Paul Désiré Djomeni Dzeufiet
University of Yaoundé I
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Featured researches published by Paul Désiré Djomeni Dzeufiet.
Pharmaceutical Biology | 2011
Germain Sotoing Taïwe; Elisabeth Ngo Bum; Emmanuel Talla; Théophile Dimo; Norbert Weiss; Neteydji Sidiki; Amadou Dawé; Fleur Clarisse Okomolo Moto; Paul Désiré Djomeni Dzeufiet; Michel De Waard
Context: Nauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas in Africa. It is used in traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc. Objective: The aim of this study was to investigate the effects of Nauclea latifolia roots decoction on the peripheral and central nervous systems and its possible mechanisms of action. Materials and methods: The analgesic investigation was carried out against acetic acid-induced writhing, formalin-induced pain, hot-plate and tail immersion tests. The antipyretic activity was studied in Brewer’s yeast-induced pyrexia in mice. Rota-rod test and bicuculline-induced hyperactivity were used for the assessment of locomotor activity. Results: Nauclea latifolia induced hypothermia and had antipyretic effects in mice. The plant decoction produced significant antinociceptive activity in all analgesia animal models used. The antinociceptive effect exhibited by the decoction in the formalin test was reversed by the systemic administration of naloxone, Nω-l-nitro-arginine methyl ester or glibenclamide. In contrast, theophylline did not reverse this effect. Nauclea latifolia (antinociceptive doses) did not exhibit a significant effect on motor coordination of the mice in Rota-rod performance. Nauclea latifolia protected mice against bicuculline-induced behavioral excitation. Discussion and conclusion: Overall, these results demonstrate that the central and peripheral effects of Nauclea latifolia root decoction might partially or wholly be due to the stimulation of peripheric opioid receptors through the action of the nitric oxide/cyclic monophosphate guanosin/triphosphate adenosine (NO/cGMP/ATP)-sensitive- K+ channel pathway and/or facilitation of the GABAergic transmission.
Journal of Ethnopharmacology | 2012
Germain Sotoing Taïwe; Elisabeth Ngo Bum; Emmanuel Talla; Théophile Dimo; Neteydji Sidiki; Amadou Dawé; Richard Marcel Nguimbou; Paul Désiré Djomeni Dzeufiet; Michel De Waard
ETHNOPHARMACOLOGICAL RELEVANCE The leaves of Crassocephalum bauchiense have long been used in traditional Cameroonian medicine for the treatment of epilepsy, pain, inflammatory disorders, arthritis and intestinal pain. AIM OF THE STUDY In this study, we attempted to identify the possible antinociceptive action of the aqueous extract and the alkaloid fraction prepared from the leaves of Crassocephalum baucheiense. MATERIALS AND METHODS Using acetic acid induced abdominal constrictions, formalin-, capsaisin- and glutamate-induced nociception, and hot plate assay procedures, the antinociceptive effects of the aqueous extract and the alkaloid fraction was assessed after oral administration in mice. Morphine sulfate was used as reference analgesic agent. Mice were submitted to the rota-rod task and open-field test in order to assess any non-specific muscle-relaxant or sedative effects of the extracts of Crassocephalum bauchiense. Male and female Swiss mice were used to assess acute toxicity of these extracts. RESULTS The aqueous extract and the alkaloid fraction of Crassocephalum bauchiense produced a significant antinociceptive effects in the acetic acid, formalin, glutamate, capsaicin and hot plate tests. These antinociceptive effects of Crassocephalum bauchiense were significantly attenuated by pretreatment with naloxone. The extracts of Crassocephalum bauchiense did not alter the locomotion of animals in the open-field or rotarod tests, which suggest a lack of a central depressant effect. The animals did not exhibit any acute toxicity to the aqueous extract and the alkaloid fraction, so it was not possible to calculate the LD(50). CONCLUSION The results confirm the popular use of Crassocephalum bauchiense as an antinociceptive, and contribute to the pharmacological knowledge of this species because it was shown that the aqueous extract and the alkaloid fraction of Crassocephalum bauchiense produced dose related antinociception in models of chemical and thermal nociception through mechanisms that involve an interaction with opioidergic pathway.
