Paul J. Boisvert

The Dick Test in Military Personnel with special reference to the Pathogenesis of the Skin Reaction.

THE Dick skin test has been widely used for the detection of human beings susceptible to scarlet fever and has proved to be useful for this purpose. It has been demonstrated that a skin rash rarely...

Streptococcal fibrinolysin (streptokinase): A study of this substance and its antibody in group A hemolytic streptococcus sore throat

Abstract 1.1. A large number of group A hemolytic streptococcal respiratory infections in young men have been studied. 2.2. No relationship was discovered between any clinical feature of the disease or its complications and the ability of the infecting hemolytic streptococcus to form fibrinolysin in vitro. 3.3. The serum concentration of antifibrinolysin was low in 90 per cent of the subjects at the onset of their infection. 4.4. An increase in antibody of significant magnitude had occurred in 35 per cent of these patients by the fourth week after the onset of acute respiratory illness. 5.5. An antibody response occurred more frequently when the respiratory disease was severe or when a suppurative or nonsuppurative complication supervened.

Sulfonamide and penicillin resistance of group A hemolytic streptococci.

Summary Strains of certain types of Group A hemolytic streptococci were discovered to be naturally resistant to moderate amounts of sulfadiazine. It is suggested that such organisms originated the epidemics of streptococcal disease among troops receiving sulfonamide prophylaxis, later becoming more resistant by mutation. No strains significantly resistant to penicillin were discovered.

Streptococcal fibrinolysin (streptokinase)

Abstract 1.1. A large number of group A hemolytic streptococcal respiratory infections in young men have been studied. 2.2. No relationship was discovered between any clinical feature of the disease or its complications and the ability of the infecting hemolytic streptococcus to form fibrinolysin in vitro. 3.3. The serum concentration of antifibrinolysin was low in 90 per cent of the subjects at the onset of their infection. 4.4. An increase in antibody of significant magnitude had occurred in 35 per cent of these patients by the fourth week after the onset of acute respiratory illness. 5.5. An antibody response occurred more frequently when the respiratory disease was severe or when a suppurative or nonsuppurative complication supervened.