Patricia Owen
Medical Research Council
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Featured researches published by Patricia Owen.
The Lancet | 1971
L. H. Opie; Michael Thomas; Patricia Owen; R.M. Norris; A.J. Holland; S. van Noorden
Abstract The hypothesis that high circulating free-fatty-acid (F.F.A.) concentrations may be arrhythmogenic to the ischaemic myocardium has important implications for the treatment of patients with acute myocardial infarction. Direct evidence for this hypothesis has been obtained by other workers using the ischaemic dog-heart preparation. The possible arrhythmogenic effect of high plasma-F.F.A. concentrations has now been re-examined in experimental occlusion of the anterior descending coronary artery (or one of its branches) in 30 dogs. In no case was it clear that high plasma-F.F.A. concentrations by themselves provoked or exaggerated ectopic activity, even though the site and size of arterial ligations, multiple ligations, and adrenaline infusion were designed to lead to arrhythmias. However, when combined with adrenaline infusion, elevation of plasma-F.F.A. concentrations provoked ectopic activity in 3 of 4 dogs. Of all 30 dogs, ventricular tachycardia occurred in only 2 and ventricular fibrillation in another 2. These results argue against a major role for high plasma-F.F.A. concentrations in the genesis of serious arrhythmias after coronary-artery occlusion.
American Journal of Cardiology | 1970
Patricia Owen; Michael Thomas; Val Young; L. H. Opie
Abstract A technique for the study of local metabolic changes in coronary venous blood draining from a small area of ischemic myocardium is described. Overt left ventricular failure, ventricular arrhythmias and possible secondary effects on local metabolic changes were avoided. Metabolic changes in local coronary venous blood and in coronary sinus blood were compared. Gross changes detected by local coronary venous sampling were not observed in coronary sinus blood samples. The possible relevance of this observation to clinical studies was noted. The small ischemic lesion usually involved less than 10 percent of the heart volume and was characterized by acute S-T segment elevation in the epicardial electrocardiogram and by positive changes in values for local coronary venous blood lactate, pyruvate, lactate/ pyruvate ratio, glucose, potassium and phosphate. Free fatty acids and beta hydroxybutyrate and acetoacetate levels were also studied. The technique and its results are compared with other methods of study of the metabolism of ischemic heart tissue.
The Lancet | 1969
Patricia Owen; Michael Thomas; L. H. Opie
Abstract Because the survival of ischaemic heart-tissue may be influenced by the relative utilisation of glucose and free fatty acids (F.F.A.), experiments were designed to compare the handling of these substrates by ischaemic and non-ischaemic myocardium in identical experimental circumstances. The arteriovenous difference of glucose across the ischaemic zone increased, while that of F.F.A. was unchanged. This implies increasing emphasis on the utilisation of glucose, relative to that of F.F.A., by the ischaemic heart-tissue. The observations may be relevant to the role of glucose in the treatment of patients with acute myocardial infarction.
American Journal of Cardiology | 2000
Kenneth A. LaBresh; Patricia Owen; Catherine Alteri; Susan Reilly; Patricia Shea Albright; Andrew R Hordes; Peter A Shaftel; Thomas E Noonan; Cheryl A. Stoukides; Alan F Kaul
The American Heart Association (AHA) Consensus Panel Statement for Preventing Heart Attack and Death in Patients with Coronary Disease provides recommendations for the secondary prevention of heart disease in at-risk patients. Blackstone Cardiology Associates of Pawtucket, Rhode Island, undertook an initiative in their practice implementing secondary-prevention guidelines in patients with coronary artery disease. This retrospective study evaluates practice patterns for the management of hyperlipidemia for a cardiology group in an ambulatory and hospital setting after the institution of a physician-supervised, nurse-based disease management program. Practice patterns in patients with established coronary heart disease treated in a lipid center compared with non-lipid-center settings were evaluated. Parameters evaluated included documenting low-density lipoprotein (LDL) cholesterol, presence of lipid-lowering therapy, and achieving the National Cholesterol Education Program II (NCEP II) goal of LDL-cholesterol levels < or =100 mg/dL in patients with preexisting coronary artery disease. A total of 352 patients met inclusion criteria in the lipid-center setting and were compared with 289 non-lipid-center consecutively chosen patients. Age and gender differences were also evaluated. Inpatient medical records from a 254-bed Brown University-affiliated teaching hospital were also evaluated for lipid profile, achievement of NCEP II goal, and use of lipid-lowering medication on admission and discharge. The most recent LDL-cholesterol values of patients followed in the lipid-center and in the non-lipid-center setting of the Blackstone Cardiology Associates were compared. Blackstone Cardiology Associates consists of 4 cardiologists and 4 advanced-practice nurses. Achievement of LDL-cholesterol goal was higher in both the lipid-center and non-lipid-center settings compared with baseline. A smaller percentage of patients at goal in the lipid setting is likely due to referral bias resulting in patients with more difficult-to-manage mixed dyslipidemias and behavior-management issues ending up in the lipid center. There were no apparent sex differences at goal, and more elderly (age > or =65 years) achieved goal in the lipid clinic center. In the non-lipid-center setting, more males were at goal and had a lower mean LDL-cholesterol level.
Biochemical Journal | 1971
L. H. Opie; K. R. L. Mansford; Patricia Owen
The Journal of Thoracic and Cardiovascular Surgery | 1989
Schubert T; Vetter H; Patricia Owen; B. Reichart; Lionel H. Opie
The Journal of Thoracic and Cardiovascular Surgery | 1993
Patricia Owen; du Toit Ef; Lionel H. Opie
The Journal of Thoracic and Cardiovascular Surgery | 1991
von Oppell Uo; Linda M. King; du Toit Ef; Patricia Owen; B. Reichart; Lionel H. Opie
The Journal of Thoracic and Cardiovascular Surgery | 1991
U. von Oppell; E.F. Du Toit; Linda M. King; Patricia Owen; Tim Dunne; B. Reichart; Lionel H. Opie
International symposium on organ precurement and preservation. 4 | 1990
Dieter Boehm; Paul Human; H. Reichenspurner; U. Von Oppell; Patricia Owen; Lionel H. Opie; B. Reichart