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Dive into the research topics where Pasquale Madonna is active.

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Featured researches published by Pasquale Madonna.


Stroke | 1998

Homozygous C677T Mutation of the 5,10 Methylenetetrahydrofolate Reductase Gene and Hyperhomocysteinemia in Italian Patients With a History of Early-Onset Ischemic Stroke

Lucia Soriente; Antonio Coppola; Pasquale Madonna; Anna Maria Cerbone; Giovanni Di Minno; Guiseppe Orefice; Armando D’Angelo

To the Editor: Case-control1 2 and prospective3 4 studies have suggested an association between moderate hyperhomocysteinemia and risk of ischemic stroke. Homozygosity for the C-to-T substitution at nucleotide 677 of the gene of 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with a 50% reduction of the activity of this enzyme5 and is the most common inherited cause of moderate hyperhomocysteinemia. In 1996 Klujitmans et al6 reported a threefold increase in the risk of early-onset cardiovascular disease in homozygotes for the C677T MTHFR mutation. However, the association of this genetic marker with arterial vascular events has been disputed by a nested case-control study.7 Markus et al8 recently failed to show an association between cerebrovascular disease and the MTHFR genotype, a comparable prevalence of homozygosity for the C677T MTHFR mutation being detectable in a population of 345 patients with ischemic stroke or transient ischemic attacks (TIA) and in 161 control subjects (10.7% versus 13.7%, respectively). Nor were nonfasting log homocysteine plasma levels able to identify subjects with a stroke history in that setting, as judged by the analysis of a subgroup of patients (n=160) and control subjects (n=75) in whom this amino acid was measured. However, as expected, the authors found a significant relationship between MTHFR genotype and homocysteine levels, the latter being also independently related to log serum folate. In the frame of a larger study on juvenile thrombotic events, we have evaluated a population of 60 consecutive patients with a history of early-onset ischemic stroke (29 females and 31 males, aged 5 to 64 years [mean age, 38; mean age at time of diagnosis, 34; range 4 to 49 years]) documented within 72 to 96 hours from the event by CT and/or MRI scans. Subjects who had suffered from TIA or who exhibited abnormalities of carotid …


European Journal of Internal Medicine | 2001

Severe pancytopenia and intrahepatic cholestasis in a patient with a history of Hodgkin’s disease.: Responsiveness to high-dose pulse steroid therapy and diagnosis of a late relapse

Antonio Coppola; Andrea Camera; Anna Pagano; Pasquale Madonna; Rosina Albisinni; L Pezzullo; Anna Maria Cerbone; Giovanni Di Minno

A 47-year-old male, treated 7 years earlier for Hodgkins disease (HD), was admitted with persistent fever, liver enlargement, and increased cholestasis parameters. He developed acute bone marrow failure and progressive worsening of his clinical condition and cholestasis markers without showing evidence of HD recurrence or second malignancy. High-dose intravenous pulse methylprednisolone therapy was given, after which resolution of pyrexia and progressive improvement in performance status and in hematological counts and cholestasis parameters were observed. During this phase, a bone biopsy showed HD marrow infiltration. This clinical course may reflect tumor cytokine-induced phenomena, significantly affected by high-dose steroids.


Stroke | 2002

Hyperhomocysteinemia and Other Inherited Prothrombotic Conditions in Young Adults With a History of Ischemic Stroke

Pasquale Madonna; Valentino De Stefano; Antonio Coppola; Ferdinando Cirillo; Anna Maria Cerbone; Giuseppe Orefice; Giovanni Di Minno


Circulation | 2001

Oxidative Stress and Platelet Activation in Homozygous Homocystinuria

Giovanni Davì; G. Di Minno; Antonio Coppola; Generoso Andria; Anna Maria Cerbone; Pasquale Madonna; Antonella Tufano; A. Falco; P. Marchesani; Giovanni Ciabattoni; C. Patrono


Stroke | 2000

G20210A PRTH Gene Mutation and Other Trombophilic Polymorphisms in Patients With Cerebral Vein Thrombosis

Pasquale Madonna; Valentino De Stefano; Antonio Coppola; Rosina Albisinni; Anna Maria Cerbone


Haematologica | 1997

Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency

Antonio Coppola; Rosina Albisinni; Pasquale Madonna; Anna Pagano; Anna Maria Cerbone; G. Di Minno


Thrombosis Research | 2000

Idiopathic Budd-Chiari syndrome in a patient with homozygous Factor V Leiden and heterozygous Factor II G20210A mutations.

Valentino De Stefano; Pasquale Madonna; Alessandro Giannino; Antonio Coppola; Anna Maria Cerbone; Paolo Pauciullo; Giovanni Di Minno


Thrombosis Research | 2001

Coexistence of Thrombophilic Gene Polymorphisms Among 559 Unrelated Consecutive Patients With a History of Thrombosis

Pasquale Madonna; Umberto Piemontino; Valentino DeStefano; Rosina Albisinni; Anna Maria Cerbone; Giovanni Di Minno


Archive | 2010

Response: Hyperhomocysteinemia, MTHFR 677C->T Polymorphism, and Stroke

Maria Rosaria Cerbone; Peter J. Kelly; M. Barron; Karen L. Furie; Pasquale Madonna; Antonio Coppola


Archive | 2010

Patients With Cerebral Vein Thrombosis G20210A PRTH Gene Mutation and Other Trombophilic Polymorphisms in

Anna Maria Cerbone; Pasquale Madonna; Valentino De Stefano; Antonio Coppola; Rosina Albisinni

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Anna Maria Cerbone

University of Naples Federico II

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Antonio Coppola

University of Naples Federico II

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Giovanni Di Minno

University of Naples Federico II

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Rosina Albisinni

University of Naples Federico II

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Anna Pagano

University of Naples Federico II

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Alessandro Giannino

University of Naples Federico II

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Andrea Camera

University of Naples Federico II

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Antonella Tufano

University of Naples Federico II

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Armando D’Angelo

Vita-Salute San Raffaele University

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