Paul S. Jellinger
University of Miami
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Endocrine Practice | 2009
Helena W. Rodbard; Paul S. Jellinger; Jaime A. Davidson; Daniel Einhorn; Alan J. Garber; George Grunberger; Yehuda Handelsman; Edward S. Horton; Harold E. Lebovitz; Philip Levy; Etie S. Moghissi; Stanley Schwartz
This report presents an algorithm to assist primary care physicians, endocrinologists, and others in the management of adult, nonpregnant patients with type 2 diabetes mellitus. In order to minimize the risk of diabetes-related complications, the goal of therapy is to achieve a hemoglobin A1c (A1C) of 6.5% or less, with recognition of the need for individualization to minimize the risks of hypoglycemia. We provide therapeutic pathways stratified on the basis of current levels of A1C, whether the patient is receiving treatment or is drug naïve. We consider monotherapy, dual therapy, and triple therapy, including 8 major classes of medications (biguanides, dipeptidyl-peptidase-4 inhibitors, incretin mimetics, thiazolidinediones, alpha-glucosidase inhibitors, sulfonylureas, meglitinides, and bile acid sequestrants) and insulin therapy (basal, premixed, and multiple daily injections), with or without orally administered medications. We prioritize choices of medications according to safety, risk of hypoglycemia, efficacy, simplicity, anticipated degree of patient adherence, and cost of medications. We recommend only combinations of medications approved by the US Food and Drug Administration that provide complementary mechanisms of action. It is essential to monitor therapy with A1C and self-monitoring of blood glucose and to adjust or advance therapy frequently (every 2 to 3 months) if the appropriate goal for each patient has not been achieved. We provide a flow-chart and table summarizing the major considerations. This algorithm represents a consensus of 14 highly experienced clinicians, clinical researchers, practitioners, and academicians and is based on the American Association of Clinical Endocrinologists/American College of Endocrinology Diabetes Guidelines and the recent medical literature.
Endocrine Practice | 2007
Helena W. Rodbard; Lawrence Blonde; Susan S. Braithwaite; Elise M. Brett; Rhoda H. Cobin; Yehuda Handelsman; Richard Hellman; Paul S. Jellinger; Lois Jovanovic; Philip Levy; Jeffrey I. Mechanick; Farhad Zangeneh
Acknowledgments We would like to recognize Elliot Sternthal, MD, FACE, and Joseph Vassalotti, MD, for their review of these guidelines and thoughtful comments.
Endocrine Practice | 2016
Alan J. Garber; Martin J. Abrahamson; Joshua I. Barzilay; Lawrence Blonde; Zachary T. Bloomgarden; Michael A. Bush; Samuel Dagogo-Jack; Ralph A. DeFronzo; Daniel Einhorn; Vivian Fonseca; Jeffrey R. Garber; W. Timothy Garvey; George Grunberger; Yehuda Handelsman; Robert R. Henry; Irl B. Hirsch; Paul S. Jellinger; Janet B. McGill; Jeffrey I. Mechanick; Paul D. Rosenblit; Guillermo E. Umpierrez
Abbreviations: A1C = hemoglobin A1C AACE = American Association of Clinical Endocrinologists ACCORD = Action to Control Cardiovascular Risk in Diabetes ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure ACEI = angiotensinconverting enzyme inhibitor AGI = alpha-glucosidase inhibitor apo B = apolipoprotein B ARB = angiotensin II receptor blocker ASCVD = atherosclerotic cardiovascular disease BAS = bile acid sequestrant BMI = body mass index BP = blood pressure CHD = coronary heart disease CKD = chronic kidney disease CVD = cardiovascular disease DKA = diabetic ketoacidosis DPP-4 = dipeptidyl peptidase 4 EPA = eicosapentaenoic acid FDA = Food and Drug Administration GLP-1 = glucagon-like peptide 1 HDL-C = high-density-lipoprotein cholesterol LDL-C = low-densitylipoprotein cholesterol LDL-P = low-density-lipoprotein particle Look AHEAD = Look Action for Health in Diabetes NPH = neutral protamine Hagedorn OSA = obstructive sleep apnea SFU = sulfonylurea SGLT-2 = sodium glucose cotrans...
Endocrine Practice | 2012
Paul S. Jellinger; Smith Da; Adi E. Mehta; Om P. Ganda; Yehuda Handelsman; Helena W. Rodbard; Mark D. Shepherd; John A. Seibel
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice are systematically developed statements to assist health care professionals in medical decision-making for specific clinical conditions, but are in no way a substitute for a medical professional’s independent judgment and should not be considered medical advice. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with, and not as a replacement for, their best clinical judgment. The presented recommendations may not be appropriate in all situations. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances.
