Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Pascal Gosselin is active.

Publication


Featured researches published by Pascal Gosselin.


Tetrahedron Letters | 1980

Dimerization of α-ethylenic dithioesters

Pascal Gosselin; Serge Masson; A. Thuillier

Abstract Methyl propenedithioate and three methyl 2-butenedithioates were prepared and all but one of these hetero-dienes gave dimers resulting from a [4 + 2] cycloaddition. Formation of a 1,5-dithiocin ring was also observed from the propenedithioate.


International Journal of Environmental Analytical Chemistry | 2000

Inclusion of Organic Pollutants in Cyclodextrins and Derivatives

Cecile Baudin; Christophe Péan; Bruno Perly; Pascal Gosselin

Abstract Both (−)-geosmin and (+)-2-methyl-isoborneol are the main compounds responsible for the unpleas-and smells found in the vicinity of water-processing plant. Attempts to eliminate them using oxidation, filtration and/or biologic degradation processes are only partly efficient. The use of cage molecules could provide an alternative solution. In this respect, cyclodextrins and derivatives have demonstrated their role as candidates as hosts for these highly hydrophobic compounds. In this paper, we evidence the complexation of above mentionned pollutants by cyclodextrins using high-resolution proton Nuclear Magnetic Resonance spectroscopy. The latter method is also used to afford a three-dimensional structure of inclusion complexes in solution and to show that cyclodextrins can as well discriminate between the optical isomers of synthetic geosmin and methyl-isoborneol. Finally, a solution to the problem of waste waters is proposed.


Tetrahedron-asymmetry | 1993

An easy synthesis of chiral sulfinyl allylic bromides and their use in the preparation of(R)S- and (S)S-2-p-tolylsulfinyl-1,3-alkadienes

Eric Bonfand; Pascal Gosselin; Christian Maignan

Abstract Condensation of (R)-vinyl-p-tolylsulfoxide anion on carbonyl compounds led directly to chiral allylic sulfinylalcohols 1 . By treatment with NBS/Me 2 S, these alcohols 1 were converted into the rearranged primary allylic bromides 2 via SN 2 ′ displacement. Optically pure (R)- and (S)-2-p-tolylsulfinyl-1,3-alkadienes 3 resulted from the action of KOH/ROH upon these bromides 2 via E 2 ′ eliminations.


Tetrahedron-asymmetry | 1994

Asymmetric intermolecular Diels-Alder reactions of enantiopure sulfinyl-homo- and -hetero-dienes : preliminary results

Pascal Gosselin; Eric Bonfand; Patricia Hayes; Richard Retoux; Christian Maignan

Abstract Reaction of (E)-(+)-(R)-2-p-tolylsulfinyl-1,3-pentadiene 1 with maleimide afforded 3 as a single, enantiomerically pure adduct under very mild conditions. 3 resulted from exclusive endo approach by a completely diastereofacialselective route. On the other hand, heterodiene (+)-(S)-3-p-tolylsulfinyl-3-buten-2-one 2 smoothly reacted with sensitive 2-methylenetetrahydrofuran yielding 1:1 diastereomeric dioxaspiroadducts 4a and 4b, readily separated by liquid chromatography.


Tetrahedron Letters | 1992

First syntheses of chiral 2-sulfinylbutadienes

Eric Bonfand; Pascal Gosselin; Christian Maignan

Abstract The title compounds were readily prepared respectively from (S)-3-p-tolylsulfinylbut-3-en-2-ol 3 and (S)-3-p-tolylsulfinylbut-3-en-2-one 4.


Tetrahedron Letters | 1989

Synthesis of earthy-mouldy smelling compounds-I stereoselective synthesis of (±)-geosmin

Pascal Gosselin; D. Joulain; P. Laurin; Francis Rouessac

Abstract The strongly earthy-smelling compound (±)-geosmin 1 is obtained stereospecifically in four steps and 42% overall yield from 1,4aβ-Dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one 2 . The key step involves a one-pot double-reduction of an epoxytosylate.


Tetrahedron Letters | 1983

Polycyclisations cationiques de polyenes via leurs bromohydrines - II synthese de la (±) aplysistatine

Pascal Gosselin; Francis Rouessac

Resume A synthesis of (±) aplysistatin 1 from geraniol is described in which the key step is the electrophilic cyclization of the bromohydrin 8 .


Tetrahedron Letters | 1986

Nouvelle application de la reaction des organomagnesiens sur les dithioesters : Synthese de la gamma-damascone

Pascal Gosselin

Resume A new synthetic route to γ-damasoone 1 starting from methyl-γ-dithiocyclogeranate 2 is described. Addition of HMPT is found necessary to perform the reaction of allyllmagnesium bromide with dithioester 2 . A new, very mild hydrolysis method is developped in order to transform the resulting vinylsulfide 4 into 1 .


Tetrahedron Letters | 1982

Synthese et cyclisation electrophile de la bromhydrine de l'acide homogeranique

Pascal Gosselin; Francis Rouessac

Abstract A new synthesis of 5-bromohexahydro-4,4,7a-trimethyl-2( 3H )-Benzofuranone (3aα,5β,7aβ)( 1 ) was achieved by electrophilic cyclization of the bromohydrin issued from pure homogeranic acid.


Tetrahedron-asymmetry | 2001

First synthesis of (−)-(1R,4R)- and (+)-(1S,4S)-(7,7-dimethyl-2-methylene-bicyclo[2.2.1]hept-1-yl)-methanol: new fenchone-derived chiral auxiliaries

Pascal Gosselin; Martine Lelievre; Benedicte Poissonnier

Abstract The treatment of (+)- or (−)-fenchones epoxides with 1:2 85% H 3 PO 4 :DMSO for 30 min at 20°C induced an enantiospecific Wagner–Meerwein rearrangement affording new C(10)- O -substituted camphor derivatives which could prove useful as chiral auxiliaries.

Collaboration


Dive into the Pascal Gosselin's collaboration.

Top Co-Authors

Avatar

Catherine Gaulon-Nourry

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Gilles Dujardin

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Francis Rouessac

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Christian Maignan

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Eric Bonfand

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Frédéric Legros

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge