Paul Saunders

Off-Pump Coronary Artery Bypass Grafting Reduces Mortality and Stroke in Patients With Atheromatous Aortas: A Case Control Study

Background—Patients with severe atheromatous aortic disease (AAD) who undergo coronary artery bypass (CABG) have an increased risk of death and stroke. We hypothesized that in these high risk patients, off-pump coronary artery bypass (OPCAB) technique is associated with lower morbidity and mortality. Methods and Results—Between June 1993 and January 2002, 5737 patients undergoing CABG had routine intra-operative TEE with 913 (15.9%) found to have severe AAD in the aortic arch or ascending aorta. Of these, 211 patients who underwent OPCAB were matched with 211 on-pump CABG patients by age, ejection fraction, history of stroke, cerebrovascular disease, diabetes, renal disease, nonelective operation, and previous cardiac surgery. Hospital mortality was 11.4% (24/211) for on-pump CABG and 3.8% (8/211) for OPCAB (P =0.003). Multivariate analysis revealed that increased mortality was associated with on-pump CABG (P =0.001), acute MI (P =0.03), number of grafts (P =0.01), age (P =0.01), history of stroke or cerebrovascular disease (P =0.04), CHF (P =0.02), and peripheral vascular disease (P =0.03). Multivariate analysis showed that OPCAB technique was associated with decreased stroke (P =0.05). Freedom from any complication was 78.7% for on-pump CABG and 91.9% for OPCAB (P <0.001). At 36 month follow-up multivariate analysis revealed that increased mortality was associated with age (P =0.001), previous MI (P =0.03), and renal disease (P =0.04), whereas increased survival was associated with increased number of grafts (P =0.001) and OPCAB (P =0.01). Conclusions—OPCAB surgery in patients with severe AAD is associated with lower risk of death, stroke and complications and improved mid-term survival. Routine intra-operative TEE allows identification of these patients and directs choice of appropriate surgical technique.

Minimally Invasive Aortic Valve Surgery in the Elderly: A Case-Control Study

Introduction—Although minimally invasive aortic valve surgery (MIAVR) is performed in many centers, few studies have compared its results to a standard sternotomy (SS) approach. We assessed the hypothesis that, when compared with SS in the elderly population, MIAVR has similar morbidity and mortality and allows faster hospital recovery. Methods and Results—From January 1995 through February 2002, 515 patients over age 65 underwent isolated aortic valve replacement. Using data gathered prospectively, 189 MIAVR patients were matched with 189 SS patients by age, ventricular function, valvular pathology, urgency of operation, diabetes, previous cardiac surgery, renal disease, and history of stroke. In each group, 56.1% of patients underwent non-elective procedures, and 28% were ≥80 years old. Hospital mortality (6.9%) and freedom from postoperative morbidity (82.5% versus 81.5%, P =0.79) were similar. Multivariate analysis revealed that urgent procedures [Odds Ratio (OR)=3.97; P =0.03], congestive heart failure (OR=3.94; P =0.03), and ejection fraction <30% (OR=4.16; P =0.03) were significant predictors of hospital mortality. Prolonged length of stay was associated with age (P =0.05), preoperative stroke (OR=3.5, P =0.001), CHF (OR=2.2, P =0.004), and sternotomy approach (OR=2.3, P =0.002) by multivariate analysis. More MIAVR patients were discharged home (52.6% versus 38.6%, P =0.03) rather than to rehabilitation facilities. Three year actuarial survival revealed no difference between groups. Conclusions—Minimally invasive aortic valve surgery is safe in elderly patients, with morbidity and mortality comparable to sternotomy approach. The shorter hospital stay and greater percentage of patients discharged home after MIAVR reflect enhanced recovery with this technique.

Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts

Vein graft failure following bypass surgery is a frequent and important clinical problem. The vascular injury caused by arterialization is responsible for vein graft intimal hyperplasia, a lesion generated by medial smooth muscle cell proliferation and migration into the intima, increased extracellular matrix deposition, and formation of a thick neointima. Development of the neointima into a typical atherosclerotic lesion and consequent stenosis ultimately result in vein graft failure. Endothelial damage, inflammation, and intracellular signaling through mitogenactivated protein kinases (MAPKs) have been implicated in the early stages of this process. We therefore investigated the effects of topical inhibition of ERK‐1/2 MAPK activation on vascular cell proliferation and apoptosis, and on the inflammatory response in a canine model of vein graft arterialization. For this purpose, vein grafts were incubated with the MEK‐1/2 inhibitor, UO126, ex vivo for 30 min before grafting. This treatment effectively abolished arterializationinduced ERK‐1/2 activation, decreased medial cell proliferation, and increased apoptosis. UO126 treatment also inhibited the vein graft infiltration by myeloperoxidase‐positive inflammatory cells that follows vein graft arterialization. Thus, topical ex vivo administration of MAPK inhibitors can provide a pharmacological tool to prevent or reduce the vascular cell responses that lead to vein graft intimal hyperplasia and graft failure.

Medication-induced Takotsubo Cardiomyopathy presenting with cardiogenic shock—utility of extracorporeal membrane oxygenation (ECMO): case report and review of the literature

Takotsubo cardiomyopathy (TTC) is a transient condition that affects the myocardium and is seen mostly in post-menopausal women secondary to an emotional or physical stressor; however, certain drugs have been described as cause of this syndrome. We report the case of a young female with medication--induced TTC, who presented with cardiogenic shock as initial manifestation, treated successfully with extracorporeal membrane oxygenation (ECMO). To our knowledge, this is the first case in the literature describing the use of ECMO in cardiogenic shock due to medication-induced TTC.

National Landscape of Unplanned 30-Day Readmissions in Patients with Left Ventricular Assist Device Implantation

The number of patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation has increased dramatically over the last decade. There are limited data available about the nationwide trends of complications leading to readmissions after implantation of contemporary devices. Patients who underwent LVAD implantation from January 2013 to December 2013 were identified using International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) code 37.66 from the Healthcare Cost and Utilization Projects National Readmission Database. The top causes of unplanned 30-day readmission after LVAD implantation were determined. Survey logistic regression was used to analyze the significant predictors of readmission. In 2013, there were 2,235 patients with an LVAD implantation. Of them, 665 (29.7%) had at least 1 unplanned readmission within 30 days, out of which 289 (43.4%) occurred within 10 days after discharge. Implant complications (14.9%), congestive heart failure (11.7%), and gastrointestinal bleeding (8.4%) were the top 3 diagnoses for the first readmission and accounted for more than a third of all readmissions. Significant predictors of readmissions included a prolonged length of stay during the index admission, Medicare insurance, and discharge to short-term facility. In conclusion, despite increased experience with LVADs, unplanned readmissions within 30 days of implantation remain significantly high.

GERIATRIC ASSESSMENT TOOLS AND OUTCOME PREDICTION IN TRANSCATHETER AORTIC VALVE REPLACEMENT

Background: Aortic stenosis (AS) is a common heart valve disease in the elderly. The selection for transcatheter aortic valve replacement (TAVR) is difficult because many elderly patients have multiple co-morbidities. Current global risk scores including the STS score and the EuroSCORE may be

Common carotid artery pseudoaneurysm secondary to Mycobacterium tuberculosis treated with resection and reconstruction with saphenous vein graft

Extracranial carotid artery aneurysms secondary to Mycobacterium tuberculosis infection are exceedingly rare. Despite an uncommon location and offending pathogen, the treatment paradigm follows that of all mycotic aneurysms. We report the case of a right common carotid artery pseudoaneurysm caused by a tuberculous infection, successfully treated with antibiotics, resection, and autologous interposition graft.

Contralateral embolization of intima after transfemoral aortic valve replacement.

An 88-year-old woman with a history of breast cancer and aortic stenosis presented with heart failure. Echocardiogram showed severe aortic stenosis and valve area of 0.5 cm2. Due to her comorbidities, she was deemed to be at high risk for valve surgery and was evaluated for transcatheter aortic