Patrícia Borba Martiny
Universidade Federal do Rio Grande do Sul
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Publication
Featured researches published by Patrícia Borba Martiny.
Reproductive Biology | 2017
Diego Duarte Alcoba; Júlia Schneider; Letícia Arruda; Patrícia Borba Martiny; Edison Capp; Helena von Eye Corleta; Ilma Simoni Brum
In vitro oocyte maturation presents many advantages and its success is related to the selection of fully grown oocytes. In animal models, staining of cumulus-oocyte complexes (COCs) with Brilliant Cresyl Blue (BCB) is widely used for this selection. However, a lack of information about the safety of BCB makes its applicability in humans questionable. Because granulosa and cumulus cells have a close relationship with the oocyte and taking into account that follicular cells are also exposed to BCB when this pre-selection method is applied, we aimed to evaluate the effects of BCB on human follicular cells exposed to BCB. Cytotoxicity tests (Sulforhodamine B and Neutral Red Uptake) and gene and protein expression of elements related to the cell cycle (BAX, BCL2, TP53 and CDKN1A), as well as to cell death and metabolism (GAPDH), glucose consumption, and estradiol and progesterone secretion, were examined in granulosa and cumulus cells with and without exposure to BCB. Regardless estradiol secretion and glucose consumption, all other evaluations presented similar results between control and treated (BCB) groups, independently of cell type. Therefore, our results demonstrate convincingly that BCB seems to be safe for use in humans and it should encourage future studies to evaluate the development of embryos derived from human oocytes selected by BCB staining.
Revista Da Sociedade Brasileira De Medicina Tropical | 2011
Patrícia Borba Martiny; Fernanda de-Paris; Alice Beatriz Mombach Pinheiro Machado; Ricardo Obalski de Mello; Martha Bergman Senger; Maria Clara Medina Corrêa; Luiz Carlos Werres Júnior; Carolina Fischinger Moura de Souza
INTRODUCTION Human cytomegalovirus (HCMV) is often reactive in latently infected immunosuppressed patients. Accordingly, HCMV remains one of the most common infections following solid organ and hemopoietic stem cell transplantations, resulting in significant morbidity, graft loss and occasional mortality. The early diagnosis of HCMV disease is important in immunosuppressed patients, since in these individuals, preemptive treatment is useful. The objective of this study was to compare the performance of the in-house qualitative polymerase chain reaction (PCR) and pp65 antigenemia to HCMV infection in immunosuppressed patients in the Hospital de Clínicas of Porto Alegre (HCPA). METHODS A total of 216 blood samples collected between August 2006 and January 2007 were investigated. RESULTS Among the samples analyzed, 81 (37.5%) were HCMV-positive by PCR, while 48 (22.2%) were positive for antigenemia. Considering antigenemia as the gold standard, sensitivity, specificity, positive predictive values and negative predictive values for PCR were 87.5%, 76.8%, 51.8% and 95.5% respectively. CONCLUSIONS These results demonstrated that qualitative PCR has high sensitivity and negative predictive value (NPV). Consequently PCR is especially indicated for the initial diagnosis of HCMV infection. In the case of preemptive treatment strategy, identification of patients at high-risk for HCMV disease is fundamental and PCR can be useful tool.
Journal of Applied Biomedicine | 2018
Patrícia Borba Martiny; Diego Duarte Alcoba; Brasil Silva Neto; Paulo C. Carvalho; Ilma Simoni Brum
Archive | 2014
Maria Eduarda Azambuja Amaral; Ana Caroline Hillebrand; Patrícia Borba Martiny; Brasil Silva Neto; Ilma Simoni Brum
Archive | 2014
Ana Caroline Hillebrand; Maria Eduarda Azambuja Amaral; Caetana Machado Ledur; Patrícia Borba Martiny; Milton Berger; Brasil Silva Neto; Ilma Simoni Brum
Archive | 2014
Caetana Machado Ledur; Ana Caroline Hillebrand; Patrícia Borba Martiny; Brasil Silva Neto; Milton Berger; Ilma Simoni Brum
Archive | 2013
Maria Eduarda Azambuja Amaral; Patrícia Borba Martiny; Gisele Branchini; Brasil Silva Neto; Milton Berger; Ilma Simoni Brum
Clinical & Biomedical Research | 2013
Patrícia Borba Martiny; Maria Eduarda Azambuja Amaral; Gustavo Dias Ferreira; Ana Caroline Hillebrand; Gisele Branchini; Brasil Silva Neto; Vanderlei Biolchi; Ilma Simoni Brum da Silva
Rev. HCPA & Fac. Med. Univ. Fed. Rio Gd. do Sul | 2008
Ricardo Obalski de Mello; Patrícia Borba Martiny; Juliana Belo Saturi; Fernanda de Paris; Alice Beatriz Mombach Pinheiro Machado; Martha Bergman Senger; Maria Clara Medina Corrêa; Luiz Carlos Werres Júnior; Graziela Turra; Carolina Fischinger Moura de Souza
Clinical & Biomedical Research | 2008
Ricardo Obalski de Mello; Patrícia Borba Martiny; Juliana Belo Saturi; Fernanda de Paris; Alice Beatriz Pinheiro Machado; Martha Bergman Senger; Maria Clara Medina Corrêa; Luiz Carlos Werres Júnior; Graziela Turra; Carolina Fischinger Moura de Souza
Collaboration
Dive into the Patrícia Borba Martiny's collaboration.
Carolina Fischinger Moura de Souza
Universidade Federal do Rio Grande do Sul
View shared research outputsAlice Beatriz Mombach Pinheiro Machado
Universidade Federal do Rio Grande do Sul
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