Paul J. Benkeser

A Tapered Phased Array Ultrasound Transducer for Hyperthermia Treatment

Abstracl-An ultrasonic tapered phased array transducer, consisting of a linear phased array employing elements with a tapered thickness, was developed to study the feasibility of its use for hyperthermic treatment of deep-seated tumors. The cylindrical focal region is generated and steered in two dimensions by controlling the phases of the driving signals on each element and moved in the third dimension by changing the driving frequency. Experimentally obtained field intensity distributions are in good agreement with theoretical predictions. Acoustical power output measurements indicate that tapered phased arrays are capable of providing the intensities necessary for producing therapeutic temperatures in tumors.

Cardiac segmentation by a velocity-aided active contour model

Heart disease is one of the more life-threatening diseases. Accurate diagnosis and treatment are central to the survival of patients. Numerous diagnostic methods that can assess abnormalities of the heart have been developed. Among these methods, cardiac functional analysis has been widely used to derive cardiac functional parameters that describe the functionality of the heart and are frequently used in diagnosis of various heart diseases. Segmentation of the myocardial boundaries is an essential step for deriving these cardiac functional parameters, and the accuracy of parameters depends much on the correctness of the segmented boundaries. Therefore, it is essential that cardiac segmentation be accurate and reliable. However, current segmentation techniques still have difficulty both extracting accurate myocardial boundaries, especially the endocardial boundary and performing a fully automatic process because of low image quality, the complex shape and motion pattern of the heart, and lack of clear delineation between the myocardium and adjacent anatomic structures. A velocity-aided cardiac segmentation method based a modified active contour model, the tensor-based orientation gradient force (OGF) and phase contrast magnetic resonance imaging (MRI) has been developed to improve the accuracy of segmentation of the myocardial boundaries, especially the endocardial boundary. Furthermore, the initial seed contour tracking (SCT) algorithm has been also developed to improve the accuracy of automatic sequential frame segmentation in conjunction with the OGF-based segmentation method. The performance of the proposed method was assessed by experimentations on a phase contrast MRI data set of three normal human volunteer. The results of the individual frame segmentation showed that the accuracy and reproducibility of segmentation of the endocardial boundary by the use of the OGF was generally improved around the lower level of the LV and end systole. The results of the sequential frame segmentation showed that the propagation of errors caused was significantly reduced by the use of the SCT in addition to the OGF and improvements in the accuracy and reproducibility of segmentation of the endocardial boundary were much higher than the individual frame segmentation. However, improvements were generally negligible around the upper level of the LV and end diastole, and the velocity wrap-around problem and blood turbulence around the basal level of the ventricles even degraded the performance of boundary segmentation. Although this work demonstrates the potential of using the velocity information from phase contrast MRI for cardiac segmentation, the velocity wrap-around artifacts in phase contrast MRI data sets can degrade the performance. Therefore, future work must include the development of appropriate methods to cope with these artifacts.

Comparison of septal defects in 2D and 3D echocardiography using active contour models

Three-dimensional ultrasound is emerging as a viable resource for the imaging of internal organs. Quantitative studies correlating ultrasonic volume measurements with MRI data continue to validate this modality as a more efficient alternative for 3D imaging studies. However, the processing required to form 3D images from a set of 2D images may result in a loss of spatial resolution and may give rise to artifacts. This paper examines a method of automatic feature extraction and data quantification in 3D data sets as compared with original 2D data. This work will implement an active contour algorithm to automatically extract the endocardial borders of septal defects in echocardiographic images, and compare the size of the defects in the original 2D images and the 3D data sets.

Analysis of a multielement ultrasound hyperthermia applicator

An unfocused multielement ultrasound applicator was developed for hyperthermia treatment of superficial tumors. The applicator contains sixteen 3.8-cm/sup 2/ individually controllable elements on a 15.2-cm/sup 2/ piezoelectric ceramic plate. The acoustical power output of each element can be independently applied to facilitate uniform heating throughout the treatment area while minimizing undesired heating in normal tissues. The performance of the applicator was examined by measuring acoustical power output and beam profiles. The results of this analysis indicated that the applicator is capable of producing required therapeutic output levels with excellent localization and control of the power deposition.<<ETX>>

A computer-based statistical pattern recognition for Doppler spectral waveforms of intracranial blood flow

A computer-based statistical pattern recognition system has been developed for the analysis of transcranial Doppler (TCD) spectral waveforms of the intracranial middle cerebral artery with varying degrees of increased intracranial pressure. This system extracts multidimensional features from TCD waveforms and performs a cluster analysis of those features. The system can automatically recognize the pattern of spectral waveform and classify it as a normal, abnormal, or borderline subclass of TCD spectral waveform. An optimum decision function was generated based on the Bayes Gaussian classifier. The accuracy of the Bayes Gaussian model the spectral waveforms reaches 100% by estimating posterior probability and using the resubstituting method of estimating misclassification in the training TCD data.

