Paul A. Arbisi

An MMPI-2 infrequent response scale for use with psychopathological populations: The Infrequency-Psychopathology Scale, F(p) .

This article describes the development and initial validation of a new Minnesota Multiphasic Personality Inventory—2 (MMPI-2; J. N. Butcher, W. G. Dahlstrom, J. R. Graham, A. Tellegen, & B. Kaemmer, 1989) scale designed to detect infrequent responding in settings characterized by relatively high base rates of psychopathology and psychological distress. The Infrequency-Psychopathology Scale, F(p), was developed by identifying a set of 27 MMPI-2 items answered infrequently by both inpatients and the MMPI-2 normative sample. The new scales construct validity was examined through tests of a series of hypotheses derived from an analysis of the reasons for elevated Infrequency (F) and Infrequency-Back (Fb) scores in inpatient settings. The F(p) scales incremental validity was explored by comparing its performance to that of the F scale. The results of this study suggest that F(p) may be used as an adjunct to F in settings characterized by relatively high base rates of psychopathology and psychological distress. An important feature contributing to the clinical usefulness of the Minnesota Multiphasic Personality Inventory—2 (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) is the availability of scales that assess the validity of individual test protocols. The importance of appraising the validity of individual test scores was recognized by Hathaway and McKinley (1943), who included two validity scales, Lie (L) and Infrequency (F) in the original version of the MMPI. The F scale was developed as an infrequent-response indicator by identifying 64 items that were answered infrequently in the

Facilitation of working memory in humans by a d2 dopamine receptor agonist

Recent studies on the neurobiology of cognition have focused on the ability of the prefrontal cortex (PFC) to support processes of working memory, i.e, mnemonic processes by which information relevant for a correct response is temporarily maintained to be reevaluated or updated on a trial-by-trial basis. Of most recent interest is the role played by dopamine (DA) in spatial working memory processes of the principal sulcal region of the PFC. Although D1 DA receptors appear to modulate these mnemonic processes in monkeys, several lines of research suggest that D2 DA receptors could also be relevant to cognitive functions. Therefore, we assessed the effects of a specific D2 receptor agonist (bromocriptine) and placebo on visuospatial delayed response performance in human subjects. During delay periods of 0 or 8 sec, subjects were required to remember the spatial location of rapidly presented visual cues displayed in peripheral vision within a 360 circumference. The extent to which D2 receptor activation by bromocriptine facilitated working memory in the 8sec delay condition relative to placebo performance was assessed. As a means of providing validation of bromocriptines D2 receptor effect, maximum inhibition of prolactin (PRL) secretion, which is inhibited specifically by activation of D2 receptor sites, was determined. Additionally, tasks having no working memory component were administered to rule out nonspecific effects of bromocriptine on sensory, arousal, attentional, and motor factors. Results demonstrated a significant facilitatory effect of bromocriptine on spatial delayed response performance (i.e., 8sec delay performance). Results could not be explained by nonspecific effects of bromocriptine. Thus, findings of this study suggest that spatial working memory is facilitated by D2 receptor activation. The role that DA may play in human cognitive processes is discussed within the larger theoretical framework of DAs general role in the facilitation of goal-directed behavior. In the case of cognition, DA may facilitate processes that serve to guide motivated behavior through complex environments.

Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality.

Modern trait theories of personality include a dimension reflecting positive emotionality (PE) based on sensitivity to signals of incentive-reward. In animals, responsivity within an emotional system analog of PE is dependent on brain dopamine (DA) activity. To determine whether human PE trait levels are also associated with central DA, effects of a specific DA D2 receptor agonist were assessed in Ss who were widely distributed along the trait dimension of PE. The degree of agonist-induced reactivity in two distinct central DA indices was strongly and specifically associated with trait levels of PE, but not with other personality traits. The results suggest that the trait structure of personality may be related to individual differences in brain DA functioning.

General Behavior Inventory Identification of Unipolar and Bipolar Affective Conditions in a Nonclinical University Population

Validated the General Behavior Inventory (GBI), revised to identify unipolar as well as bipolar affective conditions, in a nonclinical sample (n = 201) against naive, interview-derived diagnoses. For bipolar and unipolar conditions, respectively, the GBI had high positive (.94, .87) and negative (.99, .93) predictive power with the effect of prevalence considered, adequate sensitivity (.78, .76), high specificity (.99, .99), and adequate selection ratios for sampling of affective and nonaffective subjects from nonclinical populations for research purposes. The utility of the GBI in several different research contexts is discussed.

Regional electroencephalographic asymmetries in bipolar seasonal affective disorder before and after exposure to bright light

Electroencephalographic (EEG) asymmetries found in nonseasonal depression were examined in seasonal affective disorder before and after bright-light exposure. Subjects with seasonal depression demonstrated the expected pattern of frontal asymmetry both when depressed and following light-induced remission. Right-hemisphere EEG coherence, by contrast, served as a state-dependent indicator of seasonal depression.

