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Dive into the research topics where Pavnesh Kumar is active.

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Featured researches published by Pavnesh Kumar.


Journal of the Egyptian National Cancer Institute | 2017

Burden of preventable cancers in India: Time to strike the cancer epidemic.

Ajeet Kumar Gandhi; Pavnesh Kumar; Menal Bhandari; Bharti Devnani; Goura Kishor Rath

India has a rapidly growing population inflicted with cancer diagnosis. From an estimated incidence of 1.45 million cases in 2016, the cancer incidence is expected to reach 1.75 million cases in 2020. With the limitation of facilities for cancer treatment, the only effective way to tackle the rising and humongous cancer burden is focusing on preventable cancer cases. Approximately, 70% of the Indian cancers (40% tobacco related, 20% infection related and 10% others) are caused by potentially modifiable and preventable risk factors. We review these factors with special emphasis on the Indian scenario. The results may help in designing preventive strategies for a wider application.


Journal of Global Oncology | 2018

Crizotinib-Induced Fulminant Hepatic Failure: A Rare Adverse Event

Narayan Adhikari; Pavnesh Kumar; Bhanu Prasad Venkatesulu; Rambha Pandey; K.P. Haresh; Subhash Gupta; Daya Nand Sharma; Goura K. Rath

Lung cancer is a leading cause of death with 1.8 million new cases and 1.6 million deaths worldwide in 2012.About 85%arenon–small-cell lung cancer (NSCLC) of which 4% to 7% are positive for anaplastic lymphoma kinase (ALK) gene rearrangement. Patients with ALK gene mutation define a distinct subgroup who are younger, who are light smokers or nonsmokers, and who have adenocarcinoma histology. The tyrosine kinase inhibitor crizotinib significantly improved clinical outcome in patients with ALK-positive advanced NSCLC when compared with conventional chemotherapy and is currently the first line of treatment for these patients. Crizotinib treatment is commonly associated with an increase in liver aminotransferases, which is reversible on dose reduction or interruption. We report a case of crizotinib-induced fulminant hepatic failure with hepatic encephalopathy.


Journal of the Egyptian National Cancer Institute | 2016

Invasive lobular carcinoma of the male breast: A rare histology of an uncommon disease

Rituraj Upadhyay; Pavnesh Kumar; D.N. Sharma; K.P. Haresh; Subhash Gupta; Pramod Kumar Julka; G.K. Rath; Himani Bhankar

Male breast carcinoma is a rare malignancy comprising less than 1% of all breast cancers. It is a serious disease with most patients presenting in advanced stages. Infiltrating ductal carcinoma is the most common histology while lobular carcinoma represents less than 1% of all these tumors. We report a case of locally advanced lobular carcinoma of breast in a 60 year old male.


Medical Physics | 2015

SU‐E‐T‐563: Multi‐Fraction Stereotactic Radiosurgery with Extend System of Gamma Knife: Treatment Verification Using Indigenously Designed Patient Simulating Multipurpose Phantom

Raj Kishor Bisht; Shashank Sharad Kale; N Gopishankar; G.K. Rath; Pramod Kumar Julka; Deepak Agarwal; Manmohanjit Singh; Ajay Garg; Pavnesh Kumar; Sanjay Thulkar; Bhawani Shankar Sharma

Purpose: Aim of the study is to evaluate mechanical and radiological accuracy of multi-fraction regimen and validate Gamma knife based fractionation using newly developed patient simulating multipurpose phantom. Methods: A patient simulating phantom was designed to verify fractionated treatments with extend system (ES) of Gamma Knife however it could be used to validate other radiotherapy procedures as well. The phantom has options to insert various density material plugs and mini CT/MR distortion phantoms to analyze the quality of stereotactic imaging. An additional thorax part designed to predict surface doses at various organ sites. The phantom was positioned using vacuum head cushion and patient control unit for imaging and treatment. The repositioning check tool (RCT) was used to predict phantom positioning under ES assembly. The phantom with special inserts for film in axial, coronal and sagittal plane were scanned with X-Ray CT and the acquired images were transferred to treatment planning system (LGP 10.1). The focal precession test was performed with 4mm collimator and an experimental plan of four 16mm collimator shots was prepared for treatment verification of multi-fraction regimen. The prescription dose of 5Gy per fraction was delivered in four fractions. Each fraction was analyzed using EBT3 films scanned with EPSON 10000XL Scanner. Results: The measurement of 38 RCT points showed an overall positional accuracy of 0.28mm. The mean deviation of 0.28% and 0.31 % were calculated as CT and MR image distortion respectively. The radiological focus accuracy test showed its deviation from mechanical center point of 0.22mm. The profile measurement showed close agreement between TPS planned and film measured dose. At tolerance criteria of 1%/1mm gamma index analysis showed a pass rate of > 95%. Conclusion: Our results show that the newly developed multipurpose patient simulating phantom is highly suitable for the verification of fractionated stereotactic radiosurgery using ES of Gamma knife. The study is a part of intramural research project of Research Section, All India Institute of Medical Sciences New Delhi India (A 247).


