Paul Goehner
University of California, San Francisco
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Anesthesiology | 1992
Dennis T. Mangano; Deanna Siliciano; Milton Hollenberg; Jacqueline M. Leung; Warren S. Browner; Paul Goehner; Scott Merrick; Edward D. Verrier
Recent data suggest that postbypass and postoperative myocardial ischemia are related to adverse cardiac outcome following myocardial revascularization. Therapeutic trials to suppress postoperative ischemia are warranted. Because anesthetics can suppress a variety of physiologic responses to stress as well as myocardial ischemia intraoperatively, we examined whether use of intensive analgesia in the stressful postoperative period could decrease postoperative ischemia. In 106 patients undergoing elective myocardial revascularization, we standardized the anesthetic prior to bypass (sufentanil 5-10 micrograms/kg [induction] and 4.2-6.0 micrograms.kg-1.h-1 [infusion] supplemented with up to 0.5 mg/kg of diazepam). During bypass, patients were randomly assigned to receive either morphine sulfate (group M, n = 54, up to 2 mg/kg) or sufentanil (group S, n = 52, 1 microgram/kg and 1 microgram.kg-1.h-1). In the intensive care unit (ICU), group M received low-dose analgesia (morphine sulfate 1-10 mg intravenously every 30 min, average dose = 2.2 +/- 2.1 mg/h), while group S continued to receive intensive analgesia (infusion of sufentanil at 1 microgram.kg-1.h-1). Both groups received supplemental midazolam in the ICU (group M = 1.1 +/- 1.1 mg/h; group S = 0.6 +/- 0.6 mg/h; P = 0.01). All analgesic and sedative-hypnotic medications were discontinued at 18 hours following myocardial revascularization. Using continuous two-channel electrocardiographic (ECG) monitoring (CC5 and CM5), we documented and characterized ECG changes consistent with ischemia during the preoperative, intraoperative (pre- and postbypass), and postoperative (on- and off-treatment) periods. The total ECG monitoring time was 8,486 h, averaging 81 h per patient. During the prebypass (anesthetic control) period, groups M and S had a similar incidence, but group S episodes were more severe: maximum ST-segment change (median), S versus M: -1.8 mm versus -1.4 mm (P = 0.04). During the postbypass period, both groups had a similar incidence of ischemia, but episodes in group S were less severe: maximum ST-segment change, S versus M: -1.8 mm versus -2.7 mm (P = 0.0005). During the ICU-on-therapy period, the incidence of ischemic episodes was less in group S patients, and the severity was less: area-under-the-ST-time curve, S versus M: -21 mm.min versus -161 mm.min (P = 0.05). After discontinuation of the drug regimen in the ICU, the incidence and severity of ischemic episodes was similar. The incidence of hypotension, hypertension, and tachycardia was similar in both groups in both the intraoperative and ICU periods.(ABSTRACT TRUNCATED AT 400 WORDS)
JAMA | 1992
Dennis T. Mangano; Warren S. Browner; Milton Hollenberg; Juliet Li; Ida M. Tateo; Martin J. London; Julio F. Tubau; Jacqueline M. Leung; William C. Krupski; Joseph A. Rapp; Marcus W. Hedgcock; Edward D. Verrier; Scott Merrick; M. Lou Meyer; Linda Levenson; Martin G. Wong; Elizabeth Layug; Maria E. Franks; Yuriko C. Wellington; Mara Balasubramanian; Evelyn Cembrano; Wilfredo Velasco; Safiullah N. Katiby; Thea Miller; Winifred von Ehrenburg; Brian O'Kelly; Jadwiga Szlachcic; Andrew A. Knight; Virginia Fegert; Paul Goehner
JAMA | 1992
Milton Hollenberg; Dennis T. Mangano; Warren S. Browner; Martin J. London; Julio F. Tubau; Ida M. Tateo; Jacqueline M. Leung; William C. Krupski; Joseph A. Rapp; Marcus W. Hedgcock; Edward D. Verrier; Scott Merrick; M. Lou Meyer; Linda Levenson; Martin G. Wong; Elizabeth Layug; Juliet Li; Maria E. Franks; Yuriko C. Wellington; Mara Balasubramanian; Evelyn Cembrano; Wilfredo Velasco; Nonato Pineda; Safiullah N. Katiby; Thea Miller; Winifred von Ehrenburg; Brian O'Kelly; Jadwiga Szlachcic; Andrew A. Knight; Virginia Fegert
Anesthesiology | 1992
Dennis T. Mangano; Deanna Siliciano; Milton Hollenberg; Jacqueline M. Leung; Warren S. Browner; Paul Goehner; Scott Merrick; Edward D. Verrier
JAMA | 1992
Mark J. Eisenberg; Martin J. London; Jacqueline M. Leung; Warren S. Browner; Milton Hollenberg; Julio F. Tubau; Ida M. Tateo; Nelson B. Schiller; Dennis T. Mangano; William C. Krupski; Joseph A. Rapp; Marcus W. Hedgcock; Edward D. Verrier; Scott Merrick; M. Lou Meyer; Linda Levenson; Martin G. Wong; Elizabeth Layug; Juliet Li; Maria E. Franks; Yuriko C. Wellington; Mara Balasubramanian; Evelyn Cembrano; Wilfredo Velasco; Nonato Pineda; Safiullah N. Katiby; Thea Miller; Winifred von Ehrenburg; Brian O'Kelly; Jadwiga Szlachcic
JAMA | 1992
Brian O'Kelly; Warren S. Browner; Barry M. Massie; Julio F. Tubau; Long Ngo; Dennis T. Mangano; Martin J. London; Milton Hollenberg; Jacqueline M. Leung; William C. Krupski; Joseph A. Rapp; Marcus W. Hedgcock; Edward D. Verrier; Scott Merrick; M. Lou Meyer; Linda Levenson; Martin G. Wong; Elizabeth Layug; Juliet Li; Maria E. Franks; Yuriko C. Wellington; Mara Balasubramanian; Evelyn Cembrano; Wilfredo Velasco; Nonato Pineda; Safiullah N. Katiby; Diane Beatty; Winifred von Ehrenburg; O'Kelly B; Jadwiga Szlachcic
Anesthesiology | 1992
Dennis T. Mangano; Deanna Siliciano; Milton Hollenberg; Jacqueline M. Leung; Warren S. Browner; Paul Goehner; Scott Merrick; Edward D. Verrier
Anesthesiology | 1991
Jacqueline M. Leung; Paul Goehner; Brian O'Kelly; Milton Hollenberg; Nito Pineda; Brian A. Cason; Dennis T. Mangano
Anesthesiology | 1988
Paul Goehner; Milton Hollenberg; Jacqueline M. Leung; Warren S. Browner; Brian A. Cason; Dennis T. Mangano
Anesthesiology | 1989
Deanna Siliciano; Milton Hollenberg; Paul Goehner; Dennis T. Mangano