d of methyl prednisone, directly administered IV, for 10 days. A threshold of 15% FEV(1) improvement was used to discriminate responsive (group 1) and refractory patients (group 2). RESULTS Thirty-eight patients had a steroid responsiveness > 15% (group 1) and a thinner RBM at the biopsy level (5.78 ± 2.0 μm vs 7.60 ± 2.2 μm; P = .001) compared with nonsteroid responsive group 2 patients as defined. The best predictors for being unresponsive were no long-term treatment with oral steroids and increased RBM thickness. The associated receiver operating characteristic curve indicated that RBM thickness could predict steroid responsiveness below 15% with an area under the curve of 0.747 (P = .0002) at a threshold of 7 μm. CONCLUSIONS Features of airway remodeling are associated with limited short-term steroid responsiveness in severe asthma.


Revue Des Maladies Respiratoires | 2009

L'asthme: une maladie de tout l'arbre aerien.

I. Tillie-Leblond; Renaud Louis; A. Magnan; Marc Humbert; J. de Blic; Pascal Chanez

Inflammation and remodelling are constant features of asthma. They are present throughout the whole bronchial tree, even in the small airways (less than 2 mm). The inflammatory cell infiltrate and structural changes are, in most cases, identical. However, in severe asthma, nocturnal asthma and fatal asthma, the cellular infiltrate in the distal airways is more intense and the number of activated cells is increased. In fatal asthma there are major alterations in the distal airways involving the smooth muscle and the bronchial epithelium, and mucus hypersecretion leading to distal airway plugging. Thus the histopathological changes in the distal airways contribute to the most severe stages of asthma and should be targeted by treatment. Currently the non-invasive tools that reflect inflammation are unable to assess these changes in the distal airways.


Archive | 2017

Asthma: treatment and prevention of pulmonary exacerbations

Jérémy Charriot; Mathilde Volpato; Carey Sueh; Clément Boissin; Anne Sophie Gamez; Isabelle Vachier; Laurence Halimi; Pascal Chanez; Arnaud Bourdin


Les Cahiers Internationaux de Psychologie Sociale | 2009

L'appréciation psychosociale de l'observance dans l'asthme sévère : confrontation de données subjectives issues d'une consultation médicale à une mesure objective

Laurence Hamili; Gérard Pithon; René Pry; Muriel Varrin; Philippe Godard; Pascal Chanez


Archive | 2017

PROTOACCEPT1: Criteria Associated With Patient Willingness to Participate in Biomedical Research

Laurie Pahus; Laurence Halimi; Carey M Suehs; Isabelle Vachier; Grégory Marin; Nicolas Molinari; Dany Jaffuel; Jean Pierre Mallet; Pascal Chanez; Anne-Sophie Gamez


Archive | 2017

ComparisonbetweenBronchialand AlveolarSamplesof Bronchoalveolar LavageFluidin Asthma

Thierry Van Vyve; Pascal Chanez; Jean-Yves Lacoste; Jean Bousquet


Archive | 2017

Heterogeneity ofAirways Obstruction inAsthmatic Patients UsingHigh-Resolution ComputedTomography*

Fabrice Paganin; Jean MichelBruel; Pascal Chanez


Archive | 2015

epithelial cells to release eosinophil chemotactic activity Acetylcholine and substance P stimulate bronchial

Takateru Izumi; Etsuro Sato; Hiroshi Nomura; Sonoko Nagai; Robert Newton; Manminder Kaur; Malcolm Johnson; David P. Siderovski; Richard Leigh; Mark A. Giembycz; Neil S. Holden; Tresa George; Christopher F. Rider; Ambika Chandrasekhar; Suharsh Shah; W. Bunnett; Martin Steinhoff; Pierangelo Geppetti; Charalabos Pothoulakis; Stephanie Martinez; D. Charpin; Arnaud Bourdin; Pascal Chanez; Khuder Alagha; Alain Palot; Tunde Sofalvi; Laurie Pahus; Marion Gouitaa; Céline Tummino


/data/revues/09546111/v97i11/S0954611103002531/ | 2011

High levels of urinary leukotriene E 4 excretion in steroid treated patients with severe asthma

Isabelle Vachier; Maria Kumlin; Sven Erik Dahlén; Jean Bousquet; Philippe Godard; Pascal Chanez


/data/revues/00916749/v95i4/S0091674995701311/ | 2011

Detection of a novel macrophage-derived mucus secretagogue (MMS-68) in bronchoalveolar lavage fluid of patients with asthma

Kirk Sperber; Pascal Chanez; Jean Bousquet; Santindra Goswami; Zvi Marom

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Arnaud Bourdin

University of Montpellier

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Laurence Halimi

University of Montpellier

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Laurie Pahus

Aix-Marseille University

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Marc Humbert

Université Paris-Saclay

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Kirk Sperber

Icahn School of Medicine at Mount Sinai

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Zvi Marom

National Institutes of Health

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