Patrick Karlsson
Uppsala University
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Publication
Featured researches published by Patrick Karlsson.
Experimental Physiology | 2009
Jing-Xia Liu; Anna-Stina Höglund; Patrick Karlsson; Joakim Lindblad; Rizwan Qaisar; Sudhakar Aare; Ewert Bengtsson; Lars Larsson
This comparative study of myonuclear domain (MND) size in mammalian species representing a 100 000‐fold difference in body mass, ranging from 25 g to 2500 kg, was undertaken to improve our understanding of myonuclear organization in skeletal muscle fibres. Myonuclear domain size was calculated from three‐dimensional reconstructions in a total of 235 single muscle fibre segments at a fixed sarcomere length. Irrespective of species, the largest MND size was observed in muscle fibres expressing fast myosin heavy chain (MyHC) isoforms, but in the two smallest mammalian species studied (mouse and rat), MND size was not larger in the fast‐twitch fibres expressing the IIA MyHC isofom than in the slow‐twitch type I fibres. In the larger mammals, the type I fibres always had the smallest average MND size, but contrary to mouse and rat muscles, type IIA fibres had lower mitochondrial enzyme activities than type I fibres. Myonuclear domain size was highly dependent on body mass in the two muscle fibre types expressed in all species, i.e. types I and IIA. Myonuclear domain size increased in muscle fibres expressing both the β/slow (type I; r= 0.84, P < 0.001) and the fast IIA MyHC isoform (r= 0.90; P < 0.001). Thus, MND size scales with body size and is highly dependent on muscle fibre type, independent of species. However, myosin isoform expression is not the sole protein determining MND size, and other protein systems, such as mitochondrial proteins, may be equally or more important determinants of MND size.
International Journal of Signal and Imaging Systems Engineering | 2008
Carolina Wählby; Patrick Karlsson; Sara Henriksson; Chatarina Larsson; Mats Nilsson; Ewert Bengtsson
Many modern molecular labelling techniques result in bright point signals. Signals from molecules that are detected directly inside a cell can be captured by fluorescence microscopy. Signals repres ...
international symposium on biomedical imaging | 2004
Patrick Karlsson; Joakim Lindblad
Archive | 2013
Jing-Xia Liu; Patrick Karlsson; Joakim Lindblad; Rizwan Qaisar; Sudhakar Aare; Ewert Bengtsson; Lars Larsson
Archive | 2008
Patrick Karlsson; Joakim Lindblad
XXXVIth European Muscle Conference of the European Society for Muscle Research : European Muscle Conference 2007 | 2007
Patrick Karlsson; Joakim Lindblad; Ewert Bengtsson; Anna-Stina Höglund; Jing-Xia Liu; Lars Larsson
Archive | 2007
Patrick Karlsson; Joakim Lindblad; Ewert Bengtsson; Anna-Stina Höglund; Jing-Xia Liu; Lars Larsson
Biophysical Journal : 637A-637A Suppl. S | 2007
Anna-Stina Höglund; Jing-Xia Liu; Patrick Karlsson; Joakim Lindblad; Gunilla Borgefors; Ewert Bengtsson; Lars Larsson
industrial conference on data mining | 2006
Carolina Wählby; Patrick Karlsson; Sara Henriksson; Chatarina Larsson; Mats Nilsson; Ewert Bengtsson
Archive | 2004
Johan Degerman; Karin Althoff; Thorleif Thorlin; Carolina Wählby; Patrick Karlsson; Ewert Bengtsson; Tomas Gustavsson