Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Paul C. Levy is active.

Publication


Featured researches published by Paul C. Levy.


Cellular Immunology | 1978

Human lymphocyte, monocyte, and neutrophil antibody-dependent cell-mediated cytotoxicity toward human erythrocytes

George M. Shaw; Paul C. Levy; Albert F. LoBuglio

This study demonstrates that all three Fc receptor bearing leukocytes (monocytes, granulocytes, and lymphocytes) are capable of antibody-dependent cellular cytotoxicity toward normal O+ (R 1 R 2 ) and -D- red cells coated with certain antibodies. ADCC was temperature dependent, rapid and positively related to the effector/target ratio for all three effectors. In this system, lymphocytes and granulocytes required greater amounts of antibody for optimal ADCC as compared to monocytes. Gamma globulin inhibition of ADCC occurred at low concentration with granulocytes (1 g/ml), intermediate with monocytes (5 g/ml) and high concentration with lymphocytes (500 g/ml). No evidence for a soluble mediator of red cell lysis was found with any effector cell system. We suggest that this experimental system which involves three Fc receptor bearing human leukocytes and identical target cell and antibody preparations provides a new and unique method for studying the ADCC event.


Inhalation Toxicology | 1994

Expression of membrane antigens on human alveolar macrophages after exposure to nitrogen dioxide

Jonathan B. Gavras; Mark W. Frampton; Daniel H. Ryan; Paul C. Levy; R. John Looney; Christopher Cox; Paul E. Morrow; Mark J. Utell

AbstractEvidence from both animal and human investigations suggests that exposure to nitrogen dioxide (NO2,), a common air pollutant, increases susceptibility to respiratory infections. In animals, alveolar macrophage (AM) antimicrobial functions are impaired following NO2 exposure. We sought to determine whether exposure to NO2 in humans causes an influx of less mature AM into the alveolar space and/or results in decreased expression of AM surface markers important in antimicrobial defense. Eight human volunteers underwent bronchoalveolar lavage (BAL) immediately following 6-h exposures to 2.0 ppm NO2 or filtered air. AM expression of receptors for the Fc component of immunoglobulin (Ig), complement receptor 3 (CD11b), and monocyte marker CD14 were assessed using imniunofluorescence staining and flow cytometry. The use of internal fluorescence standards reduced analytical variability by 32% and allowed detection of relatively small changes in cell surface antigen expression. We observed an increase in AM...


Journal of Immunology | 1979

Human monocyte, lymphocyte, and granulocyte antibody-dependent cell-mediated cytotoxicity toward tumor cells. I. General characteristics of cytolysis.

Paul C. Levy; George M. Shaw; Albert F. LoBuglio


Blood | 1992

A soluble form of Fc gamma RIII is present in human serum and other body fluids and is elevated at sites of inflammation

Hb Fleit; Cd Kobasiuk; C Daly; R Furie; Paul C. Levy; Ro Webster


Journal of Clinical Investigation | 1978

Human Monocyte Antibody-Dependent Cell-Mediated Cytotoxicity to Tumor Cells

George M. Shaw; Paul C. Levy; Albert F. LoBuglio


Journal of Immunology | 1978

Human Monocyte Cytotoxicity to Tumor Cells: I. Antibody-Dependent Cytotoxicity

George M. Shaw; Paul C. Levy; Albert F. LoBuglio


Blood | 1991

Induction of HL60 Cell Differentiation by Tiazofurin and Its Analogues: Characterization and Efficacy

Barry M. Goldstein; James F. Leary; Barbara A. Farley; Victor E. Marquez; Paul C. Levy; Peter T. Rowley


Environmental Research | 1995

Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects

Mark W. Frampton; Paul E. Morrow; Christopher Cox; Paul C. Levy; J.J. Condemi; Donna M. Speers; F. R. Gibb; Mark J. Utell


Blood | 1978

Human lymphocyte antibody-dependent cell-mediated cytotoxicity (ADCC) toward human red blood cells.

George M. Shaw; Paul C. Levy; Albert F. LoBuglio


Chest | 1994

Use of Fiberoptic Bronchoscopy in the Diagnosis of Bronchogenic Carcinoma: A Study in Patients With Idiopathic Pleural Effusions

Robert H. Poe; Paul C. Levy; Robert H. Israel; Carlos R. Ortiz; Michael C. Kallay

Collaboration


Dive into the Paul C. Levy's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge