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Dive into the research topics where Paulo Sergio de Oliveira is active.

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Featured researches published by Paulo Sergio de Oliveira.


Brazilian Journal of Medical and Biological Research | 2010

A safety and feasibility study of cell therapy in dilated cardiomyopathy

Helena F Martino; Paulo Sergio de Oliveira; Fernando César Castro Souza; Patricia C. Costa; E. Assunção e Silva; Rita Villela; Miriam Gaze; Luiz Henrique Weitzel; Amanda Galvão de Oliveira; F.B. Muccillo; S.N.S. Arvelo; Ricardo Sá; T.C.F. Guimarães; Bernardo Rangel Tura; A.C. Campos de Carvalho

The aim of this study was to determine if bone marrow mononuclear cell (BMMC) transplantation is safe for moderate to severe idiopathic dilated cardiomyopathy (IDC). Clinical trials have shown that this procedure is safe and effective for ischemic patients, but little information is available regarding non-ischemic patients. Twenty-four patients with IDC, optimized therapy, age 46 ± 11.6 years, 17 males, NYHA classes II-IV, and left ventricular ejection fraction <35% were enrolled in the study. Clinical evaluation at baseline and 6 months after stem cell therapy to assess heart function included echocardiogram, magnetic resonance imaging, cardiopulmonary test, Minnesota Quality of Life Questionnaire, and NYHA classification. After cell transplantation 1 patient showed a transient increase in enzyme levels and 2 patients presented arrhythmias that were reversed within 72 h. Four patients died during follow-up, between 6 and 12 weeks after therapy. Clinical evaluation showed improvement in most patients as reflected by statistically significant decreases in Minnesota Quality of Life Questionnaire (63 ± 17.9 baseline vs 28.8 ± 16.75 at 6 months) and in class III-IV NYHA patients (18/24 baseline vs 2/20 at 6 months). Cardiopulmonary exercise tests demonstrated increased peak oxygen consumption (12.2 ± 2.4 at baseline vs 15.8 ± 7.1 mL·kg⁻¹·min⁻¹ at 6 months) and walked distance (377.2 ± 85.4 vs 444.1 ± 77.9 m at 6 months) in the 6-min walk test, which was not accompanied by increased left ventricular ejection fraction. Our findings indicate that BMMC therapy in IDC patients with severe ventricular dysfunction is feasible and that larger, randomized and placebo-controlled trials are warranted.


Arquivos Brasileiros De Cardiologia | 2005

Percutaneous Mitral Balloon Valvotomy. Long-term Outcome and Assessment of Risk Factors for Death and Major Events

Ivana Picone Borges; Edison Carvalho Sandoval Peixoto; Rodrigo Trajano Sandoval Peixoto; Paulo Sergio de Oliveira; Mario Salles Netto; Pierre Labrunie; Marta Labrunie; Ricardo Trajano Sandoval Peixoto; Ronaldo de Amorim Villela

OBJECTIVE To identify the factors that predict death and combined events, (death, new mitral balloon valvotomy, or mitral valve surgery) in long-term follow-up of patients undergoing percutaneous mitral balloon valvotomy. METHODS Follow-up was 49.0+/-31.0 (1 to 122) months. Techniques used were the single-balloon (84.4%), Inoue-balloon (13.8%), and double-balloon techniques (1.7%). RESULTS Included in the study were 289 patients 38.0+/-12.6 years of age (range, 13 to 83). Before the procedure, 244 patients had echocardiographic score < or = 8, and 45 patients had score > 8. Females comprised 85%, and 84% patients were in sinus rhythm. During follow-up, survival of the total group was 95.5%, that of the group with < or = 8 was 98.0%, finally that of the group with scores > 8 was 82.2% (P < 0.0001), whereas combined event-free survival was 83.4%, 86.1%, and 68.9%, respectively (P < 0.0001). In the multivariate analysis, the factors that predicted long-term death were a preprocedure echocardiographic score > 8 and the presence of severe valvular mitral regurgitation during the procedure. The events that predicted combined events were a previous history of mitral valvular commissurotomy and atrial fibrillation and the presence of severe mitral valvular regurgitation during the procedure, and postprocedure mitral valvular area < 1.5 m2 (failure). CONCLUSION Percutaneous mitral balloon valvotomy is an effective procedure, and over 2/3 of the patients were event-free at the end of follow-up. Survival in the group was high, even higher in the group with lower echocardiographic scores.


