Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Patrícia Weidlich is active.

Publication


Featured researches published by Patrícia Weidlich.


Brazilian Oral Research | 2008

Association between periodontal diseases and systemic diseases

Patrícia Weidlich; Renata Cimões; Cláudio Mendes Pannuti; Rui Vicente Oppermann

Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Brazilians (3 concerning cardiovascular disease, 7 about pregnancy outcomes, 9 about diabetes and one regarding pneumonia). Although the majority of them observed an association between periodontitis and systemic conditions, a causal relationship still needs to be demonstrated. Further studies, particularly interventional well-designed investigations, with larger sample sizes, need to be conducted in Brazilian populations.


Brazilian Oral Research | 2012

Periodontal disease and systemic complications.

Rui Vicente Oppermann; Patrícia Weidlich; Marta Liliana Musskopf

Periodontal diseases comprise a number of infectious and inflammatory conditions brought about by the interaction between supragingival and subgingival biofilms and the host inflammatory response. Periodontal diseases should be considered systemic conditions. This means that they are both modulated by the bodys systems and play a role as a risk factor for systemic derangements. The current evidence supports some of these interactions, such as smoking as a risk factor for periodontal disease and diabetes mellitus, as both influenced by and influencing inflammatory changes in the periodontal tissue. Other potential associations are still being researched, such as obesity, hormonal changes, cardiovascular disease, and adverse outcomes in pregnancy. These, and others, still require further investigation before the repercussions of periodontal disease can be fully elucidated. Nevertheless, at the present time, the treatment of periodontal diseases-and, most importantly, their prevention-enables adequate intervention as a means of ensuring periodontal health.


Journal of Periodontal Research | 2013

Effect of nonsurgical periodontal therapy on serum and gingival crevicular fluid cytokine levels during pregnancy and postpartum

Tiago Fiorini; Cristiano Susin; J. M. da Rocha; Patrícia Weidlich; Priscila Vianna; Carlos Heitor Cunha Moreira; J. A. Bogo Chies; Cassiano Kuchenbecker Rösing; Rui Vicente Oppermann

BACKGROUND AND OBJECTIVE A low-grade systemic inflammatory status originating from periodontal infection has been proposed to explain the association between periodontal disease and systemic conditions, including adverse obstetric outcomes. The aim of this study was to evaluate the effect of periodontal therapy during pregnancy on the gingival crevicular fluid and serum levels of six cytokines associated with periodontal disease and preterm birth. MATERIAL AND METHODS A subsample of 60 women (18-35 years of age) up to 20 gestational weeks, previously enrolled in a larger randomized clinical trial, was recruited for the present study. Participants were randomly allocated to receive either comprehensive nonsurgical periodontal therapy before 24 gestational weeks (n = 30, test group) or only one appointment for supragingival calculus removal (n = 30, control group). Clinical data, and samples of blood and gingival crevicular fluid, were collected at baseline, at 26-28 gestational weeks and 30 d after delivery. The levels of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70 and tumor necrosis factor-α were analyzed by flow cytometry. RESULTS After treatment, a major reduction in periodontal inflammation was observed in the test group, with bleeding on probing decreasing from 49.62% of sites to 11.66% of sites (p < 0.001). Periodontal therapy significantly reduced the levels of IL-1β and IL-8 in gingival crevicular fluid (p < 0.001). However, no significant effect of therapy was observed on serum cytokine levels. After delivery, the levels of IL-1β in the gingival crevicular fluid of the test group were significantly lower than were those in the control group (p < 0.001), but there were no significant differences between test and control groups regarding serum cytokine levels. CONCLUSION Although periodontal therapy during pregnancy successfully reduced periodontal inflammation and gingival crevicular fluid cytokine levels, it did not have a significant impact on serum biomarkers.


