Paul J. Dyson

[Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

The water soluble complex n[Ru(η6-p-cymene)Cl2(pta)] (pta = n1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA ndamage; the pH at which damage is greatest correlates well to the pH nenvironment of cancer cells.

Transition metal chemistry in ionic liquids

Transition metal chemistry in ionic liquids has increased dramatically in the last few years. Ionic liquids can be used to prepare transition metal complexes and clusters. They can be used to carry out stoichiometric reactions on ligands attached to transition metal ions, and they can also be used to support transition metal catalysts. Ionic liquids composed of organic cations and transition metal anions are also known. Each of these areas will be discussed in this article.

Energy-dependent electrospray ionisation mass spectrometry: applications in transition metal carbonyl chemistry

Maps of electrospray mass spectrometry data, plotted as cone voltage versus mass-to-charge ratio, provide a clear and compact method of visualising the accompanying fragmentation processes, in this case applied to the sequential removal of ligands from transition-metal carbonyl complexes. The technique is described as energy-dependent electrospray ionisation mass spectrometry (EDESI-MS). Copyright 2000 John Wiley & Sons, Ltd.

The Interactions of Low Oxidation State Transition Metal Clusters with DNA: Potential Applications in Cancer Therapy

A series of ruthenium and platinum clusters have been examined for DNA binding activity in methanol-water and water solutions. The clusters [H4Ru4(C6H6)4]2+and Ru3(CO)9(PTA)3(PTA=1,3,5-triaza-7-phosphatricyclo[3.3.1.1] decane) proved to be most effective; the former is believed to cross link DNA and the latter possibly intercalates. These clusters are highly water soluble and combined with their DNA damaging activity and size represent potential anticancer drugs.

Hydrogenation of non-activated alkenes catalysed by water-soluble ruthenium carbonyl clusters using a biphasic protocol

Abstract The use of the water soluble ruthenium clusters Ru 3 (CO) 12− x (TPPTN) x ( x =1 1 , 2 2 or 3 3 ) and H 4 Ru 4 (CO) 11 (TPPTN) 4 (TPPTN=P{ m -C 6 H 4 SO 3 Na) 3 ) as catalyst precursors in the hydrogenation of non-activated alkenes under biphasic conditions is described. Each cluster displays activity under moderate conditions, ca. 60 atm. H 2 at 60°C, with catalytic turnovers up to ca. 500. The trinuclear clusters undergo transformation during reaction but can be reused repeatedly without loss of activity. Other methodologies such as ionic liquid–organic and the use of silica supports have been attempted with these clusters but they are less effective than the aqueous–organic regime.

Chloroaluminate(III) ionic liquid mediated synthesis of transition metal–cyclophane; complexes: their role as solvent and Lewis acid catalyst

Abstract The preparation of transition metal–cyclophane complexes using the ionic liquid system [bmim]Cl–AlCl 3 ([bmim] + =1-butyl-3-methylimidazolium cation) as both the solvent and Lewis acid catalyst is described. Both known and novel complexes are prepared. Simple arene complexes of manganese have also been prepared in order to demonstrate the chemistry and these reactions are compared with the literature preparations conducted in conventional organic solvents.

Electrospray mass spectrometry of metal carbonyl complexes

Methods are described for characterising neutral metal carbonyl complexes using electrospray mass spectrometry, by converting them into ions with suitable reagents. Ionisation techniques included addition of OMe– generating [Mxa0+xa0OMe]– species, addition of Ag+ or Na+ ions giving the appropriate positive ion, abstraction of acidic hydrogen forming [Mxa0–xa0H]– ions, or (in rare cases) oxidation giving radical cations [M]˙+. The methods can be used on pure compounds or on mixtures. Fragmentation in the mass spectrometer can be minimised so that identification of parent species is unambiguous. Applications are demonstrated with a wide range of compounds including mononuclear and polynuclear binary carbonyls, and with derivatives containing phosphine, cyclopentadienyl, π-arene, σ-aryl and other ligands.

Ruthenium cluster–[2.2]paracyclophane complexes

Abstract The last few years have seen a rapid expansion in the synthesis and characterisation of cluster–arene complexes. One arene ligand which has been found to be particularly versatile in cluster chemistry is [2.2]paracyclophane. In this article we review the chemistry of [2.2]paracyclophane clusters with regard to their synthesis, reactivity and structure.

1-butyl-3-methylimidazolium cobalt tetracarbonyl [bmim][Co(CO)4]: a catalytically active organometallic ionic liquid.

An ambient temperature liquid transition metal carbonyl anion has been prepared in a metathesis reaction between [bmim]Cl ([bmim]+ = 1-butyl-3-methylimidazolium cation) and Na[Co(CO)4]; the ionic liquid catalyses the debromination of 2-bromoketones.

Tetravalent Tellurium Ligands

Oxidative addition of TeCl4 to Vaskas complex gave the trichlorotelluronium complex [IrCl2 (TeCl3 )(CO)(PPh3 )2 ] (structure depicted), which contains a rare example of a structurally characterized tetravalent tellurium ligand. The coordination at the TeIV center is-in full agreement with the VSEPR model-distorted trigonal bipyramidal.