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Paul R. Kelbaugh

Pfizer

Publication

Featured researches published by Paul R. Kelbaugh.

Tetrahedron Letters | 1988

The total synthesis of argiotoxins 636, 659 and 673

V. John Jasys; Paul R. Kelbaugh; Deane M. Nason; Douglas Phillips; Nicholas Alex Saccomano; Robert A. Volkmann

Practical syntheses of three polyamine spider toxins isolated from the venom of Argiope aurantia are described.

Tetrahedron Letters | 1989

Synthesis of neurotoxic nephila spider venoms: NSTX-3 and JSTX-3

Deane M. Nason; Vytautus John Jasys; Paul R. Kelbaugh; Douglas Phillips; Nicholas Alex Saccomano; Robert A. Volkmann

Abstract Efficient and practical synthetic routes to the polyamine spider venom principles, NSTX-3 and JSTX-3 are described.

Molecular Pharmacology | 1997

Heteropodatoxins: Peptides Isolated from Spider Venom that Block Kv4.2 Potassium Channels

Michael C. Sanguinetti; Janice H. Johnson; Lance G. Hammerland; Paul R. Kelbaugh; Robert A. Volkmann; Nicholas Alex Saccomano; Alan L. Mueller

Journal of the American Chemical Society | 1990

Isolation, structure elucidation, and synthesis of novel hydroxylamine-containing polyamines from the venom of the Agelenopsis aperta spider

V. J. Jasys; Paul R. Kelbaugh; D. M. Nason; D. Phillips; K. J. Rosnack; Nicholas Alex Saccomano; Justin G. Stroh; Robert A. Volkmann

Journal of Organic Chemistry | 1992

2-Thioalkyl penems: an efficient synthesis of sulopenem, a (5R,6S)-6-(1(R)-hydroxyethyl)-2-[(cis-1-oxo-3-thiolanyl)thio]-2-penem antibacterial

Robert A. Volkmann; Paul R. Kelbaugh; Deane M. Nason; V. John Jasys

Journal of Organic Chemistry | 1982

Synthesis of optically active spirohydantoins by asymmetric induction. Hydantoin formation from amino nitriles and chlorosulfonyl isocyanates

Reinhard Sarges; Harry Ralph Howard; Paul R. Kelbaugh

Journal of the American Chemical Society | 1994

Disulfide Bond Assignment of .omega.-Agatoxins IVB and IVC: Discovery of a D-Serine Residue in .omega.-Agatoxin IVB

Steven D. Heck; Paul R. Kelbaugh; Mary E. Kelly; Peter F. Thadeio; Nicholas Alex Saccomano; Justin G. Stroh; Robert A. Volkmann

Journal of Organic Chemistry | 1992

Novel quaternary ammonium salt-containing polyamines from the Agelenopsis aperta funnel-web spider

V. John Jasys; Paul R. Kelbaugh; Deane M. Nason; Douglas Phillips; Kenneth J. Rosnack; Nicholas Alex Saccomano; Justin G. Stroh; Robert A. Volkmann; James T. Forman

Journal of Medicinal Chemistry | 1989

Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors

James P. Rizzi; Rodney C. Schnur; Nancy J. Hutson; Kenneth G. Kraus; Paul R. Kelbaugh

The Journal of Antibiotics | 1990

Pharmacokinetic studies in animals of a new parenteral penem CP-65,207 and its oral prodrug ester.

Thomas D. Gootz; Dennis Girard; William Schelkley; Thomas G. Tensfeldt; George Foulds; Michael S. Kellogg; John G. Stam; Benedict Campbell; John Jasys; Paul R. Kelbaugh; Robert A. Volkmann; Ernest Seiichi Hamanaka

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