Cytokine | 2012

Relationship between cytokine levels in serum and gingival crevicular fluid (GCF) in pregnant women

Tiago Fiorini; Priscila Vianna; Patrícia Weidlich; Marta Liliana Musskopf; Carlos Heitor Cunha Moreira; José Artur Bogo Chies; Cassiano Kuchenbecker Rösing; Rui Vicente Oppermann; Cristiano Susin

BACKGROUND Periodontal disease has been linked to systemic diseases/disorders and a low-grade systemic inflammatory status originated from periodontitis has been proposed as a possible explanation for this association. This study evaluates the relationship, early in pregnancy, between gingival crevicular fluid (GCF) and serum levels of a panel of cytokines that have been implicated in PTB and periodontal disease. METHODS One hundred pregnant women aged 18-35 years old with a gestational age up to 20 weeks were included (mean±SD gestational age:16.1±3.5 weeks). Four periodontal sites per subject were randomly selected for GCF collection. Serum and GCF levels of IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α were analyzed using a cytometric bead array. Regression and correlation analyses were used to assess the relationship between serum and GCF cytokine levels. RESULTS Participants had widespread periodontal inflammation but limited periodontal destruction. Cytokine levels were significantly higher in GCF than serum for all cytokines but IL-10. GCF levels had small but significant effect on serum levels for IL-10 (β=0.34±0.09, p<0.01), IL-12p70 (β=0.48±0.08, p<0.01) and TNF-α (β=0.29±0.09, p<0.01). Periodontal probing depth and bleeding on probing were significantly associated with GCF levels for IL-1β, IL-6 and IL-8; however, they had negligible effect on serum cytokine levels. Correlation between GCF and serum levels was non-significant, except for IL-12p70, which showed a significant but small correlation between the two sources (r=0.32, p=0.001). CONCLUSIONS GCF cytokine levels were not strongly associated with serum cytokine levels in pregnant women with widespread periodontal inflammation but limited periodontal destruction.


American Journal of Orthodontics and Dentofacial Orthopedics | 2015

Association among pain, masticatory performance, and proinflammatory cytokines in crevicular fluid during orthodontic treatment

Gustavo Hauber Gameiro; Christian Schultz; Marcos Porto Trein; Karina Santos Mundstock; Patrícia Weidlich; Jeferson Ferraz Goularte

INTRODUCTION Orthodontic patients usually complain about masticatory limitations associated with the activation of fixed appliances. The aim of this investigation was to evaluate whether orthodontic pain reflects differences in the objective evaluation of mastication and in the levels of proinflammatory cytokines in the crevicular fluid of patients undergoing orthodontic treatment. METHODS Twenty patients with malocclusions requiring orthodontic treatment were included in this prospective study. Their pain experience, masticatory performance, and levels of interleukin 1-beta and prostaglandin E2 in crevicular fluid were evaluated at 3 times: before bracket placement, 24 hours after archwire placement, and 30 days after the initial appointment. All variables were compared with those of a control group of 25 subjects with normal occlusion. RESULTS The masticatory performance of the patients was significantly reduced at 24 hours after bracket placement, the period in which they reported higher values of pain and had higher levels of interleukin 1-beta. The levels of prostaglandin E2 did not change in the periods evaluated, and there were no correlations between the levels of cytokines and the functional limitations observed. The only significant correlation was between pain and decreased masticatory performance. CONCLUSIONS The masticatory performance of orthodontic patients is significantly reduced only during the period of greatest pain. However, these alterations did not correlate with any measurement of interleukin 1-beta or prostaglandin E2 in the crevicular fluid, suggesting that these solitary measurements are inadequate to predict the temporary pain and masticatory limitations experienced by patients undergoing orthodontic treatment.


