Paul L. Schiff

Trigilletine and tricordatine: Two new bisbenzylisoquinoline alkaloids from Triclisia species

Abstract Trigilletine and tricordatine, two new alkaloids from Ghanian menispermaceous species, have structures Ib and Ic, respectively and are examples of phenolic isotrilobine-type (Ia) alkaloids from higher plants.

Pachyovatamine, a bisbenzylisoquinoline alkaloid, and other alkaloids from Pachygone ovata

Abstract A new dibenzo- p -dioxin biphenyl bisbenzylisoquinoline alkaloid, pachyovatamine, has been isolated from an extract of the leaves and stems of Pachygone ovata from Sri Lanka. The alkaloid was characterized by a consideration of its physicochemical data and conversion to O -acetyltiliacorinine. Pachygonamine, N -methylpachygonamine and tiliamosine were also isolated from the same extract.

Alkaloids of Jordanian Thalictrum isopyroides

Abstract The isolation and identification of 12 alkaloids from an extract of the roots of Thalictrum isopyroides is described. The alkaloids isolated are the aporphines ocoteine (thalicmine), thaliporphine, preocoteine, N -methyllaurotetanine, delporphine, isoboldine, N -methylcassythine and magnoflorine, the dehydroaporphine, dehydroocoteine, the oxoaporphine, thalicminine, and the bisbenzylisoquinolines, thaligosinine and thalisopidine.

Quaternary alkaloids of Thalictrum cultratum

Abstract The isolation and identification of seven alkaloids from the quaternary alkaloid fraction of a root extract of Thalictrum cultratum are described.

Chapter One The thalictrum alkaloids: Chemistry and Pharmacology (1985-1995)

Publisher Summary This chapter discusses the chemistry and pharmacology of the thalictrum alkaloids. Many of these alkaloids have interesting and important pharmacological properties, and a plethora of studies involving the biological evaluation of these compounds have been undertaken and published. The purpose of this work is to review the research that has been published in the last decade. This chapter summarizes the isolation and identification of the alkaloids of Thalictrum cultratum Wall. The plant was collected in Azad Kashmir, Pakistan, and extracts of the whole plant proved to be a uniquely prolific source of benzylisoquinoline-derived alkaloids, including monomers of the aporphine, pavine, phenanthrene, and protoberberine groups, and dimers of the bisbenzylisoquinoline, secobisbenzylisoquinoline, and aporphine-benzylisoquinoline groups. Eighteen bisbenzylisoquinoline alkaloids were isolated, with these compounds belonging to the thalisopine, thalicberine, thalidasine, and thalmine series.