Endocrine Practice | 2013
Alan M. Garber; Martin J. Abrahamson; Joshua I. Barzilay; Lawrence Blonde; Zachary T. Bloomgarden; Michael A. Bush; Samuel Dagogo-Jack; Michael Davidson; Daniel Einhorn; W. Garvey; George Grunberger; Yehuda Handelsman; Irl B. Hirsch; Paul S. Jellinger; Janet B. McGill; Jeffrey I. Mechanick; Paul D. Rosenblit; Guillermo E. Umpierrez
Alan J. Garber, MD, PhD, FACE; Martin J. Abrahamson, MD; Joshua I. Barzilay, MD, FACE; Lawrence Blonde, MD, FACP, FACE; Zachary T. Bloomgarden, MD, MACE; Michael A. Bush, MD; Samuel Dagogo-Jack, MD, FACE; Michael B. Davidson, DO, FACE; Daniel Einhorn, MD, FACP, FACE; W. Timothy Garvey, MD; George Grunberger, MD, FACP, FACE; Yehuda Handelsman, MD, FACP, FACE, FNLA; Irl B. Hirsch, MD; Paul S. Jellinger, MD, MACE; Janet B. McGill, MD, FACE; Jeffrey I. Mechanick, MD, FACE, ECNU, FACN, FACP; Paul D. Rosenblit, MD, PhD, FACE, FNLA; Guillermo E. Umpierrez, MD, FACE; Michael H. Davidson, MD, FACC, FACP, FNLA
Endocrine Practice | 2015
Yehuda Handelsman; Zachary T. Bloomgarden; George Grunberger; Guillermo Umpierrez; Robert S. Zimmerman; Timothy S. Bailey; Lawrence Blonde; George A. Bray; A. Jay Cohen; Samuel Dagogo-Jack; Jaime A. Davidson; Daniel Einhorn; Om P. Ganda; Alan J. Garber; W. Timothy Garvey; Robert R. Henry; Irl B. Hirsch; Edward S. Horton; Daniel L. Hurley; Paul S. Jellinger; Lois Jovanovič; Harold E. Lebovitz; Derek LeRoith; Philip Levy; Janet B. McGill; Jeffrey I. Mechanick; Jorge H. Mestman; Etie S. Moghissi; Eric A. Orzeck; Rachel Pessah-Pollack
The American Association of Clinical Endocrinologists/American College of Endocrinology Medical Guidelines for Clinical Practice are systematically developed statements to assist healthcare professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with their best clinical judgment. The presented recommendations may not be appropriate in all situations. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances. Abbreviations: A1C = hemoglobin A1c AACE = American Association of Clinical Endocrinologists ACCORD = Action to Control Cardiovascu...
Endocrine Practice | 2008
Alan J. Garber; Yehuda Handelsman; Daniel Einhorn; Donald Bergman; Zachary T. Bloomgarden; Vivian Fonseca; W. Timothy Garvey; James R. Gavin; George Grunberger; Edward S. Horton; Paul S. Jellinger; Kenneth L. Jones; Harold E. Lebovitz; Philip Levy; Darren K. McGuire; Etie S. Moghissi; Richard W. Nesto
Alan J. Garber, MD, PhD, FACE, Yehuda Handelsman, MD, FACP, FACE, Daniel Einhorn, MD, FACP, FACE, Donald A. Bergman, MD, FACE, Zachary T. Bloomgarden, MD, FACE, Vivian Fonseca, MD, FACE, W. Timothy Garvey, MD, James R. Gavin III, MD, PhD, George Grunberger, MD, FACP, FACE, Edward S. Horton, MD, FACE, Paul S. Jellinger, MD, MACE, Kenneth L. Jones, MD, Harold Lebovitz, MD, FACE, Philip Levy, MD, MACE, Darren K. McGuire, MD, MHSc, FACC, Etie S. Moghissi, MD, FACP, FACE, and Richard W. Nesto, MD, FACC, FAHA
Endocrine Practice | 2013
Alan M. Garber; Martin J. Abrahamson; Joshua I. Barzilay; Lawrence Blonde; Zachary T. Bloomgarden; Michael A. Bush; Samuel Dagogo-Jack; Michael Davidson; Daniel Einhorn; W. Garvey; George Grunberger; Yehuda Handelsman; Irl B. Hirsch; Paul S. Jellinger; Janet B. McGill; Jeffrey I. Mechanick; Paul D. Rosenblit; Guillermo E. Umpierrez; Michael Devidson
Alan J. Garber, MD, PhD, FACE; Martin J. Abrahamson, MD; Joshua I. Barzilay, MD, FACE; Lawrence Blonde, MD, FACP, FACE; Zachary T. Bloomgarden, MD, MACE; Michael A. Bush, MD; Samuel Dagogo-Jack, MD, FACE; Michael B. Davidson, DO, FACE; Daniel Einhorn, MD, FACP, FACE; W. Timothy Garvey, MD; George Grunberger, MD, FACP, FACE; Yehuda Handelsman, MD, FACP, FACE, FNLA; Irl B. Hirsch, MD; Paul S. Jellinger, MD, MACE; Janet B. McGill, MD, FACE; Jeffrey I. Mechanick, MD, FACE, ECNU, FACN, FACP; Paul D. Rosenblit, MD, PhD, FACE, FNLA; Guillermo E. Umpierrez, MD, FACE; Michael H. Davidson, MD, FACC, FACP, FNLA
Endocrine Practice | 2015