Brazilian Oral Research | 2015

Efficacy of a triclosan formula in controlling early subgingival biofilm formation: a randomized trial

Ernesto Andrade; Patrícia Weidlich; Patrícia Daniela Melchiors Angst; Sabrina Carvalho Gomes; Rui Vicente Oppermann

The aim of this study was to determine the efficacy of rinses with slurries of a dentifrice containing triclosan (TCS), as compared with rinses with slurries from a control dentifrice, in controlling early subgingival biofilm formation. A double-blind, randomized and cross-over clinical trial was designed, and 26 dental students were included. In the first period, participants were randomized to rinse with a TCS slurry or a control slurry, in a 12 h interval, and to refrain from mechanical cleaning. A Plaque Free Zone Index was assessed at 24 h, 48 h, 72 h and 96 h. After a washout period of 10 days, the second experimental period was conducted, following the same protocol as the first period, except that the slurry groups were switched. Use of the TCS slurry resulted in a significantly higher percentage of plaque-free surfaces, both at 24 h and at 72 h (p < 0.01). In the of 48-72 h interval, the triclosan slurry showed a lower percentage of sites converted to a score of 2 (38.1% for the test versus 40% for the control product, p = 0.015). In conclusion, rinsing with slurries of dentifrice containing TCS retards the down growth of bacterial biofilms from the supra- to the subgingival environment.


Clinical Oral Investigations | 2014

Response to a letter to the editor addressing the publication "Effect of nonsurgical periodontal therapy and strict plaque control on preterm/low birth weight: a randomized controlled clinical trial".

Patrícia Weidlich; Carlos Heitor Cunha Moreira; Tiago Fiorini; Marta Liliana Musskopf; José Mariano da Rocha; Maria Lúcia Rocha Oppermann; Anne Merete Aass; Per Gjermo; Cristiano Susin; Cassiano Kuchenbecker Rösing; Rui Vicente Oppermann

1. The traditional classification based on a distinction between “spontaneous” and “medically indicated” preterm birth proposed by Dr. Lopez has long been debated in obstetrics due to its inherent ambiguity and it is no longer in use. To properly address this issue, the Global Alliance to Prevent Prematurity and Stillbirth task force established a new classification system for the preterm birth syndrome intended for clinical and research use [1]. The 2009 classification was based on the following five components: (1) maternal conditions prior to presentation for birth, (2) fetal conditions prior to presentation for birth, (3) placental pathologies, (4) signs of early labor, and (5) route (pathway) of birth (started spontaneously or by the doctor). Notably, risk factors or the route of delivery (vaginal or cesarean) are explicitly omitted in this new classification [2]. Whereas our original publication did not report results according to the above-mentioned classification, data collected during the study were retrieved and the results are presented below for the reader’s sake. As reported previously, 14 and 17 preterm births occurred in the control and test groups, respectively. Four out of the 14 preterm births in the control group had significant maternal conditions as defined by the new classification, namely one case of chronic hypertension, one case of preeclampsia, and two cases of urinary tract infection. The remaining ten women had no maternal, fetal, or placental factors for preterm birth that could be identified. In the test group, 6 out of the 17 preterm births showed significant pathological conditions: one case of preeclampsia, one case of depressed mood, two cases of gestational diabetes, and two cases of urinary tract infection. Eleven cases of preterm birth in the test group did not have any maternal, fetal, or placental factors that could be identified. No cases of fetal or placental pathological conditions were identified in any of the participants. Spontaneous delivery occurred in 10 out of 14 women in the control group and in 11 out of 17 women in the intervention group (71.4 vs. 64.7 %, p=0.70). Thus, no significant differences could be observed between groups when the most current classification system is used, corroborating our initial findings and conclusions. P. Weidlich (*) : T. Fiorini :M. L. Musskopf : J. M. da Rocha : M. L. R. Oppermann : C. K. Rösing : R. V. Oppermann Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil e-mail: [email protected]


Brazilian Oral Research | 2018

Association between metabolic syndrome and periodontitis: a systematic review and meta-analysis

Luciana Dondonis Daudt; Marta Liliana Musskopf; Marina Mendez; Luciana Reck Remonti; Cristiane Bauermann Leitão; Jorge Luiz Gross; Patrícia Weidlich; Rui Vicente Oppermann