Arquivos Brasileiros De Cardiologia | 2006

Cell therapy in dilated cardiomyopathy

Helena F Martino; Paulo Sergio de Oliveira; Edmilson Assunção; Rita Villela; Miriam Gaze; Patricia C. Costa; Fernando César Castro Souza; Luiz Henrique Weitzel; Ana Paula R. Velloso; Amarino Carvalho de Oliveira Junior; Antonio Carlos Campos de Carvalho

A forty-one-year-old male with systolic heart failure, FC-III NYHA, clinical stage C due to dilated cardiomyopathy was submitted to an autologous transplant of the mononuclear fraction of bone marrow via coronary artery system through heart catheterism. Two months after the procedure, there was a decrease in plasma BNP and cardiac area reduction at the thorax X-ray and nuclear magnetic resonance. The echocardiogram showed decrease of the secondary regurgitation and mitral ring dilatation. There was a better performance at the ergospirometry, with increase of the maximum oxygen consumption and consequent reduction in drug therapy. The absence of adverse events characterized by clinical/hemodynamic instability, enzymatic alteration or electrocardiogram demonstrate the safety and feasibility of this procedure carried out and described with pioneering spirit in dilated cardiomyopathy.


Arquivos Brasileiros De Cardiologia | 1998

Balão único versus balão de Inoue na valvoplastia mitral percutânea por balão. Resultados imediatos e complicações

Edison Carvalho Sandoval Peixoto; Paulo Sergio de Oliveira; Mario Salles Netto; Ivana Picone Borges; Ronaldo de Amorim Villela; Pierre Labrunie; Cláudia Brum; Rodrigo Trajano Sandoval Peixoto; Marcello Augustus de Sena; Marta Labrunie; Ricardo Trajano Sandoval Peixoto; Daniela M. Burello

PURPOSE: To assess short-term results and complications of percutaneous mitral balloon valvuloplasty (PMBV) performed with Inoue balloon (IB) and single low profile balloon (SB). METHODS: We performed 390 PMBV procedures, 29 with IB and 337 with SB . There were no differences in age, sex, echocardiographic score distribution and echocardiographic mitral valve area (MVA). RESULTS: We performed 29 complete procedures with IB and 330 of 337 in SB group. Comparing IB and pre and pos-PMBV data we obtained: mean pulmonary artery pressure (MPAP) 36±15 and 39±14mmHg, p=0.2033, mean mitral gradient 17±6 and 20±7mmHg, p=0.0396 and MVA 0.9±0.2 and 0.9±0.2cm2, p=0.8043 and pos-PMBV: MPAP 25±8 and 28±10mmHg, p=0.2881, gradient 5±3 and 5±4mmHg, p=0.2778 and MVA 2.2±0.2 and 2.0±0.4cm2, p=0.0362. Mitral valve (MV) was competent in 26 patients in IB and in 280 in SB group and we had +/4 mitral regurgitation in 3 patients in IB and in 57 in SB group (p=0.3591) pre-PMBV respectively and pos-PMBV there was also no difference in MV competence (p=0.7439). CONCLUSION: Both techniques were effective. Hemodynamic data were also similar although MVA was greater in IB group after PMBV.


Arquivos Brasileiros De Cardiologia | 2001

Influence of the echocardiographic score and not of the previous surgical mitral commissurotomy on the outcome of percutaneous mitral balloon valvuloplasty

Edison Carvalho Sandoval Peixoto; Rodrigo Trajano Sandoval Peixoto; Ivana Picone Borges; Paulo Sergio de Oliveira; Marta Labrunie; Mario Salles Netto; Ronaldo de Amorim Villela; Pierre Labrunie; Guilherme A. Xavier de Brito; Ricardo Trajano Sandoval Peixoto

OBJECTIVE To evaluate prior mitral surgical commissurotomy and echocardiographic score influence on the outcomes and complications of percutaneous mitral balloon valvuloplasty. METHODS We performed 459 complete mitral valvuloplasty procedures. Four hundred thirteen were primary valvuloplasty and 46 were in patients who had undergone prior surgical commissurotomy. The prior commissurotomy group was older, had higher echo scores, and a tendency toward a higher percentage of atrial fibrillation. RESULTS When the groups were compared with each other, no differences were found in pre- and postprocedure mean pulmonary artery pressure, mean mitral gradient, mitral valve area, and mitral regurgitation. Because we found no significant differences, we subdivided the entire group based on echo scores, those with echo scores < or =8 and those with echo scores >8 the mitral valve area being higher in the < or =8 echo score group 2.06+/-0.42 versus 1.90+/-0.40 cm2 (p=0.0090) in the >8 echo score group. CONCLUSION Dividing the groups based on echo score revealed that the higher echo score group had smaller mitral valve areas postvalvuloplasty.


