Paul C. Levy
University of Rochester
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Publication
Featured researches published by Paul C. Levy.
Cellular Immunology | 1978
George M. Shaw; Paul C. Levy; Albert F. LoBuglio
This study demonstrates that all three Fc receptor bearing leukocytes (monocytes, granulocytes, and lymphocytes) are capable of antibody-dependent cellular cytotoxicity toward normal O+ (R 1 R 2 ) and -D- red cells coated with certain antibodies. ADCC was temperature dependent, rapid and positively related to the effector/target ratio for all three effectors. In this system, lymphocytes and granulocytes required greater amounts of antibody for optimal ADCC as compared to monocytes. Gamma globulin inhibition of ADCC occurred at low concentration with granulocytes (1 g/ml), intermediate with monocytes (5 g/ml) and high concentration with lymphocytes (500 g/ml). No evidence for a soluble mediator of red cell lysis was found with any effector cell system. We suggest that this experimental system which involves three Fc receptor bearing human leukocytes and identical target cell and antibody preparations provides a new and unique method for studying the ADCC event.
Inhalation Toxicology | 1994
Jonathan B. Gavras; Mark W. Frampton; Daniel H. Ryan; Paul C. Levy; R. John Looney; Christopher Cox; Paul E. Morrow; Mark J. Utell
AbstractEvidence from both animal and human investigations suggests that exposure to nitrogen dioxide (NO2,), a common air pollutant, increases susceptibility to respiratory infections. In animals, alveolar macrophage (AM) antimicrobial functions are impaired following NO2 exposure. We sought to determine whether exposure to NO2 in humans causes an influx of less mature AM into the alveolar space and/or results in decreased expression of AM surface markers important in antimicrobial defense. Eight human volunteers underwent bronchoalveolar lavage (BAL) immediately following 6-h exposures to 2.0 ppm NO2 or filtered air. AM expression of receptors for the Fc component of immunoglobulin (Ig), complement receptor 3 (CD11b), and monocyte marker CD14 were assessed using imniunofluorescence staining and flow cytometry. The use of internal fluorescence standards reduced analytical variability by 32% and allowed detection of relatively small changes in cell surface antigen expression. We observed an increase in AM...
Journal of Immunology | 1979
Paul C. Levy; George M. Shaw; Albert F. LoBuglio
Blood | 1992
Hb Fleit; Cd Kobasiuk; C Daly; R Furie; Paul C. Levy; Ro Webster
Journal of Clinical Investigation | 1978
George M. Shaw; Paul C. Levy; Albert F. LoBuglio
Journal of Immunology | 1978
George M. Shaw; Paul C. Levy; Albert F. LoBuglio
Blood | 1991
Barry M. Goldstein; James F. Leary; Barbara A. Farley; Victor E. Marquez; Paul C. Levy; Peter T. Rowley
Environmental Research | 1995
Mark W. Frampton; Paul E. Morrow; Christopher Cox; Paul C. Levy; J.J. Condemi; Donna M. Speers; F. R. Gibb; Mark J. Utell
Blood | 1978
George M. Shaw; Paul C. Levy; Albert F. LoBuglio
Chest | 1994
Robert H. Poe; Paul C. Levy; Robert H. Israel; Carlos R. Ortiz; Michael C. Kallay