Paulo Celso Pardi

Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.

Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways

This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.

EVALUATION OF BUCHE LEVELS IN PATIENTS WITH ALZHEIMER’S DISEASE

prevalence of IR was about 16%. Subjects above and below the cutoff values for IR (2.9 for HOMA-IR and 1.7 for HOMA2) did not show significant differences in terms of cerebral glucose metabolism, cognitive measures and demographic characteristics. No significant correlation was observed between peripheral IR calculated by either HOMA-IR or HOMA2 and rCMRGlc or ROI uptake of [18F]FDG. Conclusions: In this study of non-diabetic AD population with invasive measurement of cerebral glucose metabolic rate, we have demonstrated that peripheral insulin resistance does not correlate with cerebral glucose metabolism and thus it does not represent a good measure of central insulin resistance.

SALIVARY BIOMARKERS FOR THE DETECTION OF ALZHEIMER'S DISEASE

Al) were measured by flame or graphite furnace atomic absorption spectrometry. SOD activity was measured spectrophotometrically. Results:We have observed that, compared to controls, K and Fe levels were significantly increased in the CSF of AD individuals, while the concentration of Zn and Al were decreased. Further, we observed that total SOD activity was elevated CSF from AD individuals. Conclusions: We have demonstrated the existence of disturbances in the concentrations of K, Fe and Zn, total protein and SOD activity in AD subjects, compared to controls. Therefore ionic markers and their relationship with classical and oxidative stress biomarkers could provide new diagnostic tools for AD.