Elastically deformable model-based motion-tracking of left ventricle

The motion of the myocardium is a sensitive indicator of many types of heart disease. Quantitative characterization of this motion is essential for the accurate diagnosis and treatment of heart disease. Although several magnetic resonance imaging (MRI) techniques, such as tagged MRI and phase contrast MRI, provide noninvasive tools to obtain correlation of the position of points within the myocardium between images taken at subsequent time phases, the accurate tracking of the movement of these points remains a challenge due to the relatively low out-of-plane resolution of these imaging techniques. A motion tracking method based on elastic deformation estimation of a deformable model has been developed to track the three-dimensional motion of the myocardium. Elastic deformation estimation is performed on phase contrast MRI data by balancing the deformation potential energy of a deformable model and the potential energy derived from integrating velocity values of myocardial tissue points. The advantage of this method is that it can provide a physically plausible yet computationally efficient framework for cardiac motion tracking. To assess the proposed method, the motion of a normal human left ventricle (LV) was tracked throughout the entire cardiac cycle, and a quantitative strain analysis of the motion of the LV was carried out from end diastole to end systole. The results showed that the strain measurements were generally found to be consistent with previously published values.

A perfused tissue phantom for ultrasound hyperthermia

In this investigation, the phantom, consisting of a fixed porcine kidney with thermocouples placed throughout the tissue, was perfused with degassed water by a variable flow rate pump. The phantom was insonated by an unfocused multielement ultrasound applicator, and the temperatures in the phantom were recorded. The results indicate that for testing protocols where tissue phantoms are needed, the fixed kidney preparation offers an opportunity to use a more realistic phantom than has previously been available to assess the heating performance of ultrasound hyperthermia applicators.<<ETX>>

Sound field calculations for an ultrasonic linear phased array with a spherical liquid lens

Lenses are often used to provide focusing in the elevation dimension of ultrasonic linear phased-array transducers. The use of a liquid lens in this application adds a variable geometric focusing capability, determined by the radius of curvature of the lens surface and speed of sound in the liquid, to the electronic focusing produced by the linear phased array. An efficient method to calculate the sound field radiated from the linear phased-array transducer through the liquid lens is presented. It treats the lens surface as a secondary source distribution according to Huygenss principle, and employs a modified form of the rectangular radiator method to calculate the field. The appropriate phases for the array elements to focus and steer the beam are calculated by considering the refraction on the lens surface. Comparisons of computer simulations and experimental measurements of the field intensity distribution of a prototype linear array transducer with a liquid lens demonstrate the accuracy of the proposed method.<<ETX>>

Computationally efficient sound field calculations for a circular array transducer

A computationally efficient method is presented for calculating field pressure distributions from a circular phased array transducer. This method employs a form of the rectangular radiator approach modified for use with the geometry of a circular array. The curved surface of the elements, radiating either continuous wave or pulsed excitation signals, is divided into incremental rectangular areas small enough so that the Fraunhofer approximation can be applied. Once the directivity of a single element is found, the array beam pattern can be calculated using superposition and suitable coordinate transformations. The validity of this approach is verified through comparisons with experimental data from a circular phased array. The results show that the location and amplitude of the grating lobes and main lobe width can be predicted with reasonable accuracy by using this method.<<ETX>>

Ultrasonic phased arrays with variable geometric focusing for hyperthermia applications

An ultrasonic applicator, which utilizes both electronic and variable geometric focusing, for deep-localized hyperthermia is investigated. The applicator is based around a linear phased array that furnishes its electronic focusing capability. The output of the array radiates through a spherical liquid-lens that provides the applicator a variable geometric focusing capability as well. A lens of this type adds dynamic focusing to the elevation dimension of the linear phased array. By controlling the volume of liquid in the lens (and thus the radius of curvature of its membrane), dynamic control of the geometrical focus can be achieved. Comparisons of computer simulations and experimental measurements of the field intensity distribution of a small-scale prototype applicator are presented. Important design parameters, such as the choice of the liquid for the lens and the size and number of array elements, are examined.<<ETX>>