Medical Physics | 2012

SU‐E‐T‐587: Whole IMRT, Hybrid IMRT and 3D Conformal Plan a Dosimetric Comparison for Large Target

Sanjiv Sharma; D Manigandan; A.K. Gandhi; V Subramani; Dayanand Sharma; Pavnesh Kumar; Pramod Kumar Julka; G.K. Rath

PURPOSE To dosimetrically compare the whole-IMRT, hybrid-IMRT (combination of IMRT and 3D-CRT) and 3D-conformal radiotherapy (3D- CRT) plans for larger targets. METHODS Five previously treated patients of carcinoma cervix with para-aortic lymph-nodes (target length 33-34cm) were selected. PTV-P (PTV-Primary), PTV-PA (PTV-para-aortic) and organ at risks (OARs) were defined. Three plans were generated using Eclipse TPS for Varian CL2300C/D linear accelerator using 6MV photon beam. Three plans were: (i) Whole-IMRT: IMRT for both PTV-P and PTV-PA (ii) Hybrid-IMRT: IMRT for PTV-P and 3D-CRT for PTV-PA (iii) 3D-CRT: 3D-CRT for both PTV-P and PTV-PA. Prescription dose for PTV-P is 50.4Gy and PTV-PA is 45Gy in 28 fractions. Coverage index (CI=Target volume covered by prescription dose/Target volume), mean doses to bladder, rectum and bowel were used for plan comparison by using DVH. Integral dose (liter-Gray) to normal tissue (i.e., patient volume minus PTV-P and PTV-PA) and total monitor units (MUs) required to deliver a plan was also noted. RESULTS The CI for PTV-P is 0.98±0.20, 0.96±0.09, and 0.95±0.01 for Whole-IMRT, Hybrid-IMRT and 3D-CRT plan and for PTV- PA is 0.98±0.01, 0.98±0.01, and 0.97±0.20. Maximum doses to PTV-P are 5660.85±90.85cGy, 5640.35±70.35cGy and 5813.80±97.40cGy. Maximum doses to PTV-PA are 5000.60±109.10cGy, 5079.85±20.25cGy and 5092.25±19.75cGy. Mean doses to the bladder are 3810±225.80cGy, 3842.10±182.70cGy and 5204±98.25cGy for Whole-IMRT, Hybrid-IMRT and 3D-CRT plan, respectively. Mean doses to rectum are 3955.35±324.95cGy, 3971.15±354.15cGy and 4741.20±371.60cGy. Mean doses to bowel are 2623.35±320.85cGy, 2855.30±371.05cGy and 3011.7±433.80cGy. Average MUs required to deliver one fraction is 1285±87, 1585±186, 485±46 for Whole-IMRT, Hybrid-IMRT and 3D-CRT plans, respectively. Higher integral doses to normal tissue were observed for whole-IMRT (267.60±76 liter-Gy) followed by hybrid-IMRT (259.20±53 liter-Gy) and 3D-CRT (186.30±33 liter-Gy). CONCLUSIONS Whole-IMRT is useful for larger targets compared to hybrid-IMRT in terms of dose conformity, lesser MUs and reduced critical organ doses with little compromise on integral dose, where 3D-CRT sacrificed the OAR sparing.


International Journal of Radiation Oncology Biology Physics | 2015

Low-Dose-Rate Versus High-Dose-Rate Versus Pulsed-Dose-Rate Intracavitary Brachytherapy in Cervical Carcinoma: A Monoinstitutional Comparative Study

Dayanand Sharma; G.K. Rath; A.K. Gandhi; Pavnesh Kumar; K.P. Haresh; Siddhartha Datta Gupta; Rambha Pandey; Prashanth Giridhar


Archive | 2016

Gynecologic Oncology Pulsed-dose-rate vs. high-dose-rate intracavitary radiotherapy for locally advanced carcinoma of cervix: A prospective randomized study

Pavnesh Kumar; Daya Nand Sharma; Sunesh Kumar; Ajeet Kumar Gandhi; Goura Kishor Rath; Pramod Kumar Julka


Medical Physics | 2016

SU-F-T-593: Technical Treatment Accuracy in a Clinic of Fractionated Stereotactic Radiosurgery

Raj Kishor Bisht; Shashank Sharad Kale; Gopishankar Natanasabapathi; Manmohanjit Singh; Deepak Agarwal; G.K. Rath; Pramod Kumar Julka; Pavnesh Kumar; Sanjay Thulkar; Ajay Garg; B.S. Sharma


International Journal of Radiation Oncology Biology Physics | 2016

Role of Radiation Therapy and Its Impact on Survival of Male Breast Cancer Patients: Experience From a Tertiary Cancer Center

R. Upadhyay; Dayanand Sharma; A.K. Gandhi; K.P. Haresh; S. V. S. Deo; Ajay Gogia; Pavnesh Kumar; Subhash Gupta; Rambha Pandey


Brachytherapy | 2016

Pulsed-dose-rate vs. high-dose-rate intracavitary radiotherapy for locally advanced carcinoma of cervix: A prospective randomized study

Pavnesh Kumar; Daya Nand Sharma; Sunesh Kumar; Ajeet Kumar Gandhi; Goura Kishor Rath; Pramod Kumar Julka

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Pramod Kumar Julka

All India Institute of Medical Sciences

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G.K. Rath

All India Institute of Medical Sciences

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A.K. Gandhi

All India Institute of Medical Sciences

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K.P. Haresh

All India Institute of Medical Sciences

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Subhash Gupta

All India Institute of Medical Sciences

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Daya Nand Sharma

All India Institute of Medical Sciences

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Dayanand Sharma

All India Institute of Medical Sciences

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Rambha Pandey

All India Institute of Medical Sciences

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Goura Kishor Rath

All India Institute of Medical Sciences

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Sunesh Kumar

All India Institute of Medical Sciences

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