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Dive into the research topics where Paul G. Updike is active.

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Featured researches published by Paul G. Updike.


Investigative Ophthalmology & Visual Science | 2008

Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration.

Sandra Liakopoulos; Sharel C. Ongchin; Alok Bansal; Sandeep Msutta; Alexander C. Walsh; Paul G. Updike; Srinivas R. Sadda

PURPOSE To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD). METHODS Sixty-six cases of previously untreated, active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. CNV lesions were classified as occult with no classic CNV, minimally classic CNV, predominantly classic CNV, or CNV lesions with associated retinal angiomatous proliferation (RAP). Corresponding OCT image sets were analyzed by trained graders using previously validated custom software that allows manual placement of boundaries on OCT B-scans. Spaces delineated by these boundaries included the neurosensory retina, subretinal fluid, subretinal tissue, and pigment epithelial detachments (PEDs). Volume measurements were calculated by the software and compared among groups. RESULTS Minimally and predominantly classic CNV membranes demonstrated subretinal tissue on OCT in all cases and appeared to show a significantly greater volume of subretinal tissue than did the occult membranes. Subretinal fluid was present in all the predominantly classic cases. A PED was visible in all the occult CNV cases in our study, demonstrating less retinal thickening and significantly greater PED volumes than minimally and predominantly classic CNV lesions. Lesions associated with RAP showed the highest percentage of cystoid spaces. CONCLUSIONS OCT and angiography provide complementary information regarding CNV lesions. Quantitative analysis of OCT images allows for an improved understanding of the anatomic characteristics of angiographically defined CNV lesion subtypes.


Archive | 2009

Optical coherence tomography - based ophthalmic testing methods, devices and systems

Alexander C. Walsh; Paul G. Updike; Srinivas R. Sadda


Investigative Ophthalmology & Visual Science | 2007

Error correction and quantitative subanalysis of optical coherence tomography data using computer-assisted grading.

Srinivas R. Sadda; Sandra Joeres; Ziqiang Wu; Paul G. Updike; Peggy Romano; Allyson T. Collins; Alexander C. Walsh


Archive | 2009

Optical coherence tomography device, method, and system

Alexander C. Walsh; Paul G. Updike; Srinivas R. Sadda


Investigative Ophthalmology & Visual Science | 2007

Reproducibility of Quantitative Optical Coherence Tomography Subanalysis in Neovascular Age-Related Macular Degeneration

Sandra Joeres; Jerry W. Tsong; Paul G. Updike; Allyson T. Collins; Laurie Dustin; Alexander C. Walsh; Peggy Romano; Srinivas R. Sadda


Ophthalmology | 2008

Quantitative Comparison of Optical Coherence Tomography after Pegaptanib or Bevacizumab in Neovascular Age-Related Macular Degeneration

Sandra Joeres; Kevin Kaplowitz; Jacob W. Brubaker; Paul G. Updike; Allyson T. Collins; Alexander C. Walsh; Peggy Romano; Srinivas R. Sadda


Archive | 2009

Ophthalmic testing methods, devices and systems

Alexander C. Walsh; Paul G. Updike; Srinivas R. Sadda


Investigative Ophthalmology & Visual Science | 2007

Quantitative Fluorescein Angiographic Analysis of Choroidal Neovascular Membranes: Validation and Correlation with Visual Function

Usha Chakravarthy; Alexander C. Walsh; Alyson Muldrew; Paul G. Updike; Tara Barbour; Srinivas R. Sadda


Archive | 2013

INFLATABLE MEDICAL INTERFACES AND OTHER MEDICAL DEVICES, SYSTEMS, AND METHODS

Alexander C. Walsh; Paul G. Updike; Richard Castro


Investigative Ophthalmology & Visual Science | 2006

Zebrafish Usher Genes Are Necessary for Retinal Cell Function and Survival

Paul G. Updike; Alyson Muldrew; Srinivas R. Sadda; Alexander C. Walsh; Usha Chakravarthy

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Alexander C. Walsh

University of Southern California

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Srinivas R. Sadda

University of Southern California

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Peggy Romano

University of Southern California

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Jared Updike

University of Southern California

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Allyson T. Collins

University of Southern California

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Sandra Joeres

University of Southern California

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Mark S. Humayun

University of Southern California

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Sandeep Msutta

University of Southern California

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Sharel C. Ongchin

University of Southern California

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Alyson Muldrew

Queen's University Belfast

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