Paul Haberfield

The entropy of hydration and the anesthetic effectiveness of saligenins

19881025The anesthetic efficiencies of seven hydroxybenzyl alcohols were found to correlate well with their entropies of hydration. The correlation with lipid solubility was poor. This is taken to mean that the site of activity of these aspirin-like substances is in the aqueous phase and that their mode of action may involve their water-ordering capacity.

Phototropic molecules. 3. Complexation between alkali metal ions andtrans- andcis p,p′-bis(polyether) azobenzenes

Three polyether complexing agents were prepared whose shapes could be photochemically altered by means of an azobenzene fragment incorporated into the middle of the polyether chain. The compounds are 1, bis-4,4′-[2-(methoxyethoxy)acetamido]azobenzene,2, bis-4,4′-[2-(1,3-dimethoxy-2-propoxy)acetamido]azobenzene and3,bis-4,4′-{2-[2-(2-methoxyethoxy)ethoxy]acetamido}azobenzene. Extraction equilibrium constants,KEXT, for the extraction of Li+, Na+ K+, and Cs+ ions from water into an organic solvent were measured for these three agents under irradiation and in the dark. Compounds1 and2 were found to give substantially larger KExT values on irradiation than in the dark. TheK(light)/K(dark) ratios for the three compounds ranged from 0.47 to 16.6.