Paul D. Freedman

Gingival hyperplasia associated with nifedipine therapy. Report of a case

A case of gingival hyperplasia associated with the administration of nifedipine is reported. Clinically and histologically, the tissue resembled that seen in hyperplasia induced by phenytoin (Dilantin). We believe this to be the first reported case of gingival hyperplasia associated with this drug.

Lobular carcinoma of intraoral minor salivary gland origin: Report of twelve cases

In an attempt to define more accurately the tumors grouped under the heading of adenocarcinoma of salivary gland origin, we reviewed the cases in our registry that were classified as adenocarcinoma, carcinoma of salivary gland origin, and infiltrating epithelial salivary gland tumors. Eleven tumors that had certain unique microscopic features in common were identified. These eleven tumors and one that was reviewed in consultation make up the basis of this study. We classified these lesions as lobular carcinoma of salivary gland origin because of their remarkable microscopic resemblance to the breast tumors of the same name. These lesions appear to be of low-grade malignancy and have not recurred or metastasized in any of the eleven cases for which we have follow-up data, at times ranging from 5 to 80 months.

Mucormycosis of the oral cavity.

Mucormycosis (phycomycosis, zygomycosis) is an acute opportunistic infection caused by a saprophytic fungus found in soil, bread molds, and decaying fruits and vegetables. Numerous predisposing risk factors are associated with mucormycosis, although most cases have been reported in poorly controlled diabetics or in patients with hematologic malignant conditions. This report presents two cases of oral mucormycosis. One case occurred in the maxilla in a patient with well-controlled diabetes. The other involved the mandible and overlying gingiva in a patient with acute myelogenous leukemia. A review of the literature concerning oral mucormycosis is also presented.

Major aphthous-like ulcers in patients with AIDS

This report describes persistent, painful oral ulcers that occurred in nine patients with the acquired immunodeficiency syndrome (AIDS). These ulcers resembled major aphthous ulcers in clinical appearance and response to therapy. They occurred less frequently in patients with AIDS than those caused by herpes simplex and were found in 4 of 346 (1.1%) patients with AIDS at one medical center. Lesions were typically painful. Identification and treatment with topical tetracycline and steroids led to resolution with relief of symptoms. Further study is necessary to understand the etiology and pathogenesis of these ulcers.

Cytomegalovirus infections of the oral cavity: A report of six cases and review of the literature

Cytomegalovirus is responsible for a significant percentage of asymptomatic viral infections worldwide. Although virtually any cell or organ may be infected, involvement of the oral cavity is uncommon. Only nine well-documented examples of intraoral cytomegalovirus infections were found in a review of the English-language literature. We report six additional examples, five of which possessed unique clinical and histopathologic characteristics. The light and electron-microscopic features of cytomegalovirus are discussed, as well as diagnostic adjuncts such as immunohistochemistry and deoxyribonucleic acid in situ hybridization.

Recurrent botryoid odontogenic cyst (lateral periodontal cyst)

The terms botryoid odontogenic cyst and lateral periodontal cyst have both been used to describe a histologically distinct type of cyst characterized by a thin epithelial lining exhibiting focal thickenings or plaques. The cyst reported herein is a well-documented example of this type of cyst, which exhibited persistent and recurrent behavior.

Benign fibrous histiocytoma of the maxilla

Benign fibrous histiocytomas of bone are unusual neoplasms that often are confused with metaphyseal fibrous defects. Although the two lesions have overlapping microscopic characteristics, they differ in their clinicopathologic presentations. This report describes the clinicopathologic features of the first reported case of benign fibrous histiocytoma involving the maxilla and the fourth description of this tumor in the jawbones. In addition, the concept of fibrohistiocytic lesions of bone is discussed with consideration of their pathologic classification and their clinical, radiographic, and microscopic differential diagnosis.

Benign mesenchymoma of the oral soft tissues

Abstract Benign mesenchymoma is a mixed tumor of mesenchymal derivatives. These tumors are composed of an admixture of two or more benign mesenchymal components in addition to fibrous tissue. A case of benign mesenchymoma of the base of the tongue in a 2 1 2 - year-old girl is presented. The literature is reviewed and discussed.

Epithelioid angiosarcoma of the maxilla : a case report and review of the literature

Epithelioid angiosarcoma is a rare vascular tumor composed of a proliferation of cytologically malignant epithelioid endothelial cells. These tumors are fully malignant and can pursue a rapidly progressive course. A case of primary epithelioid angiosarcoma of the maxilla is presented. Also discussed is a review of the literature with emphasis on the concept of epithelioid endothelial cell tumors.

The synchronous occurrence of aspergillosis and myospherulosis of the maxillary sinus: Report of a case with review of the literature

Antecedent dintervention de Caldwell Luc avec adjonction dune pommade antibiotique petrolatum (qui est responsable de la myospherulose)