The aim of the present study was to evaluate the association between metabolic syndrome (MS) and periodontitis (PD), through a systematic review and meta-analysis. Original observational studies assessing the association between MS and PD in adults, published before May 11th (2017), were identified through electronic searches of MEDLINE, EMBASE and Cochrane Library databases. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline was used. For studies to be included, they had to mention the criteria used to diagnose MS and to have used at least one clinical measure to diagnose PD. There was no language restriction. Three reviewers independently identified eligible studies for possible inclusion in the systematic review and meta-analysis. The quality of the studies was evaluated by the Newcastle-Ottawa scale for observational studies. A random model meta-analysis was conducted. The strategies used to investigate heterogeneity were sequential analysis, subgroup analysis, univariate meta-regression and sensitivity analysis. Thirty-three studies met the inclusion criteria for the systematic review, and 26 had enough information to be included in the meta-analysis, totaling 52,504 patients. MS and PD were associated with an odds ratio of 1.38 (95%CI 1.26-1.51; I2 = 92.7%; p < 0.001). Subgroup analysis showed that complete periodontal examination (I2 = 70.6%; p < 0.001) partially explained the variability between studies. The present findings suggest an association between MS and PD. Individuals with MS are 38% more likely to present PD than individuals without this condition. Prospective studies should be conducted to establish cause and effect relations between MS and PD.


Brazilian Oral Research | 2018

Oral health related quality of life among pregnant women: a randomized controlled trial.

Marta Liliana Musskopf; Fernanda Carpes Milanesi; José Sales Mariano da Rocha; Tiago Fiorini; Carlos Heitor Cunha Moreira; Cristiano Susin; Cassiano Kuchenbecker Rösing; Patrícia Weidlich; Rui Vicente Oppermann

The aim of the present study was to compare negative impacts of oral conditions in Oral Heath Related Quality of Life (OHRQoL) assessed by the Oral Health Impact Profile-14 (OHIP-14) scores in pregnant women receiving or not comprehensive periodontal treatment. This randomized controlled clinical trial included pregnant women aged between 18 and 35 years old. Participants were randomized in a test group with 96 and a control group with 114 women. Patients in the test group received comprehensive periodontal treatment, supra and subgingival scaling and root-planning and periodontal maintenance appointments. The OHIP-14 was applied before and after treatment. The primary outcome was changes in OHIP-14 scores after follow-up period. The impact of having received or not comprehensive periodontal treatment on the change of the OHIP-14 scores was also investigated. Both groups showed significant reduction in OHIP-14 scores and effect size for the test group was 0.60 and 0.36 for the control group. Multinomial logistic regression analysis showed that participants of the control group had 5.9-fold odds (CI 95% 1.88-18.52) of worsening in OHIP-14 scores and their perception of oral conditions in relation to test group. Comprehensive periodontal treatment during pregnancy can reduce the negative impacts in OHRQoL.


Clinical Oral Investigations | 2013

Effect of nonsurgical periodontal therapy and strict plaque control on preterm/low birth weight: a randomized controlled clinical trial

Patrícia Weidlich; Carlos Heitor Cunha Moreira; Tiago Fiorini; Marta Liliana Musskopf; José Mariano da Rocha; Maria Lúcia Rocha Oppermann; Anne Merete Aass; Per Gjermo; Cristiano Susin; Cassiano Kuchenbecker Rösing; Rui Vicente Oppermann

Collaboration


Dive into the Patrícia Weidlich's collaboration.

Top Co-Authors

Avatar

Rui Vicente Oppermann

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Marta Liliana Musskopf

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Cassiano Kuchenbecker Rösing

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Carlos Heitor Cunha Moreira

Universidade Federal de Santa Maria

View shared research outputs
Top Co-Authors

Avatar

Tiago Fiorini

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Luciana Dondonis Daudt

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

José Mariano da Rocha

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Cristiano Susin

Georgia Regents University

View shared research outputs
Top Co-Authors

Avatar

Fernando Gerchman

Universidade Federal do Rio Grande do Sul

View shared research outputs
Top Co-Authors

Avatar

Francisco Wilker Mustafa Gomes Muniz

Universidade Federal do Rio Grande do Sul

View shared research outputs
Researchain Logo
Decentralizing Knowledge