Pascal Eric Zesiger

Benign partial epilepsy of childhood: a longitudinal neuropsychological and EEG study of cognitive function

The study combined prospective neuropsychological and EEG results of 22 children presenting with typical benign partial epilepsy with rolandic spikes (n=19) and occipital spikes (n=3). The aims were to assess the types of cognitive problems which may be encountered in this population, to evaluate the course of cognitive and learning capacities during the active phase of epilepsy, and to see if there was a correlation with paroxysmal activity on the EEG. Average age at entry in the study was 8.4 years and each child was seen two to four times over a period of 1 to 3 years. EEGs showed persistent spike foci in most cases that worsened in three cases, but there were no continuous spike‐waves during sleep. No child had persistent stagnation, marked fluctuations, or a regression in cognitive abilities. Of 22 children, 21 had average IQ (>80). Eight children had school difficulties requiring special adjustment. No single cognitive profile was identified. Four children had delayed language development and eight children had transient weak scores in one isolated domain (verbal, visuospatial, memory) which improved or normalized during the course of the study with concomitant EEG improvement or normalization. In two of the three children with aggravation of the paroxysmal EEG activity, clinical changes were documented. A proportion of children with typical benign partial epilepsy with rolandic spikes showed mild, varied, and transient cognitive difficulties during the course of their epilepsy, and in most cases this probably had a direct relation with the paroxysmal EEG activity.

Aspects of grammatical development in young French children with SLI

This paper presents an exploratory study of the spontaneous production of 11 French children clinically diagnosed as specific language impaired (SLI). In a cross-sectional study of the children under and over 5 years of age, we investigate the production of finite and non-finite verbal forms, of sentences with overt and null subjects, and of pronominal clitics. A comparison between younger and older children with SLI highlights developmental patterns which parallel normal syntactic development in important respects, though at a slower pace. An area of difficulty which clearly persists for the older group involves the domain of pronominal complement clitics.

Effects of lexicality and trigram frequency on handwriting production in children and adults

Recent studies of handwriting have shown that linguistic variables, such as phonology or lexicality, influence various aspects of the production of letter sequences. Following a previous experiment, in which a facilitation effect of words over pseudowords has been documented both in children and in adults, an experiment is reported concerning the effect of lexicality and of trigram frequency on handwriting production at different levels of handwriting mastery. In this experiment, 8- to 12-year-old children and adults were asked to write words, pseudowords ending with a frequent trigram, and pseudowords ending with a nonfrequent trigram. Results show that in adults there is a facilitation effect of words over pseudowords and of frequent trigrams over nonfrequent trigrams. In children, no clear effect of lexicality or trigram frequency could be observed. Developmental trends show that major changes in childrens handwriting occur between 8 and 10 years, whereas only minor modifications are observed between 10 and 12 years.

Eye Gaze During Face Processing in Children and Adolescents With 22q11.2 Deletion Syndrome

OBJECTIVE The 22q11.2 deletion syndrome (22q11DS) is a neurogenetic syndrome with high risk for the development of psychiatric disorder. There is interest in identifying reliable markers for measuring and monitoring socio-emotional impairments in 22q11DS during development. The current study investigated eye gaze as a potential marker during a face-processing task in children and young adolescents with 22q11DS. METHOD Eye gaze and behavioral correlates were investigated in 26 subjects (aged 8 to 15 years) with 22q11DS during the Jane Task, which targets featural and configural face processing. Individuals with 22q11DS were compared with chronologically age-matched healthy controls and individuals with idiopathic developmental delay (DD). RESULTS Few differences in accuracy were observed between patients with 22q11DS and DD controls; however individuals with 22q11DS spent less time on the eyes and more time on the mouths than both comparison groups. IQ predicted time on the eyes in subjects with 22q11DS, and anxiety predicted time on the eyes in DD and 22q11DS subjects. CONCLUSIONS These results provide evidence for abnormal exploration of faces in the syndrome and suggest that time spent on the eyes may contribute to face processing difficulties and interact with anxiety levels to exacerbate socio-emotional dysfunction in affected individuals.

Nondeclarative learning in children with Specific Language Impairment: Predicting regularities in the visuomotor, phonological, and cognitive domains

Ullman (2004) suggested that Specific Language Impairment (SLI) results from a general procedural learning deficit. In order to test this hypothesis, we investigated children with SLI via procedural learning tasks exploring the verbal, motor, and cognitive domains. Results showed that compared with a Control Group, the children with SLI (a) were unable to learn a phonotactic learning task, (b) were able but less efficiently to learn a motor learning task and (c) succeeded in a cognitive learning task. Regarding the motor learning task (Serial Reaction Time Task), reaction times were longer and learning slower than in controls. The learning effect was not significant in children with an associated Developmental Coordination Disorder (DCD), and future studies should consider comorbid motor impairment in order to clarify whether impairments are related to the motor rather than the language disorder. Our results indicate that a phonotactic learning but not a cognitive procedural deficit underlies SLI, thus challenging Ullmans’ general procedural deficit hypothesis, like a few other recent studies.

