Paul S. Mueller

Fracture Risk After Bariatric Surgery

Both restrictive and malabsorptive bariatric surgeries affect bone remodeling adversely and reduce bone density. In this population-based retrospective cohort study, investigators determined fracture risk in nearly 2100 obese patients who had undergone bariatric …

Poor Adherence to Once-Daily Antihypertensive Drugs Is Common

Poor adherence to antihypertensive drug treatment is a major reason for insufficient blood pressure control. In this longitudinal study, investigators

Statins in Patients with Chronic Kidney Disease

Cardiovascular disease is the leading cause of death among patients with chronic kidney disease (CKD). In the general population and in patients with established cardiovascular disease, statins lower risks for nonfatal cardiovascular events, cardiovascular deaths, and all-cause mortality. Do statins have similar benefits in patients with CKD? …

Increasing BMI Is Associated with Increased Cancer Risk and Mortality in Women

A growing body of evidence indicates that obesity (body-mass index, ≥30 kg/m2) is associated with all-cause mortality, disability, and specific diseases such as coronary artery disease, diabetes, and osteoarthritis. Less is known, however, about the relation between obesity and cancer. U.K. investigators examined the relation between BMI and cancer …

Plasma 25-Hydroxyvitamin D Concentration Is Associated Inversely with Risk for Cancer

Whether plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with cancer risk is unclear. In this Japanese observational study,

Trimethoprim Is Associated with Excess Risk for Acute Kidney Injury in Elders

Trimethoprim/sulfamethoxazole (TMP/SMX) use is associated with excess risk for hyperkalemia and related adverse events in patients who take

Migraine Is Associated with Excess Stroke and Venous Thromboembolism Risk

Prior research has suggested an association between migraine and myocardial infarction and stroke (NEJM JW Gen Med Sep 15 2006 and JAMA 2006; 296:283;

Does Adding Additional Antihypertensive Drugs Result in Progressively Diminished Effects

Observational studies have suggested that the incremental benefits of blood pressure (BP) lowering diminish as the number of antihypertensive drugs

Another Look at Vertebroplasty for Patients with Painful Vertebral Compression Fractures

In previous trials, vertebroplasty for pain relief has not outperformed sham procedures in patients with acute osteoporotic compression fractures

Endovascular vs. Open Repair for Suspected Ruptured Abdominal Aortic Aneurysm

In a previously reported U.K. trial of 613 patients with clinically suspected rupture of abdominal aortic aneurysm (AAA), 30-day mortality and hospital