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Pasha Khan

Scripps Research Institute

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Publication

Featured researches published by Pasha Khan.

Bioorganic & Medicinal Chemistry Letters | 2013

Small molecule amides as potent ROR-γ selective modulators

Pasha Khan; Bahaa El-Dien M. El-Gendy; Naresh Kumar; Ruben D. Garcia-Ordonez; Li Lin; Claudia Ruiz; Michael D. Cameron; Patrick R. Griffin; Theodore M. Kamenecka

The structure-activity relationship study of a diphenylpropanamide series of ROR-γ selective modulators is reported. Compounds were screened using chimeric receptor Gal4 DNA-binding domain (DBD)-NR ligand binding domain cotransfection assay in a two-step format. Three different regions of the scaffold were modified to assess the effects on repression of ROR-γ transcriptional activity and potency. The lead compound 1 exhibits modest mouse pharmacokinetics and an acceptable in vitro profile which makes it a suitable in vivo probe to interrogate the functions of ROR-γ in animal models of disease.

Bioorganic & Medicinal Chemistry Letters | 2014

Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors.

Zhuang Jin; Pasha Khan; Youseung Shin; Jingyi Wang; Li Lin; Michael D. Cameron; Jon Lindstrom; Paul J. Kenny; Theodore M. Kamenecka

Archive | 2013

Table 1A, ML124 & ML125 PubChem Assays (RORα Selective IAG & Dual RORα/γ IAG Probes)

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Figure 2, Stability of ML310

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Table 2, A summary of probe solubility, stability and GSH reactivity results

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Figure 4, Modulation of endogenous IL 17 and IL-23R by new RORγ inverse agonist probe (CID 51035449; ML310/SR2211) in EL-4 cells

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Figure 1, Probe chemical structure

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Table 1C, ML310 PubChem Assays (Selective RORγ IAG Probe)

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Figure 5, ML310/SR2211 modulates full length RORγ in reporter assays

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

Archive | 2013

Table 1B, ML176 PubChem Assays (RORα Selective IAG Probe)

Naresh Kumar; Theodore M. Kamenecka; Brent Lyda; Pasha Khan; Mi Ra Chang; Ruben D. Garcia-Ordonez; Michael D. Cameron; Jill Ferguson; Becky A. Mercer; Peter Hodder; Hugh Rosen; Patrick R. Griffin

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Collaboration

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Michael D. Cameron

Scripps Research Institute

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Theodore M. Kamenecka

Scripps Health

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Naresh Kumar

Scripps Research Institute

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Patrick R. Griffin

Scripps Research Institute

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Ruben D. Garcia-Ordonez

Scripps Research Institute

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Becky A. Mercer

Columbia University

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Brent Lyda

Scripps Research Institute

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Hugh Rosen

California Institute of Technology

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Jill Ferguson

Scripps Research Institute

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Mi Ra Chang

Scripps Research Institute

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