Paul Spevak

Reductive Cleavage of Symmetrical Disulfides with Hydrazines

Abstract An efficient method for the reductive cleavage of symmetrical disulfides with hydrazines is described.

Alkaline Earth Metal Mediated Reduction of Azides to Amines

Abstract A mild and facile method for the reduction of alkyl and aryl azides to the corresponding amines using alkaline earth metals is described.

Synthesis of 7α-methoxy-2-(1,3-dithiolan-2-ylidene)cephem sulphones. A new series of human leukocyte elastase inhibitors

Abstract Treatment of 3-methyl-3-cephem sulphone with sodium hydride followed by carbon disulphide and alkyl halide provides an entry to 2-(1,3-diothiolan-2-ylidene)-cephem derivatives, which are new potent inhibitors of HSE.

Synthesis and beta-lactamase inhibitory activity of 2,2-bis(monosubstituted) methylpenicillin sulfones

A series of 2,2-bis(monosubstituted) methylpenicillin sulfones were prepared from 6,6-dibromopenicillanate by a double sulfoxide rearrangement. β-Lactamase inhibitory activity of 2,2-bis(chloromethyl)penicillanic acid sulfone was studied and its activity was compared with YTR-830

Synthesis and human leukocyte elastase inhibitory activity of novel 2-spiro(2′,2′-diphenylcyclopropane) cephalosporin sulfones

A new series of 2-spiro(2′,2′-diphenylcyclopropane) cephalosporin sulfones was synthesizes as potent human leukocyte elastase inhibitors.