Journal of basic and clinical physiology and pharmacology | 2017
Germain Sotoing Taïwe; Arielle Larissa Ndieudieu Kouamou; Armelle Rosalie Mbang Ambassa; Joseph Renaud Menanga; Thierry Bang Tchoya; Paul Désiré Djomeni Dzeufiet
Abstract Background: The root bark of Anthocleista djalonensis A. Chev. (Loganiaceae) is widely used in traditional medicine in Northern Cameroon to treat epilepsy and related conditions, such as migraine, insomnia, dementia, anxiety, and mood disorders. Methods: To investigate the anticonvulsant effects and the possible mechanisms of this plant, an aqueous extract of Anthocleista djalonensis (AEAD) was evaluated by using animal models of bicuculline-, picrotoxin-, pilocarpine-, and pentylenetetrazole-induced convulsions. Their effects on brain γ-aminobutyric acid (GABA) concentration and GABA-T activity were also determined. Results: This extract significantly protected mice against bicuculline-induced motor seizures. It provided 80% protection against picrotoxin-induced tonic-clonic seizures, and strongly antagonized convulsions induced by pilocarpine. AEAD also protected 100% of mice against pentylenetetrazole-induced seizures. Flumazenil, a central benzodiazepine receptor antagonist and FG7142, a partial inverse agonist in the benzodiazepine site of the GABAA receptor complex, were found to have an inhibitory effect on the anticonvulsant action of AEAD in pentylenetetrazole test. Finally, the brain GABA concentration was significantly increased and GABA-T activity was inhibited by AEAD. Conclusions: The effects of Anthocleista djalonensis suggested the presence of anticonvulsant properties that might involve an action on benzodiazepine and/or GABA sites in the GABAA receptor complex or by modulating GABA concentration in the central nervous system (CNS).
African Journal of Traditional, Complementary and Alternative Medicines | 2005
Léonard Tédong; Théophile Dimo; Paul Désiré Djomeni Dzeufiet; Acha Emmanuel Asongalem; Dongmo Selestin Sokeng; Patrice Callard; Jean–François Flejou; Pierre Kamtchouing
International Journal of Pharmacology | 2010
Germain Sotoing Taïwe; E. Ngo Bum; Théophile Dimo; Emmanuel Talla; Norbert Weiss; Amadou Dawe; Fleur Clarisse Okomolo Moto; Neteydji Sidiki; Paul Désiré Djomeni Dzeufiet; M. de Waard
Journal of Ethnopharmacology | 2012
Germain Sotoing Taïwe; Elisabeth Ngo Bum; Emmanuel Talla; Amadou Dawe; Fleur Clarisse Okomolo Moto; Gwladys Temkou Ngoupaye; Neteydji Sidiki; Bernard Dabole; Paul Désiré Djomeni Dzeufiet; Théophile Dimo; Michel De Waard
BMC Complementary and Alternative Medicine | 2014
Paul Désiré Djomeni Dzeufiet; Amélie Mogueo; Danielle Claude Bilanda; Bibi-Farouck Oumarou Aboubakar; Léonard Tédong; Théophile Dimo; Pierre Kamtchouing
BMC Complementary and Alternative Medicine | 2016
Germain Sotoing Taïwe; Bernard Dabole; Thierry Bang Tchoya; Joseph Renaud Menanga; Paul Désiré Djomeni Dzeufiet; Michel De Waard
BMC Complementary and Alternative Medicine | 2015
Florence Tsofack Ngueguim; Eloi Christian Esse; Paul Désiré Djomeni Dzeufiet; Raceline Gounoue; Danielle Claude Bilanda; Pierre Kamtchouing; Théophile Dimo
Archive | 2014
Paul Désiré Djomeni Dzeufiet; Danielle Claude Bilanda; Yolande Sandrine Mengue Ngadena; Mireille Kameni Poumeni; David Nana