Pauline Brendler Goettems Fiorin

Exposure to particulate matter modifies the pancreas extracellular/intracellular HSP70 ratio in high-fat diet treated mice: a marker of the diabetes development risk.

Background Evidences highlights exposure to fine particulate matter (PM2.5) as a risk factor for development of type 2 diabetes (T2D), especially in high-fat diet (HFD) fed mice. Under stressful conditions, cells respond by synthesizing a suite of intracellular stress response proteins, that plays a fundamental protective role in metabolic disorders, the 70 kDa family of heat shock proteins (iHSP70). However, while iHSP70 presents anti-inflammatory proprieties, their extracellular levels (eHSP72), presents pro-inflammatory roles. We propose to investigate the effects of HFD+PM2.5 association in the HSP70 status, and this relation to the risk of developing T2D.