The acquisition of pronouns by French children: A parallel study of production and comprehension

This study examines syntactic and morphological aspects of the production and comprehension of pronouns by 99 typically developing French-speaking children aged 3 years, 5 months to 6 years, 5 months. A fine structural analysis of subject, object, and reflexive clitics suggests that whereas the object clitic chain crosses the subject chain, the reflexive clitic chain is nested within it. We argue that this structural difference introduces differences in processing complexity, chain crossing being more complex than nesting. In support of this analysis, both production and comprehension experiments show that children have more difficulty with object than with reflexive clitics (with more omissions in production and more erroneous judgments in sentences involving Principle B in comprehension). Concerning the morphological aspect, French subject and object pronouns agree in gender with their referent. We report serious difficulties with pronoun gender both in production and comprehension in children around the age of 4 (with nearly 30% errors in production and chance level judgments in comprehension), which tend to disappear by age 6. The distribution of errors further suggests that the masculine gender is processed as the default value. These findings provide further insights into the relationship between comprehension and production in the acquisition process.

Normal and pathological development of subject–verb agreement in speech production: a study on French children

We report a study on the spoken production of subject–verb agreement in number by four age groups of normally developing children (between 5 and 8;5) and a group of 8 children with Specific Language Impairment (SLI; between 5;4 and 9;4), all French speaking. The production of verb agreement was experimentally elicited by asking children to complete sentence preambles containing a head noun and a potentially attracting ‘local noun’. In contrast to previous studies that focused on attraction with local nouns within the subject constituent (postmodifiers), we also studied attraction with local nouns in structures that are not part of the subject constituent (interpolated adjuncts). In normally developing children, we report that (1) attraction effects appear from early on; (2) singular is produced as the default number until age 7 included; (3) more errors are produced with adjunct structures than with postmodifiers, but only from age 8;5 on. In contrast, even the older SLI children showed no attraction effect, a predominance of the singular as default, no effect of syntactic structure and, more generally, persistent high error rates. The turning point observed between 7 and 8;5 in normal children, characterized by a reduced error rate and a significant effect of syntactic structure, is interpreted as an index of the automatization of agreement. The syntactic structure effect is discussed in terms of the interplay of structural and working memory factors in the computation of long-distance relationships.

Writing without Graphic Motor Patterns: A Case of Dysgraphia for Letters and Digits Sparing Shorthand Writing

This paper reports the case of a patient HP who presents a dysgraphia affecting the production of letters and digits while sparing shorthand writing. HPs writing impairmentis two-fold. On one hand, HP produces systematic lettersubstitutions affecting exclusively lower-case letters b, p, d, and q. Such confusions are also observed in tasks assessing the mental imagery of letters and the processing of visually presented, isolated letters. This deficit is attributed to a circumscribed disruption of allographic representations. On the other hand, HP can write correctly formed letters and digits but the production of these symbols is slow and nonfluent. This disturbance was investigated by using a digitising tablet to record movements performed in grapho-motor production. The results of the analysis of temporal and kinematic indices suggest that graphic motor patterns of letters and digits are no longer available to this patient, whereas motor patterns underlying the production of shorthand seem unaffected. I...

The effects of bilingual growth on toddlers’ executive function

The mastery of two languages provides bilingual speakers with cognitive benefits over monolinguals, particularly on cognitive flexibility and selective attention. However, extant research is limited to comparisons between monolinguals and bilinguals at a single point in time. This study investigated whether growth in bilingual proficiency, as shown by an increased number of translation equivalents (TEs) over a 7-month period, improves executive function. We hypothesized that bilingual toddlers with a larger increase of TEs would have more practice in switching across lexical systems, boosting executive function abilities. Expressive vocabulary and TEs were assessed at 24 and 31 months of age. A battery of tasks, including conflict, delay, and working memory tasks, was administered at 31 months. As expected, we observed a task-specific advantage in inhibitory control in bilinguals. More important, within the bilingual group, larger increases in the number of TEs predicted better performance on conflict tasks but not on delay tasks. This unique longitudinal design confirms the relation between executive function and early bilingualism.

Preserved visual function in a case of occipitoparietal microgyria

A 20‐year‐old man with bilateral parasagittal occipitoparietal polymicrogyria and epilepsy, from whom normal functional magnetic resonance imaging and electroencephalogram responses to visual stimuli were obtained, was found to have no visual perceptual deficits. This suggests that microgyric cortex can perform normal visual functions, despite its gross structural abnormalities.