Alan J. Garber; Martin J. Abrahamson; Joshua I. Barzilay; Lawrence Blonde; Zachary T. Bloomgarden; Michael A. Bush; Samuel Dagogo-Jack; Michael B. Davidson; Daniel Einhorn; Jeffrey R. Garber; W. Timothy Garvey; George Grunberger; Yehuda Handelsman; Irl B. Hirsch; Paul S. Jellinger; Janet B. McGill; Jeffrey I. Mechanick; Paul D. Rosenblit; Guillermo E. Umpierrez; Michael Davidson
George Grunberger, MD, FACP, FACE Yehuda Handelsman, MD, FACP, FNLA, FACE Irl B. Hirsch, MD Paul S. Jellinger, MD, MACE Janet B. McGill, MD, FACE Je rey I. Mechanick, MD, FACP, FACE, FACN, ECNU Paul D. Rosenblit, MD, PhD, FNLA, FACE Guillermo Umpierrez, MD, FACP, FACE Michael H. Davidson, MD, Advisor Martin J. Abrahamson, MD Joshua I. Barzilay, MD, FACE Lawrence Blonde, MD, FACP, FACE Zachary T. Bloomgarden, MD, MACE Michael A. Bush, MD Samuel Dagogo-Jack, MD, DM, FRCP, FACE Michael B. Davidson, DO, FACE Daniel Einhorn, MD, FACP, FACE Je rey R. Garber, MD, FACP, FACE W. Timothy Garvey, MD, FACE TASK FORCE Alan J. Garber, MD, PhD, FACE, Chair AACE/ACE COMPREHENSIVE DIABETES MANAGEMENT ALGORITHM 2015
Endocrine Practice | 2017
Paul S. Jellinger; Yehuda Handelsman; Paul D. Rosenblit; Zachary T. Bloomgarden; Vivian Fonseca; Alan J. Garber; George Grunberger; Chris K. Guerin; David S. H. Bell; Jeffrey I. Mechanick; Rachel Pessah-Pollack; Kathleen Wyne; Smith Da; Eliot A. Brinton; Sergio Fazio; Michael Davidson; Farhad Zangeneh; Michael A. Bush
OBJECTIVE The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS Each Recommendation is based on a diligent review of the clinical evidence with transparent incorporation of subjective factors. RESULTS The Executive Summary of this document contains 87 Recommendations of which 45 are Grade A (51.7%), 18 are Grade B (20.7%), 15 are Grade C (17.2%), and 9 (10.3%) are Grade D. These detailed, evidence-based recommendations allow for nuance-based clinical decision making that addresses multiple aspects of real-world medical care. The evidence base presented in the subsequent Appendix provides relevant supporting information for Executive Summary Recommendations. This update contains 695 citations of which 202 (29.1 %) are evidence level (EL) 1 (strong), 137 (19.7%) are EL 2 (intermediate), 119 (17.1%) are EL 3 (weak), and 237 (34.1%) are EL 4 (no clinical evidence). CONCLUSION This CPG is a practical tool that endocrinologists, other healthcare professionals, regulatory bodies and health-related organizations can use to reduce the risks and consequences of dyslipidemia. It provides guidance on screening, risk assessment, and treatment recommendations for a range of patients with various lipid disorders. These recommendations emphasize the importance of treating low-density lipoprotein cholesterol (LDL-C) in some individuals to lower goals than previously recommended and support the measurement of coronary artery calcium scores and inflammatory markers to help stratify risk. Special consideration is given to patients with diabetes, familial hypercholesterolemia, women, and pediatric patients with dyslipidemia. Both clinical and cost-effectiveness data are provided to support treatment decisions. ABBREVIATIONS A1C = hemoglobin A1C ACE = American College of Endocrinology ACS = acute coronary syndrome AHA = American Heart Association ASCVD = atherosclerotic cardiovascular disease ATP = Adult Treatment Panel apo = apolipoprotein BEL = best evidence level CKD = chronic kidney disease CPG = clinical practice guidelines CVA = cerebrovascular accident EL = evidence level FH = familial hypercholesterolemia HDL-C = high-density lipoprotein cholesterol HeFH = heterozygous familial hypercholesterolemia HIV = human immunodeficiency virus HoFH = homozygous familial hypercholesterolemia hsCRP = high-sensitivity C-reactive protein LDL-C = low-density lipoprotein cholesterol Lp-PLA2 = lipoprotein-associated phospholipase A2 MESA = Multi-Ethnic Study of Atherosclerosis MetS = metabolic syndrome MI = myocardial infarction NCEP = National Cholesterol Education Program PCOS = polycystic ovary syndrome PCSK9 = proprotein convertase subtilisin/kexin type 9 T1DM = type 1 diabetes mellitus T2DM = type 2 diabetes mellitus TG = triglycerides VLDL-C = very low-density lipoprotein cholesterol.