Arquivos Brasileiros De Cardiologia | 2006

[Balloon valvuloplasty outcome of a group previously submitted to mitral percutaneous or surgical valve repair versus first-time valvuloplasty patients. Evolution of the group previously submitted to valve repair procedures].

Edison Carvalho Sandoval Peixoto; Rodrigo Trajano Sandoval Peixoto; Ivana Picone Borges; Paulo Sergio de Oliveira; Mario Salles Netto; Ronaldo de Amorim Villela; Marta Labrunie; Pierre Labrunie; Ricardo Trajano Sandoval Peixoto

OBJECTIVE To evaluate 501 procedures of mitral balloon valvuloplasty and the differences among the group already submitted the prior surgical or balloon valvuloplasty, with 59 procedures and the group without previous intervention, with 442 procedures. METHODS It was used the single balloon in 403, Inoue balloon in 89 and a double balloon in six, with no difference between the 2 groups (p=0.6610). RESULTS The prior surgical or balloon valvuloplasty group was older, with higher echo score and higher atrial fibrillation rate and of its 59 patients, 48 had been submitted only to mitral surgical commissurotomy, 8 only to mitral balloon valvuloplasty and 3 to surgical commissurotomy and after submitted to balloon valvuloplasty because of restenosis. In prior surgical or balloon valvuloplasty and mitral balloon valvuloplasty without previous intervention groups pre valvuloplasty there were respectively: echo mitral valve area 0.99+/-0.21 and 0.94+/-0.21 cm2 (p=0.0802) and mitral valve area (Gorlin) 0.94+/-0.18 and 0.91+/-0.21 cm2 (p=0.2518) and post mitral valvuloplasty 1.95+/-0.44 and 2.05+/-0.42 cm2 (p=0.1059). CONCLUSIONS The hemodynamic and angiographic outcome of the prior surgical or balloon valvuloplasty group were similar to the group without previous intervention. The evolution was satisfactory in the prior valvuloplasty subgroup with long-term follow-up.


Revista Brasileira de Cardiologia Invasiva | 2005

Evolução a Longo Prazo da Valvoplastia Mitral Percutânea por Balão: Análise dos Fatores de Risco para Óbito e Eventos Maiores e da Evolução de Grupo de Risco

Edison Carvalho Sandoval Peixoto; Ivana Picone Borges; Rodrigo Trajano Sandoval Peixoto; Paulo Sergio de Oliveira; Mario Salles Netto; Pierre Labrunie; Marta Labrunie; Ricardo Trajano Sandoval Peixoto; Ronaldo de Amorim Villela


Arquivos Brasileiros De Cardiologia | 2001

Influência do escore ecográfico e näo da comissurotomia cirúrgica prévia no resultado da valvoplastia mitral percutânea por baläo

Edison Carvalho Sandoval Peixoto; Rodrigo Trajano Sandoval Peixoto; Ivana Picone Borges; Paulo Sergio de Oliveira; Marta Labrunie; Mario Salles Netto; Ronaldo de Amorim Villela; Pierre Labrunie; Guilherme A. Xavier de Brito; Ricardo Trajano Sandoval Peixoto


Arquivos Brasileiros De Cardiologia | 1993

Angioplastia renal transluminal percutânea no tratamento da hipertensäo renovascular

Angelo Leone Tedeschi; Edison Carvalho Sandoval Peixoto; Maurício Bastos de Freitas Rachid; Ronaldo de Amorim Villela; Mario Salles Netto; Pierre Labrunie; Paulo Sergio de Oliveira; Hélio R Figuera; Júlio César Machado Andréa; Ivana Picone Borges; Ellen Elizabeth M Barroso


Arquivos Brasileiros De Cardiologia | 1993

Percutaneous transluminal renal angioplasty in the treatment of renovascular hypertension

Angelo Leone Tedeschi; Edison Carvalho Sandoval Peixoto; Maurício Bastos de Freitas Rachid; Ronaldo de Amorim Villela; Mario Salles Netto; Pierre Labrunie; Paulo Sergio de Oliveira; Figuera Hr; Júlio César Machado Andréa; Ivana Picone Borges

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Mario Salles Netto

Federal Fluminense University

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Ivana Picone Borges

Federal Fluminense University

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José Geraldo de Castro Amino

Federal University of Rio de Janeiro

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Pierre Labrunie

Federal Fluminense University

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Marta Labrunie

Federal Fluminense University

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