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Paul Coucke

University of Liège

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Featured researches published by Paul Coucke.

Phytochemistry | 1991

Matadine, a cytotoxic alkaloid from Strychnos gossweileri

Joëlle Quetin-Leclercq; Paul Coucke; Clément Delaude; Roger Warin; Roger Bassleer; Luc Angenot

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells.

Planta Medica | 1994

Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro.

S. Danloy; Joëlle Quetin-Leclercq; Paul Coucke; Marie-Caroline De Pauw-Gillet; Riad Elias; Guy Balansard; Luc Angenot; Roger Bassleer

Anticancer Research | 1991

CYTOTOXIC AND MITOGENIC ACTIVITIES IN CULTURE MEDIA CONDITIONED BY MOUSE B16 MELANOMA CELLS AND 3T3 FIBROBLASTS

Brigitte Siwek; Jacques Wauthy; Paul Coucke; Marie-Claire De Pauw-Gillet; Roger Bassleer

Invasion & Metastasis | 1993

Reevaluation by Image Analysis of the Effects of Fibroblasts, Fibronectin or Laminin Upon Colony Formation in Mouse Lungs by B16 Melanoma Cells

Paul Coucke; M. Lambertz; E. N. Baramova; Marie-Claire De Pauw-Gillet; Jean-Michel Paulus; Roger Bassleer; Jean-Michel Foidart

in Vivo | 1994

Characterization and Tumorigenicity of Spheroids Composed of Pigmented or Non Pigmented B16 Melanoma Cells

Paul Coucke; Marie-Claire De Pauw-Gillet; Karine Bonjean; Brigitte Siwek; Jean-Michel Foidart; Roger Bassleer

Archive | 1993

Effects of α-Hederin on cells cultured in vitro

Joëlle Quetin-Leclercq; Sophie Danloy; Paul Coucke; Marie-Claire De Pauw-Gillet; Riad Elias; L Balansard; Bassleer

Réunion de l'Association Belge pour l'Etude du Cancer (ABEC) | 1990

Cytotoxic activities exerted by low molecular weight fractions present in culture media conditioned by mouse B16 melanoma cells and 3 T 3 fibroblasts.

Brigitte Siwek; Jacques Wauthy; Paul Coucke; Marie-Claire De Pauw-Gillet; Joëlle Quetin-Leclercq; Luc Angenot; Sergio Facchetti; Enrico Sabbioni; Roger Bassleer

Archive | 1990

Influence of laminin and fibroblasts upon colony formation by B16 melanoma cells

Laurence de Leval; Philippe Leyh; Dominique Grégoire; Brigitte Siwek; Paul Coucke; Marie-Claire De Pauw-Gillet; M Smet; Jean Claude Grosdent; Jean-Michel Paulus; Roger Bassler; Jean-Michel Foidart

Archive | 1990

Characterization of tridimensional mixed cultures of mouse B16 melanoma cells and 3T3 fibroblasts

Paul Coucke; Brigitte Siwek; Carine Munaut; Marie-Claire De Pauw-Gillet; Agnès Noël; Karine Bonjean; Jean-Michel Foidart; Roger Bassleer

Archive | 1990

Cytotoxic activities exerted by low M.W. fractions present in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts

Brigitte Siwek; Jacques Wauthy; Paul Coucke; Marie-Claire De Pauw-Gillet; Joëlle Quetin-Leclercq; Luc Angenot; Sergio Facchetti; Enrico Sabbioni; Roger Bassleer

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Marie-Claire De Pauw-Gillet

University of Liège

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Roger Bassleer

University of Liège

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Brigitte Siwek

University of Liège

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Jean-Michel Foidart

University of Liège

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Joëlle Quetin-Leclercq

Université catholique de Louvain

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Luc Angenot

University of Liège

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Jean-Michel Paulus

University of Liège

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Karine Bonjean

University of Liège

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Agnès Noël

University of Liège

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Carine Munaut

University of Liège

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