Paul G. Richardson
Broad Institute
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Featured researches published by Paul G. Richardson.
Cancer Cell | 2014
Jens Lohr; Petar Stojanov; Scott L. Carter; Peter Cruz-Gordillo; Michael S. Lawrence; Daniel Auclair; Carrie Sougnez; Birgit Knoechel; Joshua Gould; Gordon Saksena; Kristian Cibulskis; Aaron McKenna; Michael Chapman; Ravid Straussman; Joan Levy; Louise M. Perkins; Jonathan J. Keats; Steven E. Schumacher; Mara Rosenberg; Kenneth C. Anderson; Paul G. Richardson; Amrita Krishnan; Sagar Lonial; Jonathan L. Kaufman; David Siegel; David H. Vesole; Vivek Roy; Candido E. Rivera; S. Vincent Rajkumar; Shaji Kumar
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity. We observed frequent mutations in KRAS (particularly in previously treated patients), NRAS, BRAF, FAM46C, TP53, and DIS3 (particularly in nonhyperdiploid MM). Mutations were often present in subclonal populations, and multiple mutations within the same pathway (e.g., KRAS, NRAS, and BRAF) were observed in the same patient. In vitro modeling predicts only partial treatment efficacy of targeting subclonal mutations, and even growth promotion of nonmutated subclones in some cases. These results emphasize the importance of heterogeneity analysis for treatment decisions.
Archive | 2011
Im Ghobrial; Paul G. Richardson; Kenneth C. Anderson
Bortezomib in the treatment of multiple myeloma , Bortezomib in the treatment of multiple myeloma , کتابخانه دیجیتال جندی شاپور اهواز
Archive | 2017
Jacalyn Rosenblatt; Baldev Vasir; Lynne Uhl; Simona Blotta; Claire MacNamara; Poorvi Somaiya; Zekui Wu; Robin M. Joyce; James D. Levine; Dilani Dombagoda; Yan Emily Yuan; Karen Francoeur; Donna Fitzgerald; Paul G. Richardson; Edie Weller; Kenneth C. Anderson; Donald Kufe; Nikhil C. Munshi; David Avigan
Archive | 2017
Im Ghobrial; Federico Campigotto; Timothy J. Murphy; Erica N Boswell; Ranjit Banwait; Feda Azab; Stacey Chuma; Janet Kunsman; Amanda Donovan; Farzana Masood; Diane Warren; Scott J. Rodig; Kenneth C. Anderson; Paul G. Richardson; Edie Weller; Jeffrey Matous
Archive | 2016
Richard Rickles; Laura T. Pierce; Thomas P. Giordano; Winnie F. Tam; Douglas W. McMillin; Jake Delmore; Jacob Laubach; Alexis Borisy; Paul G. Richardson; Margaret S. Lee
Archive | 2013
Kenneth C. Anderson; Tuan Pham; Qingping Zeng; John B. Patterson; Paul G. Richardson; Nikhil C. Munshi; Maureen French; Martina Blumenthal; Victor Tam; Nathalie L. Kertesz; Uriel M. Malyankar; Yiguo Hu; Claire Fabre; Jiro Minami; Hiroto Ohguchi; Tanyel Kiziltepe; Hiroshi Ikeda; Mariateresa Fulciniti; Gullu Gorgun; Diana Cirstea; Loredana Santo
Archive | 2013
Dharminder Chauhan; Kenneth C. Anderson; Teru Hideshima; Masaharu Akiyama; Toshiaki Hayashi; Paul G. Richardson; Robert L. Schlossman
Archive | 2013
Kenneth C. Anderson; Toshiaki Hayashi; Teru Hideshima; Masaharu Akiyama; Noopur Raje; Paul G. Richardson
Archive | 2013
Min Chen; Mohamad H. Zaki; Christian Jacques; Laura McBride; Elizabeth Bilotti; Palka Anand; Lisa Nardelli; Gail Larkins; Daniel C. Sullivan; Melissa Alsina; Robert L. Schlossman; Im Ghobrial; Deborah Doss; Paul G. Richardson; David S. Siegel; Rachid Baz; Susan L. Kelley; Nikhil C. Munshi; Jacob Laubach
Archive | 2013
Teru Hideshima; Dharminder Chauhan; Kenneth C. Anderson; Renate Burger; Robert L. Schlossman; Paul G. Richardson; Lini Pandite; Laurence Catley; Reshma Shringarpure; Pedro Carvalho