Early Mental Health Treatment-Seeking Among U.S. National Guard Soldiers Deployed to Iraq

The authors examined rates of and factors associated with postdeployment treatment-seeking in a panel of 424 National Guard soldiers who spent 16 months in Iraq. Soldiers completed a self-report, mailed survey 3- to 6-months after returning home. Approximately one third of respondents reported postdeployment mental health treatment. Those who screened positive for mental health problems were more likely to indicate that they had received treatment compared to those who screened negative, but over one half of those who screened positive were not engaged with mental health treatment. Variables related to reported treatment receipt included positive attitudes about mental health therapies, having been injured in-theater, illness-based need, and having received mental health treatment while in-theater. Implications and future research directions are discussed.

Psychiatric diagnoses, comorbidity, and functioning in National Guard troops deployed to Iraq

OBJECTIVE Over 1.8 million troops have been deployed to Iraq (OIF) and Afghanistan. Estimates of mental health problems postdeployment have been based on screening instruments; no studies have examined the postdeployment mental health of troops returning from OIF using structured diagnostic interviews. The goal of the current study is to (a) report on rates of mental health diagnoses and comorbidity in soldiers after deployment to OIF using clinical interviews, and (b) examine the relationship between mental health diagnoses and overall functioning and quality of life. METHOD Participants were 348 National Guard soldiers drawn from the Readiness and Resilience in National Guard Soldiers (RINGS) study, a longitudinal study of mental health after deployment to OIF from March 2006 to July 2007. Participants completed clinical interviews, including the Clinician Administered PTSD Scale and the Structured Clinical Interview for the DSM-IV, and self-report measures of social adjustment and quality of life 6-12 months following deployment. RESULTS Most participants did not meet criteria for a mental health diagnosis. Non-PTSD anxiety disorders and depressive disorders were the most common. Mental health diagnoses were associated with poorer functioning and quality of life. PTSD had the strongest relationship with social functioning and quality of life. For those with PTSD, comorbid diagnoses were not associated with an incremental decrease in functioning or quality of life. CONCLUSIONS The findings highlight the significant rate and burden of mental health disorders among this population and suggest that while PTSD is relatively uncommon, it is a particularly deleterious disorder.

Examination of the MMPI-2 Restructured Form (MMPI-2-RF) Validity Scales in Civil Forensic Settings: Findings from Simulation and Known Group Samples

The current study examined the effectiveness of the MMPI-2 Restructured Form (MMPI-2-RF; Ben-Porath and Tellegen, 2008) over-reporting indicators in civil forensic settings. The MMPI-2-RF includes three revised MMPI-2 over-reporting validity scales and a new scale to detect over-reported somatic complaints. Participants dissimulated medical and neuropsychological complaints in two simulation samples, and a known-groups sample used symptom validity tests as a response bias criterion. Results indicated large effect sizes for the MMPI-2-RF validity scales, including a Cohens d of .90 for Fs in a head injury simulation sample, 2.31 for FBS-r, 2.01 for F-r, and 1.97 for Fs in a medical simulation sample, and 1.45 for FBS-r and 1.30 for F-r in identifying poor effort on SVTs. Classification results indicated good sensitivity and specificity for the scales across the samples. This study indicates that the MMPI-2-RF over-reporting validity scales are effective at detecting symptom over-reporting in civil forensic settings.

The ability of minnesota multiphasic personality inventory - 2 validity scales to detect fake-bad responses in psychiatric inpatients

The effectiveness of P. A. Arbisi and Y. S. Ben-Poraths (1995) Infrequency-Psychopathology Scale, F(p), in discriminating between groups of psychiatric inpatients who were administered the Minnesota Multiphasic Personality Inventory-2 (J. N. Butcher, W. G. Dahlstrom, J. R. Graham, A. Tellegen, & B. Kaemmer, 1989) under 2 scripted conditions, honest and fake bad, was examined. The F(p) scales incremental validity, in reference to the Infrequency (F) scale, was tested with 74 Minneapolis Veteran Affairs Medical Center inpatients (64 men and 10 women). The results support the use of F(p) in the detection of malingering in psychiatric patients and indicate that in settings characterized by high base rates of psychopathology, F(p) outperforms F and accounts for all the predictive power when distinguishing between psychiatric inpatients responding honestly and attempting to fake bad.

Updated meta-analysis of the MMPI-2 symptom validity scale (FBS): verified utility in forensic practice

Clinical research interest in the symptom reporting validity scale currently known as the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Symptom Validity Scale (FBS) has continued to be strong, with multiple new publications annually in peer-reviewed journals that publish psychological and neuropsychological assessment research. Related to this growth in relevant literature, the present study was conducted to update the Nelson, Sweet, and Demakis (2006b) FBS meta-analysis. A total of 83 FBS studies (43 new studies) were identified, and 32 (38.5%) met inclusion criteria. Analyses were conducted on a pooled sample of 2218 over-reporting and 3123 comparison participants. Large omnibus effect sizes were observed for FBS, Obvious-Subtle (O-S), and the Dissimulation Scale-Revised (Dsr2) scales. Moderate effect sizes were observed for the following scales: Back Infrequency (Fb), Goughs F-K, Infrequency (F), Infrequency Psychopathology (Fp), and Dissimulation (Ds2). Moderator analyses illustrate that relative to the F-family scales, FBS exhibited larger effect sizes when (1) effort is known to be insufficient and (2) evaluation is conducted in the context of traumatic brain injury. Overall, current results summarize an extensive literature that continues to support use of FBS in forensic neuropsychology practice.