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Dive into the research topics where Pavol Ďurč is active.

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Featured researches published by Pavol Ďurč.


Talanta | 2018

Fast blood plasma separation device for point-of-care applications

Pavol Ďurč; František Foret; Petr Kubáň

In this work, a simple device for extremely fast separation of blood plasma from diluted whole blood was developed. The device accommodates an asymmetric polysulfone membrane/supporting membrane sandwich that allows collection of 10 µL blood plasma into a narrow glass capillary in less than 10 s. The composition of diluent solution was optimized in order to achieve maximum recoveries for selected metabolites of alcohol intoxication. 5% solution of [tris(hydroxymethyl)methylamino] propanesulfonic acid provided recoveries of formate, oxalate and glycolate close to 100% and only moderate erythrocyte lysis. Both charged and uncharged compounds from the whole blood samples can be analyzed in the separated blood plasma by capillary electrophoresis with contactless conductometric detection and spectrophotometry, respectively. The developed device might find wide application in on-site testing and point-of-care analysis, when only microliter volumes of whole blood are available.


Hungarian Journal of Industrial Chemistry | 2018

Study of Various Parameters that Influence the Content of Exhaled breath Condensate Used in the Diagnosis of Gastroesophageal Reflux Disease

Michal Greguš; Pavol Ďurč; Júlia Lačná; František Foret; Petr Kubáň

Abstract In this work, various parameters that influence the ionic content and pH of exhaled breath condensate in of the noninvasive diagnosis of gastroesophageal reflux disease were studied. Exhaled breath condensate samples were collected using a miniature and inexpensive sampling device. Capillary electrophoresis with contactless conductometric detection was used to monitor the ionic content of exhaled breath condensate. Background electrolyte composed of 20 mM of 2-(N-Morpholino)ethanesulfonic acid, 20 mM of L-Histidine, 2 mM of 18-Crown-6 and 30 M of cetyltrimethylammonium bromide facilitated the rapid separation of anions and cations, both in less than 2 minutes. The possibility of contamination of the exhaled breath condensate by saliva is discussed in detail. The day-to-day repeatability (n=5) of the ionic content and pH of the exhaled breath condensate was studied and was satisfactory, reflecting mainly the physiological variability


Hungarian Journal of Industrial Chemistry | 2018

Capillary Electrophoretic Analysis of Exhaled Breath Condensate in the Diagnosis of Gastroesophageal Reflux Disease

Petr Kubáň; Pavol Ďurč; Júlia Lačná; Michal Greguš; František Foret; Jiří Dolina; Štefan Konečný; Martina Doubková; Dagmar Kindlová; Eva Pokojová; Jana Skřičková

Abstract In this work, capillary electrophoresis with contactless conductometric detection (CCD) was used for the analysis of the ionic content of exhaled breath condensate (EBC) to differentiate between healthy individuals and patients with gastroesophageal reflux disease (GERD). The exhaled breath condensate was collected using a miniature sample collection device and the content analyzed using a separation electrolyte composed of 20 mM 2-(N-morpholino)ethanesulfonic acid, 20 mM L-histidine, 2 mM 18-Crown-6 and 30 M cetyltrimethylammonium bromide. The separation of anions took less than 2.5 minutes, while the cations were separated in less than 1.5 minutes. The most significantly elevated ions in the group of patients suffering from gastroesophageal reflux disease were chloride, nitrate, propionate and butyrate. Although the number of subjects was too small to draw definite conclusions with regard to the discriminatory power of these ions, the pilot data are promising for EBC as a useful non-invasive alternative for other methods used in the diagnosis of gastroesophageal reflux disease


Journal of Chromatography A | 2014

Separation of oxalate, formate and glycolate in human body fluid samples by capillary electrophoresis with contactless conductometric detection.

Petr Kubáň; Pavol Ďurč; Miroslava Bittová; František Foret


Analytical and Bioanalytical Chemistry | 2017

New approach for cystic fibrosis diagnosis based on chloride/potassium ratio analyzed in non-invasively obtained skin-wipe sweat samples by capillary electrophoresis with contactless conductometric detection

Pavol Ďurč; František Foret; Eva Pokojová; Lukáš Homola; Jana Skřičková; Vladimír Herout; Milan Dastych; Hana Vinohradská; Petr Kubáň


Journal of Clinical Gastroenterology | 2018

Evaluation of Important Analytical Parameters of the Peptest Immunoassay that Limit its Use in Diagnosing Gastroesophageal Reflux Disease

Jiří Dolina; Štefan Konečný; Pavol Ďurč; Júlia Lačná; Michal Greguš; František Foret; Jana Skřičková; Martina Doubková; Dagmar Kindlová; Eva Pokojová; Petr Kubáň


Archive | 2017

SYMPTOM PATTERNS AND TYPES OF GASTROESOPHAGEAL REFLUXES SIGNIFICANTLY DIFFER IN GROUPS OF EROSIVE ESOPHAGITIS AND NON-EROSIVE FORM OF GASTROESOPHAGEAL REFLUX DISEASE (GERD) PATIENTS

Štefan Konečný; Jiří Dolina; Martina Doubková; Jana Skřičková; Dagmar Kindlová; Eva Pokojová; Pavol Ďurč; Júlia Lačná; Michal Greguš; František Foret; Petr Kubáň


Archive | 2017

Vyšetření kondenzátu vydechovaného vzduchu metodou kapilární elektroforézy u vybraných plicních onemocnění s podezřením na gastroesofageální reflux

Dagmar Kindlová; Martina Doubková; Eva Pokojová; Jana Skřičková; Jiří Dolina; Štefan Konečný; Petr Kubáň; Pavol Ďurč; Júlia Lačná; Michal Greguš


Archive | 2017

Peptest v laboratoři a klinické praxi a jeho možnosti využití k diagnostice EER

Štefan Konečný; Jiří Dolina; Pavol Ďurč; Júlia Lačná; Michal Greguš; Martina Doubková; Jana Skřičková; Dagmar Kindlová; Eva Pokojová; František Foret; Petr Kubáň


European Respiratory Journal | 2017

Assessment of exhaled breath condensate for non-invasive diagnosis of gastroesophageal reflux disease

Martina Doubková; Jana Skřičková; Jiří Dolina; Dagmar Kindlová; Eva Pokojová; Pavol Ďurč; Júlia Lačná; Michal Greguš; Štefan Konečný; František Foret; Petr Kubáň

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Petr Kubáň

Central European